Virginia Commonwealth University

Beta-Lactam Dose Optimization Using Therapeutic Drug Monitoring in Pediatric Patients

OBJECTIVE: Beta-lactam therapeutic drug monitoring (BL-TDM) is underused in pediatric patients where drug exposure is highly variable. This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of BLs in pediatrics. PATIENTS AND METHODS: A retrospective ob...

Natural Language Processing to Improve Vertebral Fracture Identification in Older Adults Receiving Osteoporosis Therapy

INTRODUCTION: Vertebral fracture identification using administrative codes is challenging because diagnoses often occur outside hospital and orthopedic care settings. Outpatient diagnoses improve capture but increase misclassification. Accurate methods are important for populatio...

Group trends in posttraumatic stress disorder and suicidal ideation over the 10 years after traumatic brain injury among veterans/service members: A VA model systems study

Abstract Objective To identify group‐based patterns in suicidal ideation (SI) and posttraumatic stress disorder (PTSD) symptoms over the first 10 years after traumatic brain injury (TBI) among Veterans and Service Members (V/SMs). Setting V/SMs enrolled in the Department of Veter...

Curvature-Enhanced and Chirality-Modulated Anomalous Thermal Transport in Pentagonal Covalent Organic Framework Nanotubes

Abstract The emergence of covalent organic framework (COF) nanotubes extends tubular materials from rigid atomic networks to flexible molecular frameworks, yet their thermal transport properties remain unexplored. Here, based on an experimentally synthesized two-dimensional penta...

Performance of the iBox Prognostication System in African American Kidney Transplant Recipients

Background: The iBox is a validated prognostication system that predicts long-term death-censored graft loss in kidney transplant recipients, but its performance in the specific population of African American recipients has not been fully studied. Methods: We conducted a multicen...

Complete genome sequences of 38 Streptococcus sanguinis human-associated isolates

ABSTRACT We report the complete genome sequences of 38 Streptococcus sanguinis genomes, isolated from human oral and endocarditis-associated samples. These genomes are each comprised of a single chromosome that ranges from approximately 2.29 to 2.48 Mb in length, with an average...

Neighborhood Contemporary Redlining and Racial Mortgage Lending Bias and Cardiovascular Outcomes in Women With Breast Cancer

BACKGROUND: Studies have demonstrated neighborhood structural inequities are associated with cardiovascular outcomes among breast cancer survivors. We investigated the associations between bias in mortgage lending practices (contemporary redlining and racial lending bias) and car...

Evaluation of Inter-Method Reliability Between Palarum PUP Smart Socks® and the Opal v1 Mobility Lab System Among Ambulatory Adults

Early mobilization (EM) can mitigate hospital-acquired deconditioning by preserving prehospital functional status. EM measurement is challenging due to concerns such as accuracy and patient comfort. Palarum PUP® Smart Socks were designed for the hospital setting to track step cou...

Long-term comparative trajectories of health, behavioral, and economic outcomes: From pre-diagnosis to survivorship

Purpose Although cancer survivorship involves interconnected changes in health, health behaviors, and economic well-being, few studies have comprehensively examined how these outcomes evolve before and after a cancer diagnosis within the same population over time. Using populatio...

Additive Manufacturing of Redox-Active Covalent Organic Frameworks for High-Areal-Capacity Lithium-Sulfur Batteries

Covalent organic frameworks (COFs) have emerged as promising sulfur hosts for lithium-sulfur batteries; however, most studies rely on conventional two-dimensional cast cathodes, which restrict practical sulfur loading levels and areal capacity. Here, we report a 3D direct ink wri...

Efficacy of student developed and led high value care education in preclinical medical students

The Institute of Medicine estimates that, on average, about one third of all healthcare waste is attributed to unnecessary services. High value care (HVC) is a proposed solution to this problem but is currently underrepresented in preclinical undergraduate medical education (UME)...

Unmet Pet Caregiving Needs are Associated with Depression and Anxiety Symptoms Among People Living with HIV

People living with HIV (PLWH) experience disproportionately high rates of depression and anxiety. Human–animal interactions (HAI), particularly through pet ownership, may provide emotional support and companionship; however, the human–animal bond can be threatened by structural a...

Menopausal Hormone Therapy and Cardiovascular Risk: Current Evidence and Treatment Recommendations

In 2025, the US Food and Drug Administration (FDA) removed its prior class-wide boxed warnings for menopausal hormone therapy (MHT), paving the way for increased clinical use. Menopause accelerates cardiovascular risk independently of chronological aging, manifesting as a 7.5% in...

Compartment-specific collagen architecture in Crohn’s disease biopsies using SHG/TPE microscopy: a pilot feasibility study

Intestinal fibrosis in Crohn’s disease (CD) is a key determinant of stricture formation, but collagen architecture is difficult to assess on routine mucosal biopsies because of limited tissue depth and the lack of quantitative tissue-based fibrosis measures. We evaluated the feas...

Proximity Is Not Access: Geographic Distance and Chemotherapy Receipt for Colon Cancer Requiring Surgery

Background Access to health care facilities presents an obstacle to receiving appropriate cancer treatment. This retrospective cohort study analyzes how access to care by geographic distance and patient demographics affect receipt of chemotherapy in colon cancer patients requirin...

Transnasal Administration of Surfactant Aerosol to the Lungs of Infants Using Direct Interfaces – Lessons Learned from Computational Fluid Dynamics

PURPOSE: Direct-to-infant (D2I) transnasal aerosol surfactant therapy (AST) offers a promising non-invasive alternative for treating neonatal respiratory distress syndrome (RDS). However, achieving high lung delivery efficiency with dry powder inhalers (DPIs) requires careful opt...

Human Muscle-Derived Cells Injected into Acute and Chronic Muscle Injuries Engraft and Support Regenerative Markers

Urinary incontinence (UI), the involuntary leakage of urine, is a common condition that imposes significant physical, emotional, and financial burdens. Injury to the external urethral sphincter (EUS) contributes to myogenic UI by damaging the skeletal muscle responsible for urina...

Ethics at the Center: Interpreting Title IX’s Shifts Through the Lens of Professional Duty in Oral Health Education and Practice

Background Title IX is a foundational civil rights law affecting educational environments, including dental education. Ongoing regulatory changes have created uncertainty for institutions, raising questions about whether compliance alone is sufficient to fulfill dentistry’s profe...

Peroneal Muscle Size and Quality Changes after Impairment-Based Rehabilitation in Patients with Chronic Ankle Instability

Background Peroneal muscles are the primary stabilizers against ankle inversion movements associated with lateral ankle sprains. Individuals with chronic ankle instability (CAI) demonstrate peroneal muscle deficits including decreased strength, slower nerve conduction velocity, a...

Factors Influencing The First and Second Peak of COVID-19 Global Cases: A Survival Analysis

Abstract Objectives The number of reported cases continues to increase everyday, since the first case of COVID-19 was detected in Wuhan, China in December 2019. Using the global COVID-19 data of 188 countries extracted from the Our World in Data between January 22, 2020–January 1...