University of Pisa

Diosmin Attenuates Age-Associated Vascular Oxidative Stress and Endothelial Dysfunction in Aged Rats

Vascular aging is driven by a self-sustaining interplay between oxidative stress and chronic low-grade inflammation, collectively referred to as inflammaging. Diosmin, a citrus-derived flavonoid with antioxidant and anti-inflammatory properties, has not previously been investigat...

Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence

BACKGROUND: Short-term studies have demonstrated that single-pill combinations (SPCs) improve adherence, reduce hypertension-related complications, and lower costs; however, long-term benefits remain unclear. This study compared adherence, healthcare resource utilization (HCRU),...

Medical Laboratory Technologists’ Perceptions of Laboratory Information Systems

Laboratory Information Systems (LIS) are essential for managing laboratory workflows, yet their effectiveness depends on user acceptance. This study examined Medical Laboratory Technologists’ (MLTs’) perceptions of LIS in Indonesian laboratories. This sequential explanatory mixed...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Florbetaben PET for early and non-invasive diagnosis of light chain amyloidosis: a case report and brief review of the literature

Light chain amyloidosis is a hematological disease requiring rapid diagnosis and urgent therapeutic intervention. The confirmation of the clinical suspicion demands invasive methods, in order to demonstrate histological involvement of organs. Substantial efforts are required espe...

The Role of Direct-Acting Antivirals (DAAs) in Hepatitis C Virus-Associated Lymphoproliferative Disorders

Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis, affecting approximately 50 million people worldwide. An estimated 15–30% of individuals with chronic HCV infection progress to cirrhosis, which may subsequently develop into hepatocellular carcinoma. Beyond...

Detailed study of non-equilibrium characteristics of quasi-neutral TNSA plasmas

In an experiment performed in November 2022 at the petawatt (PW) laser facility at Vega III located in Salamanca-Spain, we have studied the successful production of several radioisotopes using protons accelerated by the Target Normal Sheath Acceleration (TNSA) mechanism (Rodrigue...

Turrill’s Omega: A Heuristic Index for Quantifying the Support of a Taxonomic Hypothesis

Biological research relies on the use of taxa, with species expressed in the form of a Latin binomial. Although taxa are commonly regarded as established entities, they actually represent hypotheses on the distribution of natural biological variation and may change their status a...