Vita-Salute San Raffaele University

Salivary Dim‐Light Melatonin Onset is Associated with Functional Decline, Respiratory Symptom Emergence, and Survival in Early Amyotrophic Lateral Sclerosis

OBJECTIVE: Sleep-wake and circadian disturbances are increasingly recognized in people living with amyotrophic lateral sclerosis (plwALS), but endogenous circadian phase timing and its prognostic significance in early disease remain unclear. We assessed whether salivary dim-light...

Early Introduction and Prolonged Full‐Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort

Background Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management. Methods We retrospec...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Impaired Flow and Physiology in Coronaries With Anomalous Origin From the Opposite Sinus of Valsalva

BACKGROUND: Anomalous Aortic Origin of a Coronary Artery (AAOCA) high-risk anatomical features (intramural segment, acute take-off angle, slit-like ostium) cause coronary stenosis leading to myocardial infarction. How these features alter coronary physiology remains unclear. AIMS...

Impaired Neural Pattern Separation During Implicit Emotion Regulation in PTSD: An MVPA fMRI Study

Abstract Implicit emotion regulation (IER) operates automatically and supports adaptive social–affective functioning. Although PTSD involves marked IER disturbances, the large-scale functional connectivity architecture supporting implicit emotional processing remains unclear. The...

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Training the Next Generation of Future Surgical Residents: A Scoping Review and Proposal for an Undergraduate Curriculum From the Italian Polispecialistic Society of Young Surgeons

AIM: The transition from medical school to surgical residency is marked by a persistent gap between theoretical instruction and clinical readiness. In Italy, variability in training programs across centers creates persistent gaps in residents’ medical education. Scientific societ...

Preliminary evidence of long‐term safety and effectiveness of anti‐ CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort o...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

The GRAVITY score (grading severity and frequency in hemorrhoidal disease): development and initial evaluation of a composite patient-reported outcome measure

Abstract Background Hemorrhoidal disease (HD) is characterized by heterogeneous symptoms including bleeding, prolapse, pain, itching, and soiling. Currently available patient-reported outcome measures evaluate complementary but distinct symptom dimensions. The aim of this study w...

Everything you always wanted to know about sleep, but you were afraid to ask: expert concise guide and recommendations on assessing sleep-wake disturbances within a psychiatric context in contemporary times

OBJECTIVE: While disrupted sleep has long been linked to mental disorders there has been a notable decrease in interest and sleep-wake disorders have received low priority in psychiatric care. The aim of the paper was to present a concise guide for evaluating common sleep-wake di...

Adeno‐associated virus ‐mediated restoration of Na V 1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of Na V 1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures,...

Performance evaluation of a preclinical SPECT system and optimization of imaging protocols for 177Lu-labelled radiopharmaceuticals

This study investigates the performance of the γ-CUBE preclinical SPECT scanner to optimize acquisition and reconstruction protocols for theranostic preclinical studies, and to determine the minimum administered activity of a novel 177 Lu-labelled peptide in a mouse cancer model...

Growth factor polygenic disposition shapes associations of childhood adversity with gray matter and clinical profiles in depression: A two‐cohort imaging‐genetics study

Aim Adverse childhood experiences (ACE) are associated with greater symptom severity and treatment resistance in major depressive disorder (MDD), but their effects vary markedly across individuals. Growth factor polygenic profiles may contribute to this differential susceptibilit...

Translation, Cultural Adaptation and Psychometric Validation of the Italian Version of the Dignity in Care Scale for Nurses

AIM: To translate, culturally adapt and validate the Dignity in Care Scale for Nurses (DISC-N) into the Italian language. DESIGN: A national multicentre cross-sectional study. METHODS: Translation and cultural adaptation followed recognised guidelines for health measurement instr...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Serum NfL predicts visual recovery and neuronal loss after optic neuritis

Optic neuritis, a common manifestation of multiple sclerosis, involves acute axonal injury and variable visual recovery. We evaluated whether serum neurofilament light chain predicts visual and structural outcomes after first-episode optic neuritis. Fifty-one patients (mean age =...

Comparative Effectiveness of Tocilizumab and Tumor Necrosis Factor Inhibitors in Takayasu Arteritis: Age‐Related Differences in Treatment Response

OBJECTIVE: Comparative, prospective data on biologics for Takayasu arteritis (TAK) are limited. We compared tumor necrosis factor inhibitors (TNFi) and tocilizumab (TCZ) in a combined cohort, assessed demographic and cytokine influences, and evaluated longitudinal outcomes. METHO...

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...

Spatial extension of parafoveal processing predicts reading speed gain during reading acceleration

Fast and efficient reading involves not only processing the currently fixated word but also simultaneous processing of the upcoming text. Although the role of extrafoveal processing in natural reading has been extensively documented, its contribution to reading acceleration benef...