University of Tsukuba

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy

In this Perspective, 2026 Albert Lasker Basic Medical Research Award winners Emmanuel Mignot, MD, PhD, and Masashi Yanagisawa, MD, PhD, discuss their identification of the brain peptide orexin and how it relates to sleep, specifically orexin deficiency and narcolepsy.

Titanosaur eggshells from the latest Cretaceous of Patagonia, Argentina: implications for nesting at high latitude

Abstract Dinosaur egg remains are rarely found in areas of high palaeolatitudes, with Canada (approx. 57–60° N) and Siberia (approx. 70–75° N) yielding the most polarward occurrences. Here, we describe dinosaur eggshells from the Upper Cretaceous (Maastrichtian) Chorrillo Formati...

Spin magnetic moments in the half-metallic ferromagnet—ferromagnet interface region detected by depth-resolved x-ray magnetic circular dichroism

We study spin magnetic moments near half-metallic Co2FexMn1−xSi (CFMS)/metal interfaces using depth-resolved x-ray magnetic circular dichroism (XMCD) and analyze their robustness against thermal fluctuations. We prepare epitaxial magnetic multilayered films with CFMS/CoFe and CFM...

Structure-Guided Enhancement of High-Temperature Thermoelectric Performance in Molten-Salt-Derived Weathered Biotite for Waste-Heat Recovery

Abstract Thermoelectric materials capable of operating at 600–900 °C are attractive for recovering industrial and nuclear waste heat toward a carbon-neutral society. Here, we report the structure-guided enhancement of high-temperature thermoelectric performance in natural weather...

Association Between General Physical Debilitation and Competitive Integrated Employment Outcome among Vocational Rehabilitation Clients with Arthritis, Cancer, Multiple Sclerosis, and Parkinson's Disease

Background Fatigue, pain, and weakness are common across chronic conditions and may restrict employment; however, their relationship to employment outcomes remains unclear. Objective To examine the association between general physical debilitation (GPD) and competitive integrated...

A bibliometric-systematic review of CGM’s application in lifestyle and behavioral research among healthy individuals: proposing a novel typology

Abstract Background Blood glucose management has progressed from diabetes treatment to tracking trends in healthy populations since the introduction of continuous glucose monitoring (CGM) in 1999. Previously, this population was difficult to study using traditional self-monitorin...

Kinetic Monte Carlo–Ising Machine Optimization for Atomistic Inverse Design of Solid Electrolytes

Abstract Maximizing ionic conductivity remains a fundamental challenge in the atomistic design of solid electrolytes. To this end, we present a framework that combines kinetic Monte Carlo (KMC) and factorization machine with quadratic-optimization annealing (FMQA), an Ising-machi...

Thermal decomposition and dehydration mechanism of kurnakovite MgB3O3(OH)5·5H2O

Abstract The thermal decomposition and dehydration mechanism of kurnakovite MgB3O3(OH)5·5H2O, a hydrated Mg borate mineral with potential industrial applications, were investigated using thermal analysis, in-situ high-temperature synchrotron single-crystal X-ray diffraction (30–1...

Self-organization of vascularized muscle from bovine embryonic stem cells

Abstract Cultured beef offers a promising alternative to traditional meat. While adult stem cells are commonly used as the cell source for cultured beef, their proliferation and differentiation capacities are limited. Current manufacturing processes for cultured beef steaks often...

Two distinct domains in mouse IG-DMR of the Dlk1–Dio3 locus confer imprinted DNA methylation in transgenic mice

Abstract Faithful maintenance of allele-specific methylation at imprinting control regions (ICR) is essential for genomic imprinting. Using transgenic mice (TgM), we investigated sequence requirements for paternal methylation acquisition and maternal hypomethylation maintenance d...

Tactile length-memorisation training for needle depth control: A pilot study of cross-postural skill transfer

OBJECTIVE: The aim of this pilot study was to examine whether tactile length-memorisation training practised in a single basic posture could improve insertion-depth control across different needling postures. METHODS: In this single-group pre-post pilot study, eight visually impa...

Isotopic evidence for slab-derived magmatic water beneath the Kussharo Caldera, Japan

It is well known that water transported by a subducting oceanic plate (slab) plays a key role in the formation of island-arc magmas. However, direct evidence demonstrating that magmatic water is derived from the slab remains limited. To address this, we conducted isotope and diss...

Stable isotope depletion and lithium enrichment due to accumulation processes in a structural controlled geothermal field : Evidence of meteoric water heated at shallow reservoir depths in the Sipoholon geothermal area, North Sumatra, Indonesia

The Sipoholon geothermal area in North Sumatra, Indonesia, is located within a tectonically active pull-apart basin in the central segment of the Sumatra Fault System, providing an excellent setting to investigate isotopic depletion and lithium (Li) enrichment in a structurally c...

Relationships between psychosocial aspects of stuttering and self-disclosure of stuttering in a Japanese sample

Purpose: We aimed to psychometrically evaluate a Japanese version of the Disclosure of Stuttering Scale, from Boyle et al. (2018), and identify the psychosocial factors associated with level of stuttering self-disclosure among adults who stutter. Methods: Adults who stutter were...

Road-oriented attention and class-balanced learning for post-disaster road damage segmentation

Accurate pixel-level segmentation of post-disaster road damage is important for decision-support applications that require reliable and spatially explicit road-scene understanding. This study proposes a deep-learning framework for localizing visible road-damage regions in post-di...

Unusual enrichment of rare C-to-G transversions in the SARS-CoV-2 delta spike

SARS-CoV-2 evolution is typically characterized by strong mutational biases, with C-G transversions being consistently rare. This study investigates a unique violation of this constraint specifically within the Delta variant spike protein. By analyzing nucleotide substitution spe...

MLAC: MicroED-assisted ligand structure analysis in complexes and its application to hERG-ligand complexes

Accurate determination of ligand structures in protein-ligand complexes is essential for elucidating molecular recognition mechanisms and advancing structure-based drug discovery. Cryogenic electron microscopy (cryo-EM) has emerged as a powerful technique for determining macromol...

Dual control of bedding structure on catchment hydrology: the interplay between direct bedding-parallel recharge and indirect landslide-driven drainage in steep accretionary complexes

Empirical understanding of how geological bedding structure governs catchment hydrology is limited, particularly in high-relief, landslide-prone mountains at the meso-scale (10- 1-100 km2), a range relevant to large-scale sediment disasters. This study evaluates the dual control...

AI analysis of elastin staining sections reveals the biological implications of cancer-related fibrosis in small-sized lung adenocarcinomas

Objective: Pathological invasion influences patient prognosis in lung adenocarcinoma (LUAD); however, diagnosis is often associated with high interobserver variability because non-lepidic adenocarcinoma (NLA) and cancer-related fibrosis (CRF) are intricately mixed, and CRF contai...