University of Ottawa

Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission

The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades, yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association between an elevated paternal Body Mass Index...

Eggshell Membrane in Gut Health: Processing-Dependent Redox, Barrier, Immune, and Microbiome Effects

Gut health is maintained through interactions among intestinal barrier integrity, microbial homeostasis, host-immune function, and redox balance. Eggshell membrane (ESM), a protein-rich poultry by-product, contains structural components and derived peptides with antioxidant and a...

Systematic review of clinical trials and cohort studies evaluating HIV post‐exposure prophylaxis (PEP) regimens to inform updated Canadian guidelines

Abstract Background We conducted a systematic review of clinical trials and cohort studies on HIV post‐exposure prophylaxis (PEP) regimens to inform updated 2025 Canadian guidelines. Methods We searched Medline and Embase (July 2017–June 2024) for studies reporting on: HIV acquis...

A standardized permafrost ground temperature collection for Canada 2025

Abstract. Ground temperature is an essential variable for monitoring the thermal state of permafrost, developing models, and conducting fundamental research. However, the usability of GT data in Canada is often hampered by inconsistent file formats, a lack of metadata standardiza...

Seasonal surface melt onset and firn freeze-up across the central Wrangell and St. Elias Mountains

Abstract. High-elevation alpine firn is increasingly influenced by surface melt and meltwater retention, yet the spatial extent and timing of these processes remain poorly quantified. Here we present spatially distributed estimates of seasonal surface melt onset and firn freeze-u...

Cardiovascular risk prediction models for women: A systematic review protocol

Purpose Cardiovascular disease remains a leading cause of morbidity and mortality in women. Cardiovascular risk prediction models are widely used to guide preventative management, although many do not incorporate female-specific risk factors. The aim of this review is to identify...

Screening for Early Endometriosis Detection (SEED): Co-development of a Symptom-Based Screening Measure for Canadian Young Adults in Primary Care

Background Many Canadians experience prolonged pain, uncertainty, and stigma before receiving an endometriosis diagnosis, with delays averaging 11 years from symptom onset. Endometriosis, defined by the presence of endometrial-like tissue outside the uterine cavity, impacts 10% o...

Use of Telestroke Prior to Endovascular Stroke Treatment in Canada: Results from the OPTIMISE Registry

BACKGROUND: Telestroke allows rapid assessment of acute stroke patients for intravenous thrombolysis and endovascular thrombectomy (EVT). While its safety and efficacy for thrombolysis are well established, evidence regarding EVT decision-making via telestroke is scarce. METHODS:...

Consented Universal Newborn Screening for Congenital Cytomegalovirus Infection Using Dried Blood Spot and Dried Saliva Spot Specimens: Implementation and Relative Programmatic Accuracy

The purpose of this research was to evaluate the implementation and relative diagnostic accuracy of dried blood spot (DBS) and dried saliva spot (DSS)-based newborn screening for congenital cytomegalovirus infection (cCMV). This prospective paired-sample pilot studied consecutive...

Clinical outcomes of primary anterior cruciate ligament reconstruction with concomitant lateral meniscal posterior root tear repair versus isolated anterior cruciate ligament reconstruction: a systematic review and meta-analysis

Introduction Lateral meniscal posterior root tears (LMPRTs) commonly occur with anterior cruciate ligament (ACL) injuries, but clinical outcomes after concomitant repair remain unclear. Aim This systematic review and meta-analysis compared postoperative outcomes after ACL reconst...

Bioaccumulation, food web transfer, and tissue distribution of polonium-210 and lead-210 in Canadian freshwater ecosystems

Understanding the bioaccumulation and trophic transfer of naturally occurring radionuclides is essential for assessing ecological risk in freshwater systems. This study provides a large-scale assessment of polonium-210 ( 210 Po) and lead-210 ( 210 Pb) bioaccumulation, trophic tra...

Nomadism of thought as a logic for inducing more open futurities in coaching inquiry

Since its beginnings, coaching inquiry has been guided by disciplinary influences that have, as this paper argues, largely confined its doings to a dogmatic image of thought severely delimiting what is deemed possible, productive, and effective. As an affirmative response counter...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

A helix-loop-helix gene orchestrates male fate in common carp

Fish show exceptional diversity in sex-determination mechanisms, making them a powerful system for studying how these pathways evolve. However, no definitive master sex-determining gene has yet been identified in Cyprinidae, a widely distributed and species-rich fish family. Here...

The human gut microbiome primes fever after vaccination

Fever is a common adverse reaction to vaccination, contributing to vaccine hesitancy and reduced uptake. To understand variation in fever risk, we longitudinally profiled fecal microbiota, oral temperature, and serological markers in 171 healthy adults receiving Severe acute resp...

Impacts of COVID-19 on well-being during deployment and the role of leadership

Introduction: The COVID-19 pandemic created new challenges, adding or compounding the effects of many existing stressors that military personnel face during deployment. While these stressors can negatively impact individual and organizational outcomes by worsening well-being and...

Exogenous Carbohydrate Metabolism Under Energy Deficit and Environmental Stress

Physiological stress of environmental exposure and energy deficit impairs the absorption, transport, and utilization of exogenous carbohydrate for fuel during exercise. Blunted exogenous carbohydrate oxidation may require alternative fueling strategies to optimize carbohydrate me...

Housing-based support models for individuals experiencing homelessness, substance use and mental health needs: a rapid review

Abstract Background Individuals experiencing homelessness and substance use and mental health needs face high rates of mortality. Stable housing is a critical determinant of health, yet the evidence on existing housingbased support models and their effectiveness for improving beh...

Anticancer Drugs and Cancer-Associated Thrombosis

The rapid development of novel cancer therapies has considerably improved the care of cancer patients and cancer-related survival; however, these therapies are associated with a broad range of adverse events that have become a major burden in this population. Alongside other canc...

Calcium Isotopic Composition in Reindeer ( Rangifer tarandus ) Bones and Tooth Enamel: A Scalable Tool to Quantify Nursing Frequency in Past and Modern Populations?

RATIONALE: Populations of North American caribou and Eurasian reindeer (Rangifer tarandus sspp.), essential for Arctic ecosystems and human communities, are experiencing unprecedented declines due to climate change and anthropogenic pressures. While understanding their historical...