Vanderbilt University Medical Center

Student Perceptions on Educational Handovers from Medical School to Residency

Abstract To improve the transition to residency, the Coalition for Physician Accountability recently recommended a post-Match, learner-driven educational handover. Few studies have analyzed students’ perspectives on the content of handovers, especially the inclusion of personal v...

From HLA Association to Tissue Injury: Lessons from Drug Hypersensitivity and Multiple Sclerosis

HLA associations are among the strongest genetic signals in immune-mediated disease, yet they rarely explain incomplete penetrance, tissue localization, or opposing effects of different alleles. We use T cell-mediated drug hypersensitivity and multiple sclerosis as complementary...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...

Fusarium falciforme keratitis in a corneal transplant recipient treated successfully with fosmanogepix and intracameral amphotericin B

ABSTRACT Background Ocular fungal infections are a major cause of vision loss worldwide. Fusarium spp., a leading cause of fungal keratitis, is often difficult to treat. There are no current standardized treatment guidelines for fungal keratitis. We present a case of Fusarium spp...

Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics

Abstract Allograft rejection following solid-organ transplantation is a major cause of graft dysfunction and mortality. Current diagnostic approaches rely on histology, which exhibits wide diagnostic variability and lacks clinically relevant molecular phenotyping. Here we leverag...

Use of machine learning to enhance detection of transient astronomical phenomena in historical observatory images

Transient, star-like point sources that appear and vanish over short timescales are described in astronomical images prior to launch of Sputnik. We have reported that transient numbers diminish significantly in Earth’s shadow (shadow deficit) and are more likely within (+/-) one...

Burden of Disease in Pediatric Tumor-Induced Osteomalacia: A Literature Review

Tumor-induced osteomalacia (TIO) is an ultra-rare, paraneoplastic syndrome caused by tumors secreting fibroblast growth factor 23 (FGF23). In children, TIO may be mistaken for more common causes of rickets and osteomalacia, including monogenic forms, leading to long diagnostic de...

Identification of Siderophores With Unexpected Antibacterial Properties From Actinoplanes teichomyceticus

Actinoplanes teichomyceticus is a well‐established producer of bioactive secondary metabolites, including the glycopeptide antibiotic teicoplanin. Although its antibiotic biosynthetic capacity has been extensively investigated, its siderophore diversity and any additional biologi...

ATR is a critical dependency gene for uveal melanoma

GNAQ , GNA11 , CYSLTR2 , and PLCB4 are well-characterized oncogenic drivers of uveal melanoma (UM). The oncogenic stress induced by these mutations creates a reliance on specific dependency genes that support tumor cell proliferation and survival. However, the genes that broadly...

Prioritizing clinical utility to use allostatic load as a biomarker of the consequences of stress

Allostatic load measures the physiological consequences of stress and is associated with disease outcomes. Clinical use of allostatic load is limited, in part, because its calculation requires biomarkers not routinely measured in clinical care. Presently, we evaluated association...

Intraprocedural cardiac computed tomography-fluoroscopy image fusion guided structural heart intervention: a proof of concept experience during transcatheter aortic valve implantation

Intraoperative image guidance using cardiac CT with fluoroscopy image fusion has been shown to facilitate structural heart interventions. However, there has been limited experience on CT image fusion with fluoroscopy using aortic root calcifications from intraoperative 3D cone-be...

Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults

Importance For acutely ill adults who are hospitalized with hypoxemia, supplemental oxygen is titrated to maintain normoxemia. In current practice, clinicians intermittently titrate oxygen, potentially exposing patients to hypoxemia and hyperoxemia between assessments. Autonomous...