University of Manitoba

A photogrammetry phenomic approach to quantifying canopy architecture traits in spring wheat

Canopy architecture refers to the arrangement of plant organs, leaves and shoots within a canopy and is an important plant trait which contributes to yield. High-throughput phenotyping has gained attention because of its high efficiency, quantitative and non-destructive method of...

Diagnostic evolution of carbonic anhydrase 3 (CA3) in Amyotrophic Lateral Sclerosis (ALS): an emerging prognostic biomarker

Introduction Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease traditionally viewed as a motor neuron disorder in which muscle atrophy occurs secondary to neuronal loss. However, recent clinical proteomic advances have highlighted carbonic anhydrase 3 (CA3)...

Jaw Claudication Progressing to Scalp and Tongue Necrosis in Giant Cell Arteritis

Giant cell arteritis (GCA) is a primary large vessel vasculitis affecting individuals over 50 years of age, characterized by granulomatous inflammation of the aorta and its major branches.1 Temporal artery biopsy (TAB) remains the diagnostic gold standard, and high-dose glucocort...

Interferon-λ inhibits immunopathology and boosts T cell–mediated immunity in a mouse model of mucosal viral infection

Interferon lambda (IFN-λ) has emerged as a critical inducer of immune regulation in addition to its mucosal antiviral properties. However, the cellular and molecular mechanisms that govern its dual role during viral infections remain unclear. Here, we discovered that mucosal deli...

Use of Telestroke Prior to Endovascular Stroke Treatment in Canada: Results from the OPTIMISE Registry

BACKGROUND: Telestroke allows rapid assessment of acute stroke patients for intravenous thrombolysis and endovascular thrombectomy (EVT). While its safety and efficacy for thrombolysis are well established, evidence regarding EVT decision-making via telestroke is scarce. METHODS:...

Evidence for cortisol production in a shark

Corticosteroids are essential regulators of numerous physiological functions in vertebrates, including energy balance, immune responses, osmotic balance and metabolism. The terminal corticosteroids are highly conserved across jawed vertebrates, where cortisol or corticosterone me...

Differentiated time-frequency envelope kurtosis-gram guided adaptive variational multi-harmonic mode extraction for fault diagnosis of offshore wind turbine slewing bearings

Early fault characteristics of offshore wind turbine slewing bearings are weak and easily masked by noise, making accurate extraction difficult. To address this problem, a differentiated Time-Frequency Envelope Kurtosis-gram (TFEKgram) guided Adaptive Variational Multi-Harmonic M...

Self-Esteem as a Shared Resource Beyond Romantic Relationships: An Extension Into Friendships and Parental Relationships

Self-esteem is an important factor in understanding relationship quality, for both the individual and their romantic partner. Yet, most research has focused on solely romantic relationships, neglecting other close relationships that are at least equally important for understandin...

ATF6 shapes PERK and IRE1 signaling dynamics during ER stress

Abstract The Unfolded Protein Response (UPR) is a conserved network of signaling pathways controlled by the Endoplasmic Reticulum (ER) anchored stress sensors IRE1, PERK and ATF6. The UPR’s primary function is to help cells manage and resolve ER stress. Compared with the well-cha...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Shared patterns of human milk composition link mammary gland function to infant growth

The mammary gland produces nutrient-rich human milk (HM), yet how mammary functional state shapes HM composition and infant outcomes remains poorly understood. We used HM multi-omics - metabolomics, proteomics, micronutrients, macronutrients, and HM oligosaccharides - across 1,54...

Flow‐Critical Graphs

ABSTRACT Lovász et al. proved that every six‐edge‐connected graph has a nowhere‐zero three‐flow. In fact, they proved a more technical statement, which says that there exists a nowhere‐zero three‐flow that extends the flow prescribed on the incident edges of a single vertex with...

Evaluating packaged ice safety using culture-based and metagenomic methods

Ice can serve as a vector for microbial contamination, presenting potential risks to public health. This study aimed to evaluate the microbial quality and safety of commercially available ice in Manitoba as well as to characterize the microbiome of ice cubes and assess the presen...

The human gut microbiome primes fever after vaccination

Fever is a common adverse reaction to vaccination, contributing to vaccine hesitancy and reduced uptake. To understand variation in fever risk, we longitudinally profiled fecal microbiota, oral temperature, and serological markers in 171 healthy adults receiving Severe acute resp...

Genomic prediction of antimicrobial resistance in priority healthcare pathogens using Staramr

ABSTRACT Treatment of healthcare-associated infections is becoming increasingly challenging due to rising antimicrobial resistance (AMR). As clinical microbiology and public health continue to transition toward whole-genome sequencing (WGS) for outbreak detection, diagnostics, an...

To Greater Twist: A Kinetically Biased π‐Radical Cascade

π-Radical cascades of open-shell graphene fragments-exemplified by phenalenyl and related systems-are emerging as a versatile synthetic tool for constructing complex polycyclic aromatic frameworks. While previous investigations showed that the reaction outcome can be reduced to a...

Emergency obstetric and newborn care availability, utilization and referral capabilities in Zambia using a national facility census

Abstract Introduction Improving maternal and newborn health remains a global priority. Despite an increase in the number of health facilities providing childbirth services, not all can perform basic or comprehensive emergency obstetric and newborn care (EmONC) to avert maternal a...

Lingxi: Repository-Level Issue Resolution Framework Enhanced by Procedural Knowledge Guided Scaling

Driven by the advancements of Large Language Models (LLMs), LLM-powered agents are making significant improvements in software engineering tasks, yet struggle with complex, repository-level issue resolution. Existing agent-based methods have two key limitations. First, they lack...

Deformation, metamorphism, and time: a multi-method approach to mid-low temperature geochronology in Precambrian cratons

Abstract This study examines the microstructural, petrological, and geochemical processes that disrupt date relationships within biotite and apatite. We combine SEM-EBSD, cold/SEM-cathodoluminescence, EPMA and LA-ICP-MS geochemical mapping, with in situ multi-system geochronology...

44. A Benchmark Study of Feeding and Management Practices, Feed Utilization, and Adoption of Growth-enhancing Technologies by the Canadian Feedlot Industry.

Abstract The Canadian feedlot industry is exceptionally diverse, in both operational practices and feeding management. Previous Canadian feedlot industry surveys lacked detailed information on feed ingredient usage, feeding management, and the use of growth and health enhancing t...