Warsaw University of Technology

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Acute myeloid leukaemia (AML) is a therapeutically challenging malignancy driven by the self-renewal, quiescence, and therapy resistance of leukaemic stem cells (LSCs). CDK8, a kinase component of the Mediator complex, regulates oncogenic transcription, and the selective CDK8/CDK...

Linear and nonlinear modelling for capacity assessment of Saxon Street overbridge BFO/1B

This paper presents a summary of the assessment of Saxon Street overbridge (BFO/1B), located in Milton Keynes, as conducted by AtkinsRéalis to determine the bridge’s remaining live load capacity. Previous assessments indicated that the bridge was unable to support rail live loadi...