University of Pisa

Host-Specific Circulation and Molecular Diversity of Babesia, Hepatozoon and Bartonella Species Among Wild Carnivores in Northwestern Italy

Vector-borne diseases (VBDs) represent a concern for animal and public health, and wildlife surveillance is valuable for their monitoring. The occurrence, molecular diversity and host distribution of tick-borne protozoa (TBP: Babesia spp., Theileria spp. and Hepatozoon spp.) and...

Some Remarks on Singular Capillary Cones with Free Boundary

Abstract We study singular minimizing capillary cones with free boundary. We provide a stability criterion à la Jerison–Savin and use it to prove that a minimizing capillary cone is flat when its free boundary mean curvature is non-negative and $$n\le 4$$ n ≤ 4 , or non-positive...

A Granger causality-guided multi-graph transformer framework for traffic flow forecasting

Accurate traffic forecasting is challenging because of the difficulty of capturing time-varying propagation and multi-scale spatio-temporal interactions. Most existing deep learning models only learn correlations rather than directional dependencies, which limits interpretability...

Menopause hormone therapy in women with cardiovascular risk factors or established ischemic heart disease: A joint FIGO and WHF position paper

Extending women's health-span is a key challenge for the medical community. Although women live longer than men, they face a higher burden of chronic diseases, such as cardiovascular diseases (CVDs) and disabilities. Endogenous estrogens appear to benefit cardiovascular health, a...

Construction and characterisation of the DarkSide-20k veto silicon photo-multiplier tiles

Abstract Silicon photo-multipliers (SiPMs) are state-of-the-art sensors capable of detecting a single photoelectron under cryogenic conditions, with potentially lower radioactivity than widely used photomultiplier tubes. The DarkSide-20k experiment, designed to perform direct dar...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Computing the Density of the Kesten–Stigum Limit in Supercritical Galton–Watson Processes

Abstract. This paper proposes a novel numerical method for computing the density of the Kesten–Stigum limit random variable associated with a supercritical Galton–Watson process. This random variable captures the cumulative effect of early demographic fluctuations and determines...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

On the data-sparsity of the solution of Riccati equations with applications to feedback control

Abstract Solving large-scale continuous-time algebraic Riccati equations is a significant challenge in various control theory applications. This work demonstrates that when the matrix coefficients of the equation are quasiseparable, the solution also exhibits numerical quasisepar...

The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry

Abstract Aims The right ventricle (RV) is a major determinant of outcome in pulmonary arterial hypertension (PAH), but its assessment has not been completely incorporated in the risk of mortality scores. We therefore evaluated the added value of echocardiography of the RV to risk...

Smartphone-Based Estimation of Ground Reaction Forces and Lower-Limb Kinematics During Functional Tasks Using OpenCap: A Feasibility Study

(1) Background: Markerless motion capture may enable scalable biomechanical assessment outside laboratory environments, yet its applicability to tasks involving elevated foot contacts and rapid loading transitions remains insufficiently characterized. This feasibility study evalu...

Protocol for identifying head direction cells in mice using in vivo extracellular recordings and juxtacellular labeling

Head direction (HD) cells are required for spatial orientation. Protocols that combine functional identification with anatomical recovery of single HD neurons remain technically demanding. We present a protocol for recording HD cells in awake, head-fixed mice using in vivo extrac...

Readiness Is Not Leverage: Latent-Field Geometry as Spatial Decision Support in Sustainable Regeneration

A key aspect of sustainability is regenerating inhabited urban areas without demolishing them, since this helps retain the embodied carbon and spatial capital built up in existing buildings while preventing the displacement that results from clearing land. In this approach, which...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

Electrolyzed Water as a Biocide in Premise Water Networks: A Narrative Review and a Conceptual Framework

Biocide usage in premises plumbing systems requires a multidimensional evaluation to ensure that all interfering factors are controlled and the microorganism presence is strictly limited or eradicated. Current research on electrolyzed water as a primary water biocide has been lim...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Comparative abiotic, regulatory-aligned assessment of nutrient and trace-metal release from secondary geomaterials for soil application

Abstract This study provides an abiotic, regulatory-aligned leaching assessment of two secondary geomaterials intended for soil application: RE.WO, a secondary raw material derived from the thermal transformation of mineral wool construction waste, and BO50, a by-product of rock-...

Impact of high-speed train vibrations on subsoil and built environment: Engineering-geological case studies from Poland

This engineering-geological study evaluates the vibrational impact of high-speed rail traffic on subsoil and its implications for future buildings, in the context of environmental protection and sustainable infrastructure development. The research concerned a planned high-speed r...

Expanding Oued Beht: Final Neolithic, Bronze Age, medieval and later discoveries from excavation and survey in 2023

Abstract Oued Beht, Morocco, is emerging as a key site for understanding later prehistory in the northwestern Maghreb. Previous fieldwork by the Oued Beht Archaeological Project (OBAP) in 2022 revealed major evidence of a large and complex focus of activity across the ridge durin...

Lower-crustal unzipping drives active orogenic deformation

The Apennines-Tyrrhenian Sea system allows us to investigate seismotectonics in coupled thrust belt and back-arc realms driven by subduction retreat, continental collision, and crustal delamination. Since the late Miocene, active extension has progressively migrated forelandward,...