University of Maryland, Baltimore

Modeling the heterogeneity of cognitive dysfunction in Parkinson’s disease using partially ordered set models

Abstract Traditional binary classifications of Parkinson’s disease (PD) cognitive dysfunction fail to capture its inherent heterogeneity. This study introduces the Partially Ordered Set (POSET) model, a Bayesian framework, to analyze cognitive heterogeneity using Parkinson’s Prec...

Immobilized Neuroglobin Scavenges Carbon Monoxide From Circulating Carboxyhemoglobin

Carbon monoxide (CO) poisoning is responsible for around 50,000 emergency department visits per year in the United States alone. Currently, there is no available antidote for CO poisoning. We have previously developed an antidotal therapy based on an engineered hemeprotein, human...

Multimodal folate receptor-targeted liposomes enable photo-chemo-antibiotic synergy for peritoneal cancer therapy

The complex and heterogeneous nature of cancer presents significant challenges to effective treatment. Because no single therapy can overcome this complex challenge, rational combination strategies that concurrently target tumor survival pathways and engage non-overlapping mechan...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Structural Vulnerability and the Pandemic: Widening Gaps in Nursing Home Antipsychotic Prescribing

To assess whether national reductions in antipsychotic prescribing in U.S. nursing homes were shared equitably or masked widening gaps between top and bottom performers, we examined distributional trends across facilities from 2013 to 2023 using national facility-level data (CMS...

Adjuvant Systemic Hypothermia During Mechanical Thrombectomy (ReCCLAIM II): A Multicenter, Randomized, Controlled Trial

BACKGROUND: Hypothermia reduces ischemic injury in preclinical stroke models, yet translation into the clinical setting remains challenging. We aimed to assess the feasibility of inducing adjuvant systemic hypothermia among patients with large-vessel occlusion stroke during mecha...

Retrohepatic inferior vena cava injuries: surgical anatomy and operative maneuvers the trauma surgeon needs to know

Injuries of the retrohepatic inferior vena cava are among the most lethal encountered in abdominal trauma. They are anatomically unforgiving: the retrohepatic cava is a short venous segment embedded within the liver, tethered by numerous fragile tributaries that drain downstream...

PET imaging enables direct evaluation of ferroptosis in HCC synergistically induced by anti-PD-L1 and Olaparib

Abstract The efficacy of PET image-guided immune checkpoint inhibitor-based therapy in hepatocellular carcinoma (HCC) management is limited by the lack of direct monitoring of therapeutic response. A key challenge is the mismatch between the therapeutic pathway and the imaging ta...

Clathrin recruitment and assembly of phosphorylated B cell receptor is impaired in human diffuse large B cell lymphoma

The B cell receptor (BCR) drives the differentiation of naive B cells into activated plasma cells that produce antibodies. The BCR consists of a plasma membrane-bound surface immunoglobulin (sIg) that binds antigens, and two coreceptor subunits CD79A and CD79B. The intracellular...

A systematic review of hydrocephalus and psychiatric comorbidities in children and adults with spina bifida

Spina bifida in children and adults is accompanied by substantial psychiatric comorbidity. Hydrocephalus is a common complication of spina bifida and is associated with functional and cognitive deficits, but the role of hydrocephalus in psychiatric comorbidities of spina bifida i...

Isolation of diverse nontuberculous mycobacteria from Hawai’i feral pigs and identification of Mycobacterium abscessus subsp. bolletii

Abstract Background Nontuberculous mycobacteria (NTM) are environmentally acquired opportunistic pathogens that can cause recalcitrant pulmonary disease, particularly in susceptible individuals. Hawai’i has a high incidence of NTM infections, meriting a better understanding of th...

Metrology, Standards, and Mission: Synopsis of the 2026 Annual Meeting of the Council on Ionizing Radiation Measurements and Standards (CIRMS)

The Council on Ionizing Radiation Measurements and Standards (CIRMS) is an independent, non-profit council composed of experts from academia, government, and industry across all areas of ionizing radiation science and technology, providing leadership, focus, and coordinated actio...

Longitudinal Surgical Modeling of Early Glioblastoma Recurrence Reveals Emergence of Margin-Associated Neural Programs

Glioblastoma (GBM) is a lethal, treatment-resistant brain cancer characterized by diffuse brain invasion, complex neuron-glioma signaling, and cellular, molecular, and spatial heterogeneity. Surgery is the current mainstay of treatment, aimed at maximizing tumor cytoreduction, de...

Investigating the thermal degradation of multi-board decking materials ignited by firebrand piles

Background Firebrand piles are a major contributor to structural losses during wildland–urban interface fires. Among potential recipient fuels, decking materials exhibit ignition susceptibility that is strongly dependent on material type. However, experiments on representative mu...

Management of Type 2 Diabetes, 2026. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the consensus statement on the management of type 2 diabetes in nonpregnant adults, published since 2006 and last updated in 2022. The target audience is the multid...

Young Woman With Shortness of Breath

A 22-year-old woman presented to the emergency department with sudden onset of shortness of breath that began 12 hours before presentation, associated with positional chest pain. She denied any trauma or infectious symptoms. Her only significant past medical history included seve...

Modeling decision dynamics disentangles working memory, cognitive control and reinforcement learning and reveals clinical differences

Various neurocognitive processes contribute to reinforcement learning (RL) and decision making, requiring careful task designs and computational modeling to disentangle them. People rely on capacity-limited working memory (WM) to rapidly and flexibly adapt behavior during learnin...

Winning and losing experiences differentially alter learning performance and forebrain protein expression in mangrove rivulus killifish, Kryptolebias marmoratus

Contest outcomes alter future social behavior, but whether and how a single win or loss influences non-social learning-task performance and triggers rapid forebrain molecular responses remains unclear. The self-fertilizing mangrove rivulus killifish, Kryptolebias marmoratus , off...

A modified Delphi study of expert consensus on mental health service access and digital strategies for adolescents and young people living with HIV in Zambia

Adolescents and young people living with human immunodeficiency virus (HIV), hereafter AYPLHIV, experience depression, anxiety, behavioural difficulties, and psychosocial distress that may undermine antiretroviral therapy (ART) adherence and long-term HIV outcomes. In Zambia, men...

Synergistic effects of cerebrovascular reactivity and gray matter volume on executive function in aging

Background Age-related impairments in cerebrovascular reactivity (CVR) and gray matter volume (GMV) both contribute to cognitive decline, yet their regional interplay and joint impact on cognition remain unclear. Objective To investigate how CVR and GMV are coupled and interact r...