University of Massachusetts Chan Medical School

Systematic Characterization of Thermal Stability Assay Parameters and Application in Discovery of Peptide–Protein Interactions

Abstract Thermal proteome profiling (TPP) and its higher-throughput derivative, the proteome integral solubility alteration (PISA) assay, measure changes in protein thermal stability upon ligand binding or other perturbations and have been widely adopted in drug discovery and bio...

Assessing Value of Behavioral Interventions: Designing Cost-Effectiveness Analyses for Food-Is-Medicine Interventions

Food-is-Medicine (FIM) interventions, including medically tailored meals, medically tailored groceries, and produce prescriptions, represent a promising approach to prevent, manage, and treat diet-related diseases. As the evidence base for FIM interventions expands through large-...

Medicaid ACO Implementation and Pediatric Asthma Care Equity

OBJECTIVES: Poorly controlled asthma disproportionately impacts children from lower-income and racially or ethnically minority groups. We examined whether Massachusetts Medicaid Accountable Care Organization (ACO) implementation was associated with improved pediatric asthma care...

Mobile Cardiac Rehabilitation for Older Adults With Ischemic Heart Disease: A 12‐Month Follow‐Up on Hospital Readmissions in the RESILIENT Trial

Kaplan-Meier analysis of time to first all-cause readmission over 12 months among older adults with ischemic heart disease randomized to 3 months of mobile health cardiac rehabilitation (mHealth-CR) or usual care. There was no significant difference in time to first readmission b...

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

Detection of Single-Stranded DNA Gaps Reveals a Functional Biomarker of Therapeutic Response

Single-stranded DNA (ssDNA) gaps represent an underappreciated vulnerability that directly shapes therapeutic response in BRCA-deficient models. Current clinical biomarkers remain anchored to the double-strand break (DSB) centric model of homologous recombination deficiency (HRD)...

Clinical Characteristics and Outcomes of Melanoma Among Latin American Adolescents and Young Adults Compared to Middle-Aged and Elderly Population: A Cohort Analysis Over 10 Years

Introduction: Outcomes among the Hispanic population are rarely explored in adolescents and young adults (AYAs). We aimed to compare sociodemographic, clinical, and survival outcomes of Latin American AYAs (≤39 years) with middle-aged (40–59 years) and older (≥60 years) patients...

Neuroimmune Phenotyping as the Next Frontier in Chronic Pain Medicine for Musculoskeletal Back Pain

Chronic low back pain encompasses heterogeneous mechanical, neuropathic, nociplastic, and myofascial presentations that may reflect distinct neuroimmune mechanisms. We synthesized evidence linking these phenotypes to measurable biological features and clinically relevant treatmen...

In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

Abstract Cryogenic electron microscopy (cryo-EM) made impressive progress in resolving cellular macromolecules and their detailed interactions. Single-particle cryo-EM traditionally relies on purified macromolecules and lacks the complexity of cellular environments, whereas in si...

Enhancing Bone Marrow Lesion Segmentation Through Dual-Channel Deep Neural Networks and Test-Time Augmentation

Bone marrow lesion (BML) volume is an essential biomarker for understanding knee osteoarthritis (KOA). However, automatic BML segmentation remains challenging due to the irregular shapes and indistinct boundaries of these lesions in knee magnetic resonance images (MRI). To improv...

Modeling uncertainty in performance validity testing with Bayesian logistic regression

Objective: The aggregation of multiple performance validity tests (PVTs) into a summary validity determination is an established challenge in neuropsychology. The standard dichotomous accumulation approach relies upon binary recoding of continuous PVT scores and yields ambiguous...

Artificial Intelligence in Counseling and Counseling Psychology: A Counselor-Led Framework for Ethical Practice & Training

As generative artificial intelligence (AI) tools like ChatGPT become increasingly accessible, counseling psychologists are exploring their potential use in clinical practice, often without clear guidance or ethical frameworks. This paper presents a counselor-led model for integra...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

Emergency department diagnosis and management of acetaminophen or salicylate toxicity.

Acetaminophen and salicylate are among the most widely used nonprescription analgesics and are common causes of toxic medication overdose. Diagnostic and management approaches differ depending on whether toxicity results from a single acute ingestion or chronic supratherapeutic u...

FAK regulates leptin-induced angiogenesis and vasculogenic mimicry in breast cancer

Abstract Leptin, an adipokine primarily secreted by adipose tissue, has been implicated in tumor progression by regulating angiogenesis. Leptin also plays a key role in tumor vascularization by promoting vasculogenic mimicry (VM). During tumor progression, leptin activates severa...

Food protein-induced allergic proctocolitis: an early step on the atopic march

PURPOSE OF REVIEW: Food protein-induced allergic proctocolitis (FPIAP) has traditionally been considered a benign, non-immunoglobulin E (IgE)-mediated condition of infancy without long-term consequences. This review examines evidence challenging this framework and discusses FPIAP...

Development and Reliability Testing of the Sinonasal Assessment of Reepithelialization, a Novel Wound Healing Scale to Assess Postoperative Healing

ABSTRACT Background Sinus and skull base surgery create areas of demucosalized bone and cartilage in the sinonasal cavity, yet no standardized system exists to describe the progressive healing of these wounds. The goal of this study was to develop the novel Sinonasal Assessment o...

“I Just Need Guidance Through This Maze I’m Going Through”: Addressing Unmet Basic and Mental Health Needs to Facilitate Engagement in HIV Prevention Services in the Context of Stimulant Use

There is a global syndemic of HIV, mental health challenges, substance use, and structural barriers. Critical to local HIV prevention efforts is understanding this syndemic in the context of rising stimulant use to inform intervention development. Adhering to the EPIS model, we c...

Implementation of a pilot online educational program to identify paramagnetic rim lesions

Background: Paramagnetic rim lesions are a highly specific magnetic resonance imaging biomarker for multiple sclerosis now incorporated into the 2024 McDonald Criteria. However, paramagnetic rim lesion identification remains underutilized in clinical practice. This study evaluate...

Trends in Medicines Discontinuation and Implications for Access in Brazil (2014–2024)

ABSTRACT Purpose The World Health Organization ( WHO ) began recognizing drug shortages as a global issue in 2014, impacting health systems and patient care. Shortages arise from supply chain disruptions, production issues, and mismatches between supply and demand, aggravated by...