Zhejiang Chinese Medical University

Association of the dietary carbohydrate-to-fiber ratio with prevalent rheumatoid arthritis in NHANES 2009–2018

This study examines the cross-sectional association between the carbohydrate-to-fiber ratio (CFR), an indicator of carbohydrate quality, and prevalent rheumatoid arthritis (RA) in the National Health and Nutrition Examination Survey (NHANES). The exposure was overall CFR, calcula...

Imaging Manifestations and Clinical Analysis of 12 Cases of Anorectal Malignant Melanoma

AIM: To investigate the computed tomography (CT) and magnetic resonance imaging (MRI) features and clinical characteristics of primary anorectal malignant melanoma (ARMM).METHODS: This retrospective analysis was conducted on the clinical, imaging and pathological data of 12 patie...

Repeat pulmonary resection for multiple primary lung cancer: perioperative safety and long-term oncological outcomes

With widespread low-dose CT screening, multiple primary lung cancer (MPLC) diagnoses have markedly increased. Surgical resection remains the preferred treatment; however, repeat pulmonary resection is technically demanding due to pleural adhesions and altered anatomy from prior s...

Sphingomyelin (30:1; O2) as a novel lipid biomarker associated with the diagnosis of intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is a primary hepatic malignancy with an incidence second only to hepatocellular carcinoma (HCC). Preoperative differentiation between ICC and HCC remains challenging in certain cases. This study aimed to identify potential diagnostic lipid bi...

Natural Polysaccharides in Health and Targeting TGF-β/Smad Signaling Therapy in Chronic Diseases

Abstract Chronic diseases including cardiovascular disorders, cancers, diabetes and organ fibrosis are major global causes of mortality. The transforming growth factor-β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) cascade governs key physiological events spanning...

Analytical performance and clinical classification value of a novel sandwich immunoassay for total testosterone measurement in low-concentration and hemodialysis populations

Abstract Objectives To evaluate the analytical performance and clinical classification value of a novel sandwich testosterone immunoassay, particularly for biochemical testosterone elevation in women and deficiency in male hemodialysis patients, using LC–MS/MS as the reference me...

SpyGlass-assisted diagnosis of biliary tract invasion by diffuse large B-cell lymphoma: a case report

Abstract Background Diffuse large B-cell lymphoma (DLBCL) of the common bile duct (CBD) is exceedingly rare and mimics cholangiocarcinoma or choledocholithiasis, delaying diagnosis. Endoscopic Retrograde Cholangiopancreatography (ERCP) brush cytology offers limited sensitivity fo...

BBR-RHE Co-Loaded Nanoemulsion Potentiates Anti-PD-L1 Efficacy via Lipid Metabolic Reprogramming in Triple-Negative Breast Cancer

Abstract Triple-negative breast cancer (TNBC) therapy is limited by the poor efficacy of anti-programmed death-ligand 1 (aPD-L1) monotherapy, with dysregulated lipid metabolism in the tumor microenvironment (TME) driving immunosuppression. Herein, a nanoemulsion co-loaded with be...

Engineering of Azo-Crosslinked Alginate Hydrogels for Targeted Oral Local Biologic Delivery

Abstract Oral delivery of therapeutic biologics is constrained by gastrointestinal degradation and premature leakage from physical hydrogels. Here, microfluidic-engineered azo-crosslinked alginate (SA-Azo) microspheres were fabricated via template-assisted covalent substitution,...

Superior diagnostic efficacy and cost advantage of FibroTouch over CHI3L1 for liver fibrosis in Chinese patients with chronic liver disease

Background Non-invasive assessment of liver fibrosis is essential for managing chronic liver disease (CLD). Serum chitinase-3-like protein 1 (CHI3L1) has been recommended in recent guidelines, while FibroTouch is a domestically produced device for liver stiffness measurement (LSM...

Diagnosis of ankylosing spondylitis

Background: The pathogenesis and pathological progression of ankylosing spondylitis (AS) remain unclear. Owing to the absence of a gold standard for diagnosing AS, diagnostic delays are frequently encountered in clinical practice, exacerbating the disease burden. In the past 16 y...

Identification and Characterization of EmNag, a Novel β-1,2-N-Acetylglucosaminidase from Elizabethkingia meningoseptica

Abstract N-Acetylglucosamine exists in various glycoforms and linkage patterns within organisms, playing a crucial role in numerous vital biological processes. The signal of β-1,2-N-acetylglucosamine is a key component within complex biantennary N-glycans on the cell surface, lea...

Ubiquitination-Dependent Cyclin Regulation in Gastric Cancer and Emerging Targeted Therapies with Chinese Herbal Bioactive Compounds

Gastric cancer (GC) remains one of the most prevalent malignancies worldwide, with a high mortality rate primarily attributable to late-stage diagnosis and limited therapeutic options. Aberrant cell proliferation arising from cell cycle dysregulation is a hallmark of GC pathogene...

Nanozyme‐Assisted Engineered Oncolytic Adenovirus for Improving Intratumoral Immune Deficiency and Enhancing Cancer Immunotherapy

ABSTRACT Oncolytic adenovirus (OA) exhibit tumor‐selective tropism, inducing direct oncolysis while simultaneously potentiating host immune responses against malignancies. However, the poor delivery efficiency of the virus targeting tumors and its limited immune activation capaci...

First Report of Soft Rot on Corydalis yanhusuo Caused by Pectobacterium versatile in China

Corydalis yanhusuo (Yanhusuo) is a traditional Chinese medicinal herb. From March to May 2023 and 2024, a previously unrecorded soft rot was observed in Panan County, Zhejiang Province, China (N29°12', E120°32'), with disease incidence of 10–50% (up to 80% in some fields). Initia...

Ultrasound-activated Cu2−XSe/TiO2 heterostructured nanosonosensitizer enables coordinated induction of ferroptosis and cuproptosis for tumor immunotherapy

Triple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by the absence of actionable molecular targets, high metastatic propensity, and limited responsiveness to current immunotherapies. Although immune checkpoint inhibitors show promise, their clinical...

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Abstract The global public health burden of aortic valve disease (AVD) is growing due to its high mortality rate and lack of suitable pharmaceutical therapies in clinical practice, a challenge that is largely attributable to our poor understanding of its complicated underlying me...

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

ABSTRACT Extracellular pore domains of ion channels are emerging as dynamic regulatory surfaces, but whether they can be rationally targeted to achieve selective channel modulation remains unclear. Here, using an optimized hotspot‐centric design strategy, we developed Depiv2, a s...

The deubiquitinating enzyme USP42 promotes lung adenocarcinoma progression through PTGS2

The ubiquitin-specific peptidase 42 (USP42) is a cysteine-dependent deubiquitinase with pro-tumorigenic roles in several cancers. In lung adenocarcinoma (LUAD), elevated USP42 expression correlates with advanced stage and poor survival, mirroring the prognostic impact of prostagl...

An Insights Research into Motivating China 70 Cities Comparative Growth Amount on Scientist Evaluation Sustainably

The electric vehicle would represent the latest technique where the key one batteries group is too big and heavy that may influence the car rotary-inertia make the car bigger force to drive. Another one will be the battery anti-coldness capacity in north area &winter knowing how...