Zhejiang Chinese Medical University

Two‐ to six‐year outcomes of tunnel technique with connective tissue graft in multiple mandibular anterior recessions

Abstract Background The purpose of this study is to report the 2–6 year outcomes of the tunnel technique with a connective tissue graft (TUN+CTG) in treating multiple Cairo recession type 1 and 2 recessions over a 2–6 year follow‐up, and the influence of CTG exposure on treatment...

Is Body Roundness Index a Predictor of Cancer Incidence and Mortality? A Prospective Cohort Study

ABSTRACT Body Roundness Index (BRI) is a novel measure of visceral and total body fat. Its association with multiple cancers and predictive value relative to Body Mass Index (BMI) remain unclear. The associations between BRI and the incidence and mortality (specific, overall and...

Mendelian randomization and drug repurposing analysis identifies APOE as a potential therapeutic target for low back pain

Abstract Background: Low back pain (LBP) is a prevalent chronic pain syndrome primarily driven by spinal degeneration, causing persistent disability and reduced quality of life. Despite available interventions, identifying novel therapeutic targets remains imperative for modifyin...

First-line sugemalimab plus chemotherapy for metastatic non-small-cell lung cancer: an updated cost-effectiveness analysis based on 4-year survival data

OBJECTIVE: Incorporating the 4‑year long‑term survival outcomes from the GEMSTONE‑302 trial, this study aimed to evaluate the cost‑effectiveness of sugemalimab plus chemotherapy versus chemotherapy alone as first‑line treatment for metastatic non‑small‑cell lung cancer (NSCLC) fr...

Safety of TNF-α inhibitors, IL-17 inhibitors, and JAK inhibitors in the treatment of axial spondyloarthritis: a protocol for a multi-method study integrating FAERS data mining, dose–response network meta-analysis, and drug-target Mendelian randomization

Biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs), including tumor necrosis factor-α inhibitors (TNFi), interleukin-17 inhibitors (IL-17i), and Janus kinase inhibitors (JAKi), are standard treatments for axial spondyloarthritis (axSpA). However...

Global Trends and Research Hotspots in Natural Products for Hyperuricemia: A Bibliometric Analysis (2004–2026)

Hyperuricemia (HUA) is a key pathological basis for gout and uric acid (UA) nephropathy, and its increasing global prevalence presents a substantial public health challenge. Natural products (NPs) have emerged as a research hotspot due to their potential to reduce UA and favourab...

Ultrasmall PolymericMicelles Enable Noninvasive TransdermalRosiglitazone Delivery via Lipid Fluidization and Transcytosis

Abstract Noninvasive transdermal drug delivery (TDD) offers sustained therapeutic release but is hindered by the stratum corneum (SC) barrier. Herein, we report ultrasmall polymeric micelles (PMs) embedded in poly(vinyl alcohol) hydrogels for the passive TDD of rosiglitazone (RGT...

Interpretable multi-label prediction of institution-defined IgA nephropathy clinical patterns using routine cross-sectional clinical and laboratory data

IgA nephropathy (IgAN) clinical heterogeneity leads to inconsistent documentation of multiple, institution-specific pattern labels, creating an imbalanced multi-label phenotyping challenge. We developed an interpretable hybrid model, the Bidirectional Long Short-Term Memory-Convo...

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Postoperative pain impairs patients' quality of life. Mechanisms underlying postoperative pain remain incompletely understood. We investigated postoperative pain in a mouse model of skin plus deep tissue incision (INC). We found Cxcl5 was among the top upregulated genes in incisi...

Construction and validation of a prediction system for postherpetic neuralgia: based on meta-analysis

Postherpetic neuralgia (PHN) is a chronic and intractable pain disorder. Existing PHN prediction systems have limited clinical applicability. A systematic search of the literature was conducted in PubMed, Web of Science, Embase and the Cochrane Library between 1950 and 2025, fina...

Consistency of urethroscopy vs. high-frequency ultrasound in diagnosing male urethral condyloma acuminatum

Abstract Objectives Urethral condyloma acuminatum(CA) is characterized by hidden growth, high treatment difficulty, high recurrence rate, and significant harm. Urethroscopy is a traditional method for examining male urethral CA. As a safe, non-invasive, highly reproducible, and c...

Exploring the molecular pathways of Noncoding RNAs in ovarian cancer: insights into treatment resistance

Ovarian cancer ranks as the third most common gynecological malignancy, yet it has the highest mortality and recurrence rates among all gynecologic cancers. Chemotherapy combined with immunomodulators and targeted agents, including PTX, ADR, PARPi, and platinum-based chemotherape...

Ultrafiltered Mulberry (Morus alba L.) Leaf Albumin-Type Protein Attenuates High-Fat Diet-Induced Obesity in Mice by Remodeling Gut Microbiota and Metabolic Homeostasis

Obesity is a chronic metabolic disorder closely associated with dyslipidemia, insulin resistance, low-grade inflammation, and gut microbiota dysbiosis. Mulberry leaves are rich in bioactive proteins, but whether mulberry leaf albumin-type protein can improve diet-induced obesity...

“Jun-Chen-Zuo-Shi” - the Chinese medical perspective on clinical oncology nutritional therapy

Abstract Cancer-associated malnutrition and cachexia are common, clinically consequential syndromes that compromise treatment tolerance, increase postoperative and therapy-related complications, diminish quality of life, and shorten survival. Nutritional therapy is therefore incr...

Letter Regarding the “Wrist-Ankle Acupuncture on Postoperative Nausea and Vomiting Prophylaxis in High-Risk Female Patients: A Pragmatic, Randomized, Single-Blind, Sham-Controlled Trial”

To the Editor,We read with great interest the article by Yu et al. [1] evaluating the efficacy of wrist-ankle acupuncture (WAA) for preventing postoperative nausea and vomiting (PONV) in high-risk ...

Patient Characteristics and Engagement in CGM‐Supported Virtual Weight Management

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

Identification of cognitive subtypes and risk networks in Chinese older adults: based on latent profile analysis and explainable machine learning

Traditional cognitive screening often relies on total scores, which can easily mask asynchronous impairment patterns across different cognitive domains. In particular, calculation ability, a sensitive indicator of executive function, is frequently misattributed to normal aging an...

Platelet count combined with Child-Turcotte-Pugh score for predicting rebleeding in cirrhotic patients with esophagogastric variceal bleeding

To investigate the predictive value of platelet count (PLT) combined with the Child-Turcotte-Pugh (CTP) score for rebleeding in cirrhotic patients with esophagogastric variceal bleeding (EGVB). This single-center retrospective study included 332 eligible patients selected from 37...

ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2

The COVID-19 pandemic and its protracted consequences underscore the urgent need for more effective antiviral strategies. Current antiviral strategies face a persistent challenge achieving sufficient viral suppression while minimizing off-target toxicity, particularly against suc...

CD34+ cells contribute to cardiac remodeling during disease development.

cell enrichment toward lineage-specific therapeutic strategies.