Institution
University of Perugia
Recent research
- Health & MedicineOpen access
Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...
- Climate & EnvironmentOpen access
Integrating in–situ data and remote sensing for the spatiotemporal assessment of alpine vegetation
Abstract Alpine plant communities are structured by fine–scale interactions among soil properties, topography and microclimatic conditions, but these gradients are difficult to monitor consistently across space and time. Field observations provide the ecological reference needed...
- Health & MedicineOpen access
Digital twins in neuroscience: A narrative review of technical challenges for child neurology
Digital twins are dynamically updated, patient-specific computational representations that integrate multidimensional data to support prediction and clinical decision-making. This narrative review examines the conceptual foundations and enabling technologies of digital twins in n...
- BiologyOpen access
Genomic Diversity and Footprints of Selection in Hamdani Sheep
This study aimed to characterize the genomic diversity, population structure, and candidate regions consistent with selection in Hamdani (HAM) sheep using high-density SNP generated by double-digest restriction site-associated DNA sequencing (ddRADseq). A total of 20 animals were...
- BiologyOpen access
Oxaliplatin–fluoropyrimidine combinations are standard adjuvant therapy after radical resection of high-risk stage II and stage III colon cancer but expose many patients to toxicity while failing to prevent relapse in others. PEGASUS was a multicenter, single-arm, phase 2 trial e...
- Physics & SpaceOpen access
Causal Quantum Spacetime Theory (CQST): A Framework for Emergent Geometry and Its Observational Test
The Causal Quantum Spacetime Theory (CQST) treats spacetime as emergent from a discrete causal substrate, the quantum spacetime regenerating (QSR) lattice, assembling its geometric, holographic, quantum-foundational and phenomenological strands. The framework identifies the QSR l...
- Health & Medicine
Abstract Objectives To assess, for the first time, macrovascular, medium-calibre vessel, and microvascular damage in Sjögren’s disease (SjD) using carotid greyscale ultrasound (GSUS), retrobulbar colour Doppler ophthalmic artery (OA) ultrasound (RCDUS), and static retinal vessel...
- Society & Economics
Climate change generates uncertainty and insecurity, shaping human–environment relations and contributing to psychological distress, particularly in the form of worry and anxiety. While moderate levels of worry may foster adaptive responses, elevated worry and anxiety are associa...
- BiologyOpen access
Current–Voltage Characteristics of K+ Channels Estimated by MD Simulations and Markov State Models
Abstract Molecular dynamics (MD) simulations have yielded important insights into ion conduction in potassium channels, but quantitative comparison with electrophysiological experiments remains challenging. Due to their high computational cost, MD simulations are typically perfor...
- Climate & EnvironmentOpen access
Abstract Urbanisation is reshaping mammalian communities worldwide, yet forest specialists are generally considered poor urban adapters. The pine marten Martes martes , for long regarded as an indicator of intact woodlands, has recently shown signs of expansion into human-modifie...
- Health & Medicine
Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice
Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, thera...
- BiologyOpen access
Heavy metal contamination of agricultural soils and urban green spaces has become a major environmental concern, threatening ecosystem functioning, food safety, and sustainable land management. Silicon-based growing media have emerged as an environmentally friendly approach for r...
- Physics & SpaceOpen access
Shape coexistence in 94Zr from a model-independent analysis
Low-lying states of 94Zr were investigated via low-energy multi-step Coulomb excitation. From the measured γ-ray yields, 16 reduced E2 transition probabilities between low-spin states were determined, together with the spectroscopic quadrupole moments of the 2+1,2 states. Based o...
- Biology
Abstract The objective of this study is to evaluate racing performance of Thoroughbred yearlings following arthroscopic surgery for osteochondrosis (OC) of the femoropatellar (FP) and tarsocrural (TC) joints. This is a retrospective study of Thoroughbreds < 2 years old undergoing...
- Health & Medicine
Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event
BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...
- Health & MedicineOpen access
Background: Treatment of peri-implantitis remains challenging because biofilm removal from microstructured implant surfaces is often incomplete. The present study is an uncontrolled, prospective feasibility case series involving six patients (six implants), not a controlled clini...
- Engineering & TechnologyOpen access
This paper presents a structural health monitoring (SHM)–oriented framework for the nonlinear identification of friction pendulum isolators in a real base isolated school building. Based on a parametric investigation carried out for this study, which identifies the high-speed fri...
- Health & MedicineOpen access
JNK signaling regulates reproductive trade-offs after Plasmodium infection in the malaria mosquito
ABSTRACT Environmental stress can limit mammalian reproduction by affecting production of sexual steroid hormones. Here we reveal a similar mechanism in the malarial mosquito Anopheles gambiae : activation of the stress-sensitive c- J un N -terminal k inase, JNK, constrains repro...
- Health & MedicineOpen access
Background: Cancer pain remains highly prevalent and undertreated despite established guidelines. In Italy, Law 38/2010 mandates systematic pain assessment, yet only 26% of clinicians routinely evaluate pain at each clinical visit, and fewer than one-quarter have received formal...
- Engineering & TechnologyOpen access
Spent lithium‐ion batteries represent a growing environmental challenge, yet their transition‐metal‐rich cathodes remain largely underutilized as functional materials. We report a direct upcycling strategy in which LiCoO 2 cathodes recovered from end‐of‐life smartphones are trans...