University of Ottawa

Ethical and Methodological Features of Cluster Randomized Trials in Critical Care Settings: A Systematic Review

OBJECTIVES: Cluster randomized trials (CRTs) are useful for evaluating system-level interventions in critical care but raise complex ethical and methodological issues that are amplified in this setting. We aimed to describe ethical and methodological features of CRTs in critical...

Emerging Post‐CMOS Hardware Neurons for Brain‐Inspired Computing: Devices, Circuits, and System Integration

ABSTRACT The fundamental energy and latency limitations of the von Neumann architecture have necessitated a paradigm shift toward neuromorphic systems. This approach addresses the “memory wall” bottleneck by emulating the brain's event‐driven and massively parallel processing cap...

MIR192 upregulates GLP-1 receptor and rescues statin-induced impairment of insulin secretion

Abstract Background Statins are a commonly prescribed cholesterol-lowering drug class that can increase the risk of new-onset diabetes (NOD). The underlying molecular mechanisms have yet to be fully elucidated. We aimed to identify molecular factors associated with differential s...

Surgical Nurses’ Experience of Hallway Healthcare

Background Hallway healthcare refers to the provision of patient care in hospital hallways. Although traditionally associated with overcrowded emergency departments, it has increasingly extended into acute inpatient settings. Differences in the organization and delivery of care a...

Structural dynamics during the three-ion Coulomb explosion of highly charged CS2 in intense soft x-ray pulses

Using intense femtosecond soft x-ray pulses above the sulfur 2p edge produced by the Free-electron LASer in Hamburg (FLASH), we investigate the multiple ionization and fragmentation dynamics of CS2. We focus on the three-ion fragmentation pathways of CS2 polycations with total ch...

Frameworks to identify research gaps, frame research needs, and derive research priorities from evidence syntheses:a scoping review

Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certai...

ALY688 Protects Against Myocardial Ischemia‐Reperfusion Injury via Direct Effects and Rab8a‐Dependent Extracellular Vesicles

ABSTRACT Despite advances in percutaneous coronary intervention, ischemia‐reperfusion (IR) injury remains a major cause of morbidity and mortality. Adiponectin confers broad cardioprotective effects, motivating the development of adiponectin receptor agonists. Here, we investigat...

How precariously employed gay, bisexual, and queer immigrant and refugee men in Toronto make meaning of work, health, and wellbeing

Abstract Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people experience mental health and trauma outcomes as a result of systemic exclusion from the labour market in Canada, with less known about intersectional labour precarity for LGBTQ+ immigrants. How LGBTQ+ immigra...

LLM-Driven Cost-Effective Requirements Change Impact Analysis

Requirements are inherently subject to change throughout the software development lifecycle. Within the limited budget available to requirements engineers, manually identifying the impact of such changes on other requirements is error-prone and effort-intensive, especially in reg...

How Does Brief Mindfulness Training Influence Neurophysiology During Working Memory in Musicians With Music Performance Anxiety?

Musicians rely on working memory to perform but this can be impacted by performance anxiety. This exploratory study examined whether a mindfulness training program would show beneficial effects on working memory in musicians with music performance anxiety (MPA). Twenty musicians...

“You Don’t Belong in Hospital”: How Hospital-Based Dementia Stigma Shapes Health-Related Quality of Life

Health-related quality of life reflects individuals’ perceptions of how a health condition affects their physical, psychological, and social functioning. Amid increasing pressures on primary care systems, people living with dementia are presenting more frequently to hospital sett...

The power of adaptation: Multilingual localisation of extIPA for clinical phonetics and cross-linguistic speech assessment

The Extensions to the International Phonetic Alphabet (extIPA) support clinical transcription of atypical and disordered speech, but their chart metalanguage is primarily available in English. This article presents a feasibility study of multilingual extIPA localisation as clinic...

Does Order Matter? The Impact of Methodological Decisions in Survey Research Concurrently Examining Attachment to Mothers and Fathers

ABSTRACT While questionnaires are often validated in a context where participants respond to a questionnaire only once, it is common to complete a given questionnaire multiple times referring to different relationships in interpersonal relationship research. For instance, in atta...

Deprotonation and Alkylation of Weakly Acidic C(sp 3 )─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert ‐Butoxide

ABSTRACT The direct deprotonation of weakly acidic C(sp 3 )─H bonds remains a fundamental strategy for generating carbon nucleophiles, but typically requires strong bases, cryogenic conditions, and stepwise protocols. A general method enabling single‐step deprotonation and alkyla...

Deprotonation and Alkylation of Weakly Acidic C(sp 3 )─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert ‐Butoxide

ABSTRACT The direct deprotonation of weakly acidic C(sp 3 )─H bonds remains a fundamental strategy for generating carbon nucleophiles, but typically requires strong bases, cryogenic conditions, and stepwise protocols. A general method enabling single‐step deprotonation and alkyla...

Resilience Definitions and Theories: Implications for Post-Secondary Students

Literature in psychology is replete with countless definitions and theories of resilience, which may create confusion among scholars and practitioners. In addition to varying from one publication to another, these definitions and theories have also evolved over the years. A narra...

Recent progress in emerging therapeutics and evaluation of oculopharyngeal muscular dystrophy

PURPOSE OF REVIEW: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset, genetic, neuromuscular disorder causing progressive ptosis, dysphagia and proximal muscle weakness. This review highlights emerging therapeutic strategies and recent advances in understanding the clinic...

Resynchronisation of the Biological Clock Using Exposure to Low Oxygen Levels in Humans: An Exploratory Study

Exposure to reduced oxygen levels occurs in several real-world contexts, such as during air travel or altitude exposure, and emerging evidence suggests that hypoxia may interact with molecular pathways involved in circadian regulation. This exploratory study investigated the effe...

Stellate ganglion block for posttraumatic stress disorder in Canadian Armed Forces Veterans and Royal Canadian Mounted Police: A case series

Introduction: Current treatments for posttraumatic stress disorder (PTSD) have shortcomings and less success in military Veterans. A significant challenge for recovery from PTSD is overcoming persistent and often intractable sympathetic hyper-arousal. This treatment gap has promp...

The Arctic Winter Games: A subversive model of sporting event amid resonance blockers

This research draws on resonance theory to analyse how the Arctic Winter Games (AWG) mitigate features linked with professionalized sport events – dynamics that can act as resonance blockers – to sustain conditions more conducive to resonance. Utilizing a qualitative multimethod...