University of Rochester Medicine

Reliability of computational versus noncomputational metrics of working memory and episodic memory in serious mental illness.

= 76). These participants were tested in working memory and episodic memory paradigms. We applied a computational model that yielded parameters corresponding to memory storage capacity, memory precision, and the rate of attention lapses. We also examined a noncomputational metric...

Performance and Time Efficiency of Artificial Intelligence‐Based Programs for the Automatic Design of Occlusal Devices and Restorations: A Systematic Review

ABSTRACT Objective To evaluate the accuracy and time efficiency of artificial intelligence (AI)‐based programs for designing occlusal devices and tooth‐supported restorations. Material and Methods A search was completed in 5 databases: PubMed/Medline, Scopus, Embase, Web of Scien...

Landscape of approaches for streamlining pre-analytical and early analytical variables for solid tumor next-generation sequencing: A Genomics Organization for Academic Laboratories consortium report

The scope of pre-analytical and early analytical methods used in clinical molecular laboratories can have vast effects on the quality and turnaround time for solid tumor next-generation sequencing assays. To learn more about various approaches, a survey of 24 academic laboratorie...

Performance of the iBox Prognostication System in African American Kidney Transplant Recipients

Background: The iBox is a validated prognostication system that predicts long-term death-censored graft loss in kidney transplant recipients, but its performance in the specific population of African American recipients has not been fully studied. Methods: We conducted a multicen...

Management strategies in endogenous fungal endophthalmitis: a multi-institutional retrospective cohort study

Background/aims Standardised treatment guidelines for endogenous fungal endophthalmitis (EFE) are lacking. The purpose of this study is to describe treatment strategies and clinical outcomes of eyes with EFE. Methods Retrospective cohort study performed at eight academic institut...

What is the association between insulin dependence and the incidence of postoperative complications, perioperative glucose control, and five-year reoperation rates after total joint replacement?

Aims: Diabetes mellitus (DM) is associated with adverse outcomes following total hip arthroplasty (THA) and total knee arthroplasty (TKA), yet optimal perioperative risk stratification remains unclear. This study evaluated the association of insulin dependence with: 1) 90-day com...

Do patterns of perineural invasion improve risk stratification in prostate cancer? A narrative review.

The presence of perineural invasion (PNI), typically defined as direct contact between cancer cells and nerves, is a well-established adverse prognostic factor following definitive treatment when identified on prostate needle core biopsy. In contrast, there are mixed data regardi...

Talquetamab for people living with relapsed/ refractory multiple myeloma: plain language summary of the MonumenTAL-1 study

Plain Language SummaryWhat is this summary about?This summary describes how well talquetamab worked and its safety at a median (midpoint) of 17–26 months follow-up from the MonumenTAL-1 study, which tested talquetamab treatment for a type of cancer called relapsed/refractory mult...

Decisions to Disclose Suicide Attempt History: A Qualitative Study

Individuals with a history of suicide attempt may face complex decisions about whether, when, and how to disclose their suicidal behavior history. However, little is known about how they navigate these decisions within family, social, and mental health care contexts. This qualita...

A Call to Action to Improve Rates of Lymph Node Sampling During Wilms Tumor Resection

Failure to perform lymphadenectomies for patients with Wilms tumor (WT) was recognized as a practice gap by the American Pediatric Surgical Association in 2018. An educational campaign was conducted to promote lymphadenectomy. We sought to evaluate the national patterns of lymph...

Immune checkpoint molecules as biomarkers of Staphylococcus aureus bone infection and clinical outcome

Abstract Background Staphylococcus aureus prosthetic joint infections (PJIs) are broadly considered incurable, and clinical diagnostics that guide conservative vs. aggressive surgical treatments don’t exist. Understanding the human T cell response to chronic S. aureus osteomyelit...

Comparative proteomic analysis of environmental and genetic models of Parkinson’s disease highlights the role of purine metabolism

Parkinson’s Disease (PD) is the second most common neurodegenerative disease, with many cases attributed to environmental exposures. Paraquat (PQ), is a pesticide and neurotoxicant strongly associated with increased PD risk. PQ is a weak inhibitor of complex I of the electron tra...

Study protocol for first national vasa previa perinatal registry

Vasa previa is a rare but potentially catastrophic obstetric condition characterized by unprotected fetal blood vessels over or adjacent to the internal cervical os. Although advances in prenatal ultrasound have dramatically improved neonatal survival through planned cesarean del...

Translational insights and clinical challenges of targeting cancer stem cells

Abstract Cancer stem cells (CSCs) are tumor cell subsets with self-renewal, multilineage differentiation, and tumor-initiating capacity that sustain cancer initiation, progression, metastasis, and relapse. Targeting CSCs therefore represents a promising route to improve the durab...

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

BACKGROUND: Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood-onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult-derived paradigms. OBJECTIVE: To identify key gaps in the...

UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis

Metastatic dissemination is the principal cause of death in pancreatic ductal adenocarcinoma (PDAC), yet the molecular determinants that enable this process remain poorly understood. Here, we identify the axon guidance receptor UNC5B as a central regulator of PDAC metastasis. Usi...