University of Pavia

Application of LHC gas recuperation systems for methane emission control in livestock housing

Abstract The CH4rLiE (CH4 Livestock Emission) project presents a dry-gas laboratory proof-of-principle for mitigating methane (CH4) emissions in livestock housing. This work investigates the technical feasibility of capturing CH4 at low concentrations by adapting gas recovery sys...

Multi-fidelity methods for kinetic models of epidemic dynamics with uncertain contact structure

In this work, we develop a multi-fidelity strategy for kinetic models in epidemiology with uncertain contact dynamics. Assessing and controlling the population-level effects of contact dynamics requires the development of models for understanding observable effects of heterogeneo...

Rethinking Solid-Phase Microextraction (SPME) for Bioanalysis: Workflow Optimisation in Automated Vacuum-Assisted Cooling SPME for Fatty Acid Monitoring in Faecal Waters

Short-chain fatty acids (SCFAs) are key biomarkers of gut microbiota and intestinal health, yet their analysis is challenging due to high volatility, hydrophilicity, and the complexity of the faecal matrix. This study introduces a novel, green, and fully automated workflow for mo...

Impaired Flow and Physiology in Coronaries With Anomalous Origin From the Opposite Sinus of Valsalva

BACKGROUND: Anomalous Aortic Origin of a Coronary Artery (AAOCA) high-risk anatomical features (intramural segment, acute take-off angle, slit-like ostium) cause coronary stenosis leading to myocardial infarction. How these features alter coronary physiology remains unclear. AIMS...

ADHD Presentations and Severity in Adults: Psychometric Profiles, Psychiatric Comorbidities, and Emotional Dysregulation in Relation to Psychiatric Hospitalization

Background/Objectives: Attention-deficit/hyperactivity disorder (ADHD) in adults is heterogeneous in symptom presentation, severity, and comorbid psychopathology, yet systematic data from Italian clinical populations remain limited. Methods: In this retrospective, cross-sectional...

Visible‐Light Cobalt‐Catalyzed Synthesis of Aroyl Amides From Arylazo Sulfones

A versatile strategy leveraging the peculiar reactivity of arylazo sulfones as substrates bearing dyedauxiliary groups in arylation processes, combined with the catalytic activity of Co 2 (CO) 8 in carbonylation reactions, enabled the efficient synthesis of aromatic amides. The p...

Genetic evidence for the psychosis continuum: polygenic score analysis

Background The psychosis continuum conceptualises psychotic phenomena as existing on a spectrum from subclinical experiences to psychotic disorders. Despite epidemiological and clinical evidence in support of this model, few studies have examined polygenic liability across the se...

S.A.F.E agentic: a trustworthy credit scoring system with a conversational platform

Credit scoring is an area where Machine Learning models should be evaluated not only for predictive performance, but also for fairness, explainability, and robustness as part of a broader trustworthy-AI governance process. This paper presents a SAFE agentic credit-scoring system...

Comparability of self-reported and accelerometer-based physical activity assessment in patients with facioscapulohumeral muscular dystrophy

Quantifying physical activity (PA) is clinically relevant in facioscapulohumeral muscular dystrophy (FSHD). Wearable accelerometers provide objective measures, whereas self-reported questionnaires are a widely used, cost-effective alternative. However, their comparability in FSHD...

Fluctuating diffuse-interface simulations of vapor nucleation: Effects of wall superheat, wettability, chemical heterogeneity, and nanoscale topography

Surface modification affects both vapor formation and the heat transferred from a heated wall. These effects must be considered together when assessing surfaces for boiling applications. This study compares the effects of wall superheat, uniform wettability, chemical patterning a...

Adaptive feedforward construction method for precision motion stage based on iterative learning control

Feedforward compensation strategy is becoming increasingly important on improving control performance of the modern ultra-precision motion stages since the motion stages behave more flexible dynamic characteristics increasingly. Among numerous feedforward compensation strategies,...

Simplification and Derivatization of Quinoline-Containing M41 Lead to the Discovery of NADPH Oxidase Isoform-Selective Inhibitors Effective in Cancer Cells

Abstract NADPH oxidases (NOXs) are attractive but challenging drug targets. Starting from M41 and its analog MC4876, we synthesized quinoline-based derivatives. SAR studies revealed that modifications at the quinoline C2 position and the amine-moiety influenced potency and isofor...

Virtual element approximation of eigenvalue problems: Is the stabilization of the right hand side necessary?

The VEM approximation of eigenvalue problems usually involves the appropriate tuning of stabilization parameters, unless self-stabilizing or stabilization-free VEM are used. In this paper we prove that for elliptic self-adjoint eigenvalue problems the stabilization of the mass ma...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Circulating Metalloproteinase Inhibitors and Artificial Intelligence–Derived Radiomics Predict Persistent Endoleak After Endovascular Abdominal Aortic Aneurysm Repair: A Multimodal Biological-Imaging Model

Objective: Persistent endoleak after endovascular abdominal aortic aneurysm repair (EVAR) reflects ongoing aneurysm sac biological activity and remains insufficiently predicted by anatomical surveillance alone. We aimed to evaluate whether integration of circulating matrix metall...

Provenance and competence for CHIKV and DENV of Aedes albopictus populations

Aedes albopictus is one of the world’s most hazardous invasive species, increasingly implicated in the autochthonous transmission of Chikungunya (CHIKV) and Dengue (DENV) viruses in newly colonized areas. Since invading the Mediterranean Basin several in the early 1980s, recurren...

Health utilities in individuals with alpha-1 antitrypsin deficiency with and without COPD from the EARCO registry

Background Data on health utilities in Alpha-1 antitrypsin deficiency (AATD) are scarce. This study aimed to evaluate health-related quality of life (HRQoL) using the EQ-5D in a cohort of AATD Pi*ZZ individuals from the European AATD Research Collaboration (EARCO) registry and to...

Neurologic Stability During Tafamidis Treatment in Transthyretin Amyloidosis with a Mixed Phenotype: A Multicenter Real-World Study

Real-world evidence on the effect of tafamidis in mixed-phenotype transthyretin (TTR) amyloidosis (ATTR amyloidosis) is limited. This study assessed changes in neurologic and other measures in patients with mixed-phenotype ATTR amyloidosis treated with tafamidis free acid 61 mg f...

Development and Characterization of Pseudotype-based Microneutralization Assay to Assess Functionality of Anti-rabies Protein G Antibodies

Background Rabies virus (RABV) is a neurotropic zoonotic pathogen responsible for an estimated 60,000 human deaths annually. Despite widespread vaccination programs, rabies remains a substantial public health burden, particularly in regions with limited access to post-exposure pr...

Large-Scale Cerebellar-Cerebral Network Alterations Underlying Impaired Social Predictive Processing in Cerebellar Neurodegeneration

Abstract The cerebellum is a key node for detecting and adjusting social-prediction internal models. Yet social prediction has been scantly investigated in neurodegenerative cerebellar patients (CB). Thus, we examined CB social-prediction abilities and related cerebellar-cerebral...