University of Pavia

The Characterization of a Compact CLLB:Ce Scintillation Detector for Mixed-Field Monitoring at a Muon Facility

Compact scintillation detectors with simultaneous gamma and neutron sensitivity are increasingly relevant for mixed-field monitoring and nuclear measurements under size and cost constraints. This work characterizes a compact Cs2LiLaBr6:Ce (CLLB:Ce) detector with integrated SiPM r...

Mucoadhesive Nanoemulsions for Nose-to-Brain Delivery of Dimethyl Fumarate: Development, Characterization and Proof-of-Concept In Vivo Evaluation

Background: Dimethyl fumarate (DMF) is an approved therapeutic agent for the treatment of multiple sclerosis, known for its anti-inflammatory and neuroprotective properties. However, its oral administration is often accompanied by gastrointestinal side effects, limiting its thera...

Longitudinal health-related quality of life after electrochemotherapy in elderly patients with cutaneous melanoma

The incidence of cutaneous melanoma (CM) is increasing among elderly patients, who often present with advanced disease, including cutaneous metastases. Electrochemotherapy (ECT) is a local ablative treatment that enhances chemotherapy uptake via electric pulses. Management in pat...

Improving Meteorological Drought Forecasting Through a CPO ‐Tuned VMD ‐Liquid Neural Network

ABSTRACT This paper introduces a novel hybrid model for one‐month‐ahead meteorological drought forecasting. The proposed approach employs the Crested Porcupine Optimizer (CPO) to adaptively tune the key parameters of Variational Mode Decomposition (VMD). This optimization step ef...

Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations

Abstract Ampullary somatostatin-producing D-cell neuroendocrine tumors are rare neoplasms that may be associated with type 1 neurofibromatosis. The molecular features of sporadic ampullary somatostatin-producing D-cell neuroendocrine tumors (SAMSOM-NETs) remain poorly characteriz...

Zero-Dimensional Bismuth Halide Thin Films with High Orientation and Broadband Emission

Abstract Lead-free low-dimensional metal halides are emerging as highly tunable materials for optoelectronic applications. Here, we report a new class of zero-dimensional bismuth halides incorporating phenethylammonium (PEA) cations, namely PEA4BiI7 and PEA4BiBr7, and investigate...

A quantitative framework for ultrafast ptychography through digital twin control of extreme-ultraviolet beams

Ptychography is a powerful imaging method that has transformed microscopy at large-scale and laboratory facilities. Its combination with extreme-ultraviolet light has enabled tabletop microscopes that visualize nanoscale dynamics and characterize ultrafast pulses. However, the pe...

Friends or foes: Unraveling the tsetse fly-Spiroplasma symbiosis

Tsetse flies ( Glossina spp.) transmit African trypanosomes, the causative agents of human African and African animal trypanosomiases (HAT and AAT, respectively). These neglected tropical diseases impose significant public health and economic burdens across sub-Saharan Africa. Tr...

Performance Validation of PAN_CURVE, a Novel Artificial Intelligence Tool for the Automatic Detection of Panoramic Curves from CBCT X-Rays

Background/Objectives: Detecting panoramic curves is a critical step in dental imaging, as it serves as the foundation for generating high-quality panoramic radiographs from Cone Beam Computed Tomography (CBCT) scans. These curves trace the dental arch, ensuring that key anatomic...

Microbial adhesion promotes Piezo1 activation to initiate innate immunity

Abstract How mammals mount an effective immune response against infectious agents remains unresolved. Here we identify microbial adhesion to myeloid cells as a critical initiating event that precedes pattern recognition receptor (PRR) engagement. Using a skin infection model with...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

Optimization and Intra-Laboratory Validation of the Neuro-2a Assay for Tetrodotoxin Detection in Mussels

Tetrodotoxin (TTX) is a potent marine neurotoxin responsible for severe seafood poisoning in humans, characterized by neurological symptoms that may be fatal. Originally identified as a natural contaminant of pufferfish (Tetraodontidae family), over the last few years TTX and its...

Association Between Proton Pump Inhibitor Use and Gastric Neuroendocrine Neoplasms in Autoimmune Gastritis: A Real‐World Propensity Score‐Matched Study From the Autoimmune gastRitis Italian netwOrk Study grOup

ABSTRACT Background and Aims Autoimmune gastritis (AIG) is characterized by chronic hypergastrinemia and is associated with an increased risk of gastric neuroendocrine neoplasms (gNENs). Because proton pump inhibitors (PPIs) further increase gastrin secretion, concerns have been...

Eco-Emotion Profiles Among Parents and Links to Violent and Neglectful Parenting: Parental Burnout as a Mediating Pathway

Climate change is a psychosocial stressor with implications for parenting and child safety. Many parents experience eco-emotions that can tax caregiving resources and self-regulation, yet evidence is scarce on how eco-emotion profiles relate to parental burnout and violent and ne...

Relationships at work: friend or foe? The perspective of ADHD employees

Purpose Neurodivergent employees present unique and valuable abilities and skills for organizations, such as creative and innovative thinking. However, they still face barriers and considerable stigma in the workplace, which are associated with higher rates of unemployment and tu...

Signals of Communicative Intent Enhance the Impact of Emotional Messages from Human Speakers, While Effects for Robots are Attenuated

Abstract The present work investigated humans’ responses to robots’ verbal emotional expressions. To this end, the interplay of agent characteristics and signals of communicative intent on emotional word processing was examined. In two behavioral studies (N1 = 36, N2 = 72), parti...

Two-dimensional simulation of plastic bottles transport in a urban reach of the Arno River

Within the MINOSSE project (ManagINg plastic transpOrt in riverS and coaStal arEas), the 2D hydrodynamic numerical model ORSA2D_WT has been adapted to simulate the transport of plastic bottles, the most common macroplastic item transported in water bodies. Unlike smaller plastics...

Autochthonous chikungunya virus outbreak in Verona province, Italy, 2025

Abstract Background Chikungunya virus (CHIKV), primarily transmitted by Aedes mosquitoes, has increasingly caused autochthonous outbreaks in temperate regions, including Italy. In 2025, a local CHIKV outbreak occurred in Verona province, Veneto Region. We report the findings of i...

Cardinalities of Irredundant Bases of Finite Primitive Groups

Let [Formula: see text] be a finite permutation group acting on a set [Formula: see text]. An ordered sequence [Formula: see text] of elements of [Formula: see text] is an irredundant base for [Formula: see text] if the pointwise stabilizer of the sequence is trivial and no point...

When Plain Language Deceives: Frequent but Generic Words and Misleading Sentence Simplicity in a Mobile Phone Advertisement—An Eye‐Tracking and Decision‐Task Study

ABSTRACT This study investigates how plain and apparently simple language can mislead readers in online advertising. Using eye‐tracking and a forced‐choice task, we compared an original smartphone advertisement with a revised version. The revision replaced frequent and generic wo...