University of Pittsburgh

Microbiome Targeted Therapies for Primary Sclerosing Cholangitis

Primary sclerosing cholangitis is a rare, progressive cholestatic liver disease of the intrahepatic and extrahepatic bile ducts with poor prognosis. The only life-extending treatment for PSC is liver transplantation, with up to 25% of post-transplant patients developing recurrent...

Cosmological Constraints from Full-scale Clustering and Galaxy–Galaxy Lensing with DESI DR1

Abstract We present constraints on cosmic structure growth from the analysis of galaxy clustering and galaxy–galaxy lensing with galaxies from the Dark Energy Spectroscopic Instrument (DESI) Data Release 1. Our analysis includes four samples drawn from the Bright Galaxy Survey (B...

Immobilized Neuroglobin Scavenges Carbon Monoxide From Circulating Carboxyhemoglobin

Carbon monoxide (CO) poisoning is responsible for around 50,000 emergency department visits per year in the United States alone. Currently, there is no available antidote for CO poisoning. We have previously developed an antidotal therapy based on an engineered hemeprotein, human...

Robust Melting Depression in Cu–Ag Despite Endothermic Mixing

Abstract Cu–Ag exhibits a melting depression despite endothermic mixing and limited solid solubility. We combine density functional theory (DFT), machine-learning interatomic potentials, and large-scale two-phase coexistence simulations to resolve its composition-dependent meltin...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Causal Relationship Network of Risk Factors Impacting Workday Loss in Underground Coal Mines

Purpose: To explore relationships with post-event workday loss in U.S. underground coal mines using Grouped Greedy Equivalence Search (GGES), a prior-knowledge-constrained extension of GES. Methods: The analysis utilizes data obtained from the National Institute for Occupational...

Machine Learning on Heterogeneous, Edge, and Quantum Hardware for Particle Physics

The next generation of particle physics experiments will face an era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing these data for scientific discovery demands real-time infere...

Interrupted Time Series Analysis of the Efficacy of Bilingual Abstract Semantic Associative Network Training

Purpose: In response to the need for more appropriate anomia treatment materials for bilingual persons with aphasia (BPWAs), we have created linguistically and culturally appropriate versions of AbSANT (Abstract Semantic Associative Network Training) for several languages that we...

Care of the Sexual or Gender Minority Community Living with Cystic Fibrosis: A Survey of United States and Canadian Multidisciplinary Health Care Providers

PURPOSE: Lesbian, gay, bisexual, transgender, queer, intersex, asexual, or another sexual or gender minority (LGBTQIA+) people face health inequities and commonly report health care avoidance. We examined how multidisciplinary subspecialist providers care for LGBTQIA+ people with...

Perspectives on Gender Equity: A National Survey of Pediatric Hospital Medicine Division Leaders

OBJECTIVE: To assess pediatric hospital medicine (PHM) division leaders' perspectives on gender equity in their divisions and organizations. METHODS: In 2025, we conducted a cross-sectional Research Electronic Data Capture survey distributed via email to 236 PHM division leaders....

Phenotypically diverse Klebsiella pneumoniae urinary tract infection isolates consistently cause pyelonephritis

ABSTRACT Urinary tract infections (UTIs) are a significant public health burden that impact millions of people every year and are highly prevalent among hospital-acquired infections. Klebsiella pneumoniae is globally the second most common cause of UTIs after uropathogenic Escher...

Kynurenine Pathway Activation is Associated with Poor Sleep Efficiency in Men With HIV

Background: Sleep disturbances are common in people with HIV, yet the underlying biological mechanisms remain poorly understood. Chronic immune activation in HIV can induce the tryptophan-kynurenine (TK) pathway, which both reduces melatonin synthesis and increases production of...

Joint Modeling of GD-1 and C-19 as Old Streams

Abstract DESI observational data for the GD-1 and C-19 streams are compared to stream simulations in an evolving multihalo potential of a Milky Way–like galaxy based on a cosmological Milky Way–like simulation. The number of subhalos decreases with time, and the subhalo-stream en...

Engineering judgment: undergraduate epistemologies

Engineering judgment is a crucial competency present in ABET’s outcomes. However, a consensus-driven definition for it was only recently published in the education literature, with limited formal instruction and assessment to date. Therefore, the present study used this definitio...

Opioid antagonists for overdose reversal in the era of synthetic opioids: a scoping review of high-dose naloxone and nalmefene

Opioid overdose deaths in the United States have surged over the past two decades, driven largely by the proliferation of illicitly manufactured fentanyls (IMFs). Concerns that standard naloxone doses may be insufficient for reversing IMF-related overdoses have prompted FDA appro...

Silent signals: Understanding how patient-provider communication impacts the post-acute care experiences of older adults

Date presented: April 24, 2026 Primary Author and Speaker: Dominique H. Como, dhc30@pitt.edu

Feminist anthropologies in the contemporary world: A conversation on theory, praxis, and politics

Abstract This article brings together the voices of members of three major feminist anthropological associations to discuss the state of feminist anthropology as a distinct subfield of anthropology, as well as its state of affairs as an increasingly expanding, as well as increasi...

Household‐level health and economic spillover effects associated with adult epilepsy in the United States

Abstract Objective Epilepsy is associated with substantial health‐related and economic burden, and prior spillover research has largely focused on caregivers. Little is known about the impact of epilepsy on other adults living in the same household. This study examined household‐...

Partnering With Generative Artificial Intelligence for Quantitative Data Analysis in Nursing Research: A Practical Workflow for Ethical Collaboration

Reproducibility and replicability are our scientific and ethical mandate, and the foundation of trust in nursing science and research. Both rest on transparent documentation of how data were actually analyzed. The rising use of generative artificial intelligence (GenAI) in resear...

Evaluating a Near-Peer Facilitation Model for Simulation-Based Education in Occupational Therapy

Date presented: April 23, 2026 Primary Author and Speaker: Malachy James Clancy, malachy.clancy@jefferson.edu