University of Perugia

A Physical Therapy Clinical Framework for Temporomandibular Disorders: Integrating DC/TMD, ICOP and Multidimensional Patient Phenotyping

Temporomandibular disorders (TMDs) are clinically heterogeneous, and patients sharing the same diagnosis may differ substantially in pain mechanisms, functional impairments, behavioral contributors, comorbidities, psychosocial burden, prognosis, and treatment response. Although t...

The α-Mooney–Rivlin model of hyperelasticity

Abstract We introduce the α-Mooney–Rivlin model, a three-parameter generalization of the classical Mooney–Rivlin law based on a new pair of α-dependent invariants for incompressible hyperelasticity. The model preserves the transparent two-term structure of the classical formulati...

ADHD Presentations and Severity in Adults: Psychometric Profiles, Psychiatric Comorbidities, and Emotional Dysregulation in Relation to Psychiatric Hospitalization

Background/Objectives: Attention-deficit/hyperactivity disorder (ADHD) in adults is heterogeneous in symptom presentation, severity, and comorbid psychopathology, yet systematic data from Italian clinical populations remain limited. Methods: In this retrospective, cross-sectional...

Toward a Local Manipulation of DNA by Quantum Fields

Abstract Hydrogen bonds are the fundamental backbone for deoxyribo-nucleic acid (DNA) stability. In this Letter we investigate a new strategy based on plasmonic cavities to perform manipulation of hydrogen bonds in DNA. The analysis is performed using state-of-the-art Quantum Ele...

Development of Sustainable Thermoplastic Zein by Partial Substitution of Glycerol with Olive Oil or Oleic Acid: a New Route for Injection-Molded Biopolymers

Thermoplastic zein formulations containing 25 wt% total modifier were processed by extrusion and injection molding. Glycerol was progressively replaced with oleic acid (OA) or olive oil (OO) at substitution levels ranging from 2.5 to 10 wt%, while maintaining the zein and total m...

Cell Wall Phenolic Composition and Characterization of the CSE and F5H Genes in Eragrostis curvula Cultivars

Eragrostis curvula (Schrad.) Nees is a C4 perennial grass used as forage in semiarid regions, and its quality varies among cultivars. Given the limited variation in total lignin content among genotypes, cell wall phenolic composition may be a more relevant source of variation. Th...

The role of early genetic diagnosis in drug-resistant epilepsies: analysis of SCN1A, SCN2A and SCN8A gene mutations through salivary genetic testing

Abstract Background Epileptic and/or developmental encephalopathies (DEEs) represent a particularly severe subgroup of early-onset epilepsies, with an identifiable genetic aetiology in 30–50% of cases. Mutations in the SCN1A , SCN2A , and SCN8A genes, encoding the α-subunits of t...

Digital Device Use and Hand–Wrist Disorders: A Scoping Review

The widespread use of smartphones and electronic devices has raised concerns about their impact on hand and wrist health. This scoping review synthesised current evidence on musculoskeletal and soft-tissue disorders associated with device use. Thirty-two studies were included, ex...

Conservative Management of Pediatric Mandibular Condylar Fractures: A Systematic Review

ABSTRACT Mandibular condylar fractures are common mandibular injuries in children. Conservative treatment is generally favored because of the remodeling capacity of the growing condyle, although rehabilitation protocols and the criteria for operative treatment remain variable. Th...

The magneto-elastic instability of Kirchhoff rings

Abstract Understanding the interplay between electromagnetic forces and elasticity is a fundamental problem in the mechanics of deformable structures, particularly when electrical currents interact with magnetic fields to generate distributed body forces. A paradigm for this prob...

Lifelong health leadership: reframing geriatrics as a model of care for resilient health systems

Abstract Population ageing is commonly framed as a demographic challenge, biological frontier, or economic pressure. Yet these perspectives remain incomplete unless longevity is also understood as a leadership challenge. Gains in lifespan have not been matched by equivalent gains...

Patient Satisfaction and Perceived Stress in Digestive Endoscopy

OBJECTIVE: To evaluate patient satisfaction and perceived stress among adults undergoing diagnostic digestive endoscopy in Italy and to examine their associations with sociodemographic, clinical, and procedural factors. BACKGROUND: Patient satisfaction is a key indicator of endos...

Unlocking the Potential of Biomass Residues for the Sustainable Synthesis of Photocatalysts for H2 Generation

Biomass-derived materials are attracting increasing interest for photocatalytic photoreforming due to their ability to function as photocatalysts, co-catalysts, supports, templating agents, and green reducing agents. This review examines recent advances in the development of biom...

Trends in artificial intelligence-generated and -assisted content in comment pieces in The Lancet Regional Health, 2020–2025: a longitudinal study and citation impact analysis

Abstract Background Large language models (LLMs) are now widely used in numerous text-generation exercises. This trend raises important questions about the scientific literature and the effectiveness of editorial checks. This study aimed to measure the frequency of artificial int...

Real-world adjunctive use of an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes in drug-resistant epilepsy: the multicentre retrospective ARMILLA study

The purpose of this study was to describe real-world adjunctive use, tolerability, and hypothesis-generating seizure and multidomain outcomes of LALBAAY, an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes (FSMP), in patients with drug-resistant epilepsy (DRE)....

Association of the 5-item modified frailty index and chronological age with postoperative length of stay after CRS–HIPEC: a single-centre cohort study

Frailty assessment may inform selection for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS–HIPEC), but its association with hospitalization in functionally selected patients remains uncertain. To evaluate the association of the 5-item modified frailty i...

Surface Termination Unlocks Photocatalytic Potential: Reshaping Structure and Electronics in Ultrathin MoS 2 /TiO 2 Heterojunctions

Anatase TiO 2 stands out for its exceptional chemical stability, nontoxicity, and robust photocatalytic capabilities; however, its intrinsically wide bandgap severely restricts its activity to the ultraviolet spectrum, limiting practical efficiency under solar illumination. To ci...

Impact on blood cultures pre-analytical quality and positivity rate of a key performance indicators digital monitoring approach: a pre–post intervention study

Blood cultures (BCs) remain essential for diagnosing bloodstream infections, but their yield depends largely on pre-analytical phase quality. We evaluated the impact of an intervention guided by a digital platform for blood culture key performance indicators (KPIs) automated extr...

Activities of the Animal Welfare Body at the Istituto Zooprofilattico Sperimentale Umbria and Marche “Togo Rosati” from 2016 to 2025

Animal welfare and ethical responsibility are central considerations in animal research. In Italy, European Directive 2010/63/EU was implemented through Legislative Decree No. 26/2014, establishing Animal Welfare Bodies (AWBs) to ensure ethical project evaluation and promote the...

From straw waste to circular composites: A systematic comparison of untreated fillers in PBS, PBAT and their blends through performance, morphology and sustainability assessment

In this study, wheat straw (WS) and rice straw (RS) were added up to 30 wt% in maleic anhydride grafted polybutylene succinate (PBS) and poly(butylene adipate-co-terephthalate) (PBAT) using a co-rotating twin-screw extruder. Injection molded samples were analyzed using tensile, f...