University of Turku

Population pharmacokinetics of methylprednisolone in neonates and paediatric patients undergoing cardiac surgery with cardiopulmonary bypass

<title>Abstract</title> <bold>Purpose</bold> Methylprednisolone is commonly used during paediatric cardiac surgery with cardiopulmonary bypass to attenuate the systemic inflammatory response. However, developmental differences in drug disposition and procedural factors such as ci...

Joint-RPCA: domain-aware multi-omics integration for systems microbiology

Integrating multi-omics data is essential for microbiome research, as microbial communities are shaped by and respond to interdependent processes, including taxonomic composition, metabolite production and utilization, and gene expression. However, accurately capturing ecosystem-...

Modeling the Subglacial Sediment System of the Finnish Lake District Ice Lobe During Deglaciation

Abstract. The systematic connection of glacial conditions in ice models with subglacial geomorphological observations has been limited by an inability to model subglacial sediment processes. The Finnish Lake District Ice Lobe (FLDIL) presents an opportunity to apply new model app...

Georges Ifrah, Lucien Gerschel, and four as the limit of small number systems

In his popular book Universal History of Number Georges Ifrah gives several examples of small number systems. Ifrah uses them as evidence of the idea that small number systems have a limit of four and count: one, two, two-one, two-two, many. The sources and origins of Ifrah’s hyp...

Depolarization ratio of smoke and volcanic ash aerosol particles at 1565 nm using a HALO Doppler lidar

Abstract. Particle linear depolarization ratio is a widely used parameter in lidar research to distinguish different aerosol types and the thermodynamic phase of water. It is most frequently measured at ultraviolet and visible wavelengths (355 and 532 nm), yet multi-wavelength ob...

Longitudinal associations between sleepiness and sleep disturbances across pregnancy

OBJECTIVE: Although sleep disturbances increase during pregnancy, sleepiness does not appear to follow a similar trajectory. Given that the relationship between sleep disturbances and sleepiness during pregnancy is understudied, we examined their associations to determine whether...

Diagnosis, management, and prevention of Crimean-Congo haemorrhagic fever: a Delphi-based consensus study in Türkiye

Background Crimean-Congo haemorrhagic fever (CCHF) is a widely distributed viral haemorrhagic fever with expanding geographic range. As new regions encounter the disease, clinicians must make high-stakes decisions despite limited standardised management frameworks. Methods In thi...

Refining genetic circuit design for enhanced type II polyketide biosynthesis in Escherichia coli

Polyketides represent a broad class of structurally diverse natural products with potent antibacterial and anticancer activities. Type II polyketide synthases (T2PKS) are multi-subunit complexes responsible for condensing acylated intermediates, including acetyl-CoA and malonyl-C...

The Hsd17b13P260S patient variant knock-in male mouse model provides translational insights into HSD17B13 biology

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disease that can progress to metabolic dysfunction-associated steatohepatitis (MASH), a condition marked by inflammation and fibrosis that increases the risk of cirrhosis, liver failu...

Longitudinal dynamics of serum IL-33 and sST2 across age and sex in a healthy Finnish cohort before and after Tdap booster vaccinations

Background Interleukin-33 (IL-33) and soluble ST2 (sST2) are critical regulators of tissue-derived inflammation, and their dysregulation is usually implicated in various inflammatory disorders. Despite this, how these circulating proteins behave over time in healthy individuals r...

Machine learning-based prediction of morphophysiological, ionic, and biochemical responses of Lolium multiflorum to salinity stress

Salinity is a major constraint on the establishment and productivity of annual ryegrass ( Lolium multiflorum Lam.). This study evaluated the effects of NaCl stress on the germination, growth, mineral composition, and biochemical responses of four annual ryegrass cultivars (‘Grass...

The Effect of Repeated Bilateral Deep Parasternal Intercostal Plane Catheter Boluses on Analgesia After Cardiac Surgery: A Randomized Controlled Trial

BACKGROUND: Median sternotomy for cardiac surgery is associated with significant postoperative pain. We evaluated whether repeated ropivacaine boluses via bilateral deep parasternal intercostal plane (DPIP) catheters improve analgesia after cardiac surgery. METHODS: In this rando...

Integrated single-cell transcriptomic, proteomic, and tissue-level analysis defines cancer-associated fibroblast programs in pseudomyxoma peritonei

Pseudomyxoma peritonei (PMP) is an ultra-rare mucinous neoplasm with extensive stromal remodeling, yet the role of cancer-associated fibroblasts (CAFs) remains poorly defined. A PMP-derived CAF culture was established and characterized through multiple omics and phenotypic assays...

Pathogens in the Nasopharynx Before and After Antibiotic Treatment for Acute Otitis Media

BACKGROUND: Limited data exist on whether the timing or duration of treatment for acute otitis media (AOM) affects nasopharyngeal carriage. We studied the eradication of pathogens (Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis) in relation to timing (...

Shotgun Metagenomic Analysis Reveals Taxonomic and Functional Transitions in the Salivary Microbiome During Periodontal Disease Progression

ABSTRACT Aim To characterise multi‐kingdom salivary microbiome profiles across clinically defined periodontal states and identify stage‐specific taxonomic and functional alterations using shotgun metagenomic sequencing. Materials and Methods In this cross‐sectional study, 204 adu...

Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core

ABSTRACT Selective RNA cleavage could provide versatile options in therapeutic applications. In this study, multivalent RNA‐cleaving agents, featuring 1,5,9‐triazacyclododecane or guanidine groups as catalytic centers, were synthesized on a cubic octameric silsesquioxane (COSS) c...

Time-dependent effect of isotretinoin use on oral health related quality of life in acne vulgaris patients: a longitudinal study

Abstract Background This longitudinal designed study evaluated the impact of systemic isotretinoin use on oral health-related quality of life (OHRQoL) through its effects on clinical periodontal parameters, salivary flow rate, and patient-reported oral symptoms. Methodology Twent...

Clinical impact of second radiotracer injection after failed lymphoscintigraphy in breast cancer sentinel lymph node biopsy: a retrospective cohort study

Abstract Background Sentinel lymph node biopsy (SLNB) is the standard method for axillary staging in breast cancer. To ensure the identification of sentinel lymph nodes (SLNs), lymphoscintigraphy (LS) is often used. However, failure of LS remains a clinical challenge. A second tr...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...

Prediction of platinum-based neoadjuvant chemotherapy response in muscle-invasive bladder cancer using a multifaceted approach

Abstract Radical cystectomy (RC), preceded by platinum-based neoadjuvant chemotherapy (NAC), is recommended for eligible patients with muscle-invasive bladder cancer (MIBC). Although NAC improves survival, many patients do not respond; in non-responders, it may delay surgery and...