University of Massachusetts Chan Medical School

Quantitative computed tomography improves prediction of survival across ILD subtypes

Background Quantitative computed tomography (CT) methods are recognized as valuable tools for risk stratification in fibrotic interstitial lung disease (ILD). Data-driven textural analysis (DTA) is one such approach that correlates with worse lung function and shorter survival in...

suPAR Identifies Treatment-Resistant Inflammatory Risk Beyond hs-CRP in Type 2 Diabetes With Coronary Artery Disease: An Ancillary Analysis of BARI 2D

OBJECTIVE To determine whether soluble urokinase plasminogen activator receptor (suPAR) is modified by randomized diabetes and revascularization strategies in patients with type 2 diabetes and coronary artery disease and whether combined suPAR and hs-CRP classification refines re...

Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy

Breast cancer stemness drives tumor progression and therapy resistance, yet the underlying mechanisms remain poorly understood. In this study, we observed that RBM38 expression gradually decreases during breast cancer progression in MMTV - PyMT transgenic mice. Using a model with...

The impact of structural variation on Alzheimer’s disease in the Alzheimer’s disease sequencing project

Structural variants (SV), genomic alterations spanning more than 50 base pairs, can significantly impact gene expression and protein function. However, their contribution to Alzheimer’s disease (AD) remains poorly understood. Leveraging a novel SV calling pipeline, we identified...

Opportunities for Pediatricians to Address Racism and Bias to Reduce Racial Disparities in Breastfeeding and the Use of Human Milk: Policy Statement

Pediatricians play an essential role in breastfeeding care and are uniquely positioned to help reduce racial disparities in breastfeeding. Evidence-based solutions include partnerships between pediatricians and community health workers, implementation of culturally centered hospi...

JNK and p53 cause human and mouse β cell death during excessive unfolded protein response

Endoplasmic reticulum (ER) stress contributes to β cell death in both Type 1 and Type 2 diabetes (T1D and T2D). However, the molecular mechanisms driving β cell death during ER stress remain insufficiently defined, limiting development of protective therapies. GRP78, an ER chaper...

β1- and β2-adrenergic receptor mediated spontaneous contractions and ryanodine receptor channel opening in human failing heart

Abstract In heart failure, β-adrenergic receptor (β-AR)-Gsα-cAMP-protein kinase A (PKA) signalling predisposes to delayed-afterdepolarisation-mediated arrhythmias. Phosphodiesterases (PDEs) hydrolyse cAMP, and PDE3 restrains β 1 -AR, β 2 -AR-mediated inotropic responses in failin...

Differential genomic architecture of a ligand-receptor pair in humans and commonly used model organisms

The neuropeptide signaling pathway is vital for the physiology and behavior of multicellular organisms. This pathway is mediated by ligand-receptor binding, wherein neuropeptides (NPs) are often released from neurons, while their receptors (NPRs) are ubiquitously expressed in bot...

Bridging theory and practice in medical education: evaluating a faculty development masterclass using a commitment-to-change framework in a resource-variable setting

Despite advances in medical education, translating educational theory into routine teaching practice remains challenging. Faculty development programs often demonstrate high participant satisfaction but limited evidence of behavior change. The Commitment-to-Change (CtC) framework...