University of Manitoba

Implications of proteome allocation constraints for understanding interbacterial antagonism

Bacteria live in dense communities where competition influences the composition and, therefore, the function of these communities. Beyond competing for resources, bacteria engage in antagonism by deploying a range of molecular weapon systems to inhibit and kill other bacteria. In...

Optimizing a culture-enriched hybrid metagenomics pipeline to assess the AMR footprint of livestock manure in anaerobic digestate

ABSTRACT The role of environmental samples from livestock production systems, including manure and anaerobic digestate, as reservoirs of antimicrobial resistance genes (ARGs) is likely underestimated because conventional metagenomic approaches can overlook low-abundance ARGs and...

Simplicial resolutions of the quadratic power of monomial ideals

Given any monomial ideal $ I $ minimally generated by $ q $ monomials, we define a simplicial complex $\mathbb{M}_q^2$ that supports a resolution of $ I^2 $. We also define a subcomplex $\mathbb{M}^2(I)$, which depends on the monomial generators of $I$ and also supports the resol...

Rhinosinusitis in Adults Receiving Tumor Necrosis Factor Alpha Inhibitors and Anti‐CD20 Therapy: A Scoping Review

ABSTRACT Introduction Immunomodulatory therapies, including tumor necrosis factor alpha (TNF‐α) inhibitors and anti‐CD20 agents, are often used for autoimmune, inflammatory, and neoplastic disorders. While infection risk is well recognized, their association with rhinosinusitis r...

Three-million-year pulse: Pace and processes of Late Jurassic magmatism in the Sierra Nevada arc

Continental arcs commonly experience brief, high-flux magmatic pulses, and the Late Jurassic Sierra Nevada arc records one such event as a compositionally diverse magmatic system that includes highly silicic plutonic, hypabyssal, and volcanic rocks, associated cumulate gabbros, a...

Utility of Face2Gene’s DeepGestalt and D-Score applications in paediatric neurodevelopmental disorders in South Africa

Abstract Face2Gene is a clinical tool that leverages facial features to aid genetic diagnosis. The DeepGestalt application suggests potential diagnoses based on facial similarity, while the D-Score evaluates likelihood of an individual having dysmorphic features suggestive of a p...

Are individual differences in “unconstrained thought” meaningfully distinct from spontaneous and deliberate mind wandering?

Here, we developed the Unconstrained Thought Questionnaire (UTQ) to assess the dynamics of unconstrained thought (or ‘mind wandering’), as described by the Dynamic Framework. We aimed to determine whether the UTQ’s measure of unconstrained thought provides unique explanatory powe...

Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation

Interactions among molecular recognition systems, neuronal activity, and glial regulation transform early neuronal connectivity into precise functional circuits during brain development. The cerebellum is a powerful model for studying these mechanisms due to its stereotyped and a...

Sustainability Certification Adoption in Small and Medium Enterprises' Food Supply Chains: Using a Complexity Approach to Build up Foundations

ABSTRACT Adopting certifications in food supply chains (FSCs) is a common practice for sustainable management, including among small and medium enterprises (SMEs). This study investigates how SMEs in FSCs navigate the complexities of certification adoption for sustainable supply...

Privacy-preserving federated reinforcement learning for BESS coordination in distribution networks with voltage regulation

The increasing integration of distributed energy resources (DERs) in distribution networks, particularly battery energy storage systems (BESSs), enables energy trading and operational cost reduction but also introduces challenges for coordinated energy management. Effective coord...

AI-designed prion-capping proteins provide evidence that prion fibril ends are replication-competent surfaces that contribute to prion seeding activity and infectivity

ABSTRACT End-elongation of amyloid fibrils is a prevailing theory to explain prion replication, but direct experimental evidence for this phenomenon is limited by the lack of research tools. To serve as molecular probes for prion fibril termini, here, we designed protein binders...

A Tutorial on Gaussian Process Learning-based Model Predictive Control

This tutorial provides an accessible and implementation-oriented introduction to Gaussian process learning-based model predictive control (GP-MPC), which combines probabilistic residual modeling with receding-horizon control. Its central tutorial contribution is a detailed, step-...

Dr. Tsai et al reply

We appreciate the interest of Drs. Wang and Qu¹ in our work,² and their call for more family-friendly metrics to help convey meaningful quality of life improvements in juvenile idiopathic arthritis ( JIA). After considering the different ideas suggested in t...

INTERNATIONAL ENVIRONMENTAL AGREEMENTS AND AFRICA'S COMMITMENT TO SUSTAINABILITY

Our Mother Earth is currently facing a lot of environmental concerns. The current environmental challenges represent a considerable measure of danger to the well-being of people and creatures. The environmental problems like global warming, acid rain, air pollution, urban sprawl,...

Patient-physician sex concordance and real-world disparities in cancer treatment practices and outcomes in medical oncology

The impact of sex inequities in healthcare may be magnified in medical oncology, where patients and physicians often navigate life-limiting illnesses and intensive treatments. We examined the associations among patient-physician sex concordance, treatment practices, and cancer ou...

Newcastle disease virus is a safe and immunogenic respiratory-delivered vaccine against SARS-CoV-2 in a ferret model

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused close to 800 million infections and over 7 million deaths worldwide. In addition to its impact on human health, the virus has shown cross-species transmission, including spillover into mustelids such as m...

Emergency department providers’ perspectives on patients’ use of cannabis: therapeutic potential, risks, and prescribing experience

Abstract Background Cannabis legalization in Canada has increased both therapeutic and recreational use. Emergency department (ED) providers encounter patients using cannabis recreationally, to self-manage symptoms, or under medical authorization, often without a clear distinctio...

Virtual Health Interventions to Improve Breastfeeding: A Systematic Review

CONTEXT Use of virtual health interventions has increased rapidly, with growing evidence evaluating virtual breastfeeding support. However, the effectiveness of different types of virtual breastfeeding interventions remains unclear. OBJECTIVE To examine the effects of various typ...

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change

Abstract Background Identifying individuals at risk for future weight gain is challenging, partly because associations with traditional clinical risk factors may be biased by confounding and reverse causation. Polygenic risk scores (PRS) provide a stable, lifelong measure of gene...

Rapid, low-cost, and portable molecular detection of HIV-1 subtype B and HCV 1a directly from blood

Accessible molecular diagnostics for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain constrained by the cost and infrastructure requirements of existing molecular point-of-care platforms. In this study, we describe a portable, proof-of-concept molecular...