University of Manitoba

Privacy-preserving federated reinforcement learning for BESS coordination in distribution networks with voltage regulation

The increasing integration of distributed energy resources (DERs) in distribution networks, particularly battery energy storage systems (BESSs), enables energy trading and operational cost reduction but also introduces challenges for coordinated energy management. Effective coord...

AI-designed prion-capping proteins provide evidence that prion fibril ends are replication-competent surfaces that contribute to prion seeding activity and infectivity

ABSTRACT End-elongation of amyloid fibrils is a prevailing theory to explain prion replication, but direct experimental evidence for this phenomenon is limited by the lack of research tools. To serve as molecular probes for prion fibril termini, here, we designed protein binders...

A Tutorial on Gaussian Process Learning-based Model Predictive Control

This tutorial provides an accessible and implementation-oriented introduction to Gaussian process learning-based model predictive control (GP-MPC), which combines probabilistic residual modeling with receding-horizon control. Its central tutorial contribution is a detailed, step-...

Dr. Tsai et al reply

We appreciate the interest of Drs. Wang and Qu¹ in our work,² and their call for more family-friendly metrics to help convey meaningful quality of life improvements in juvenile idiopathic arthritis ( JIA). After considering the different ideas suggested in t...

INTERNATIONAL ENVIRONMENTAL AGREEMENTS AND AFRICA'S COMMITMENT TO SUSTAINABILITY

Our Mother Earth is currently facing a lot of environmental concerns. The current environmental challenges represent a considerable measure of danger to the well-being of people and creatures. The environmental problems like global warming, acid rain, air pollution, urban sprawl,...

Emergency department providers’ perspectives on patients’ use of cannabis: therapeutic potential, risks, and prescribing experience

Abstract Background Cannabis legalization in Canada has increased both therapeutic and recreational use. Emergency department (ED) providers encounter patients using cannabis recreationally, to self-manage symptoms, or under medical authorization, often without a clear distinctio...

Patient-physician sex concordance and real-world disparities in cancer treatment practices and outcomes in medical oncology

The impact of sex inequities in healthcare may be magnified in medical oncology, where patients and physicians often navigate life-limiting illnesses and intensive treatments. We examined the associations among patient-physician sex concordance, treatment practices, and cancer ou...

Newcastle disease virus is a safe and immunogenic respiratory-delivered vaccine against SARS-CoV-2 in a ferret model

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused close to 800 million infections and over 7 million deaths worldwide. In addition to its impact on human health, the virus has shown cross-species transmission, including spillover into mustelids such as m...

Virtual Health Interventions to Improve Breastfeeding: A Systematic Review

CONTEXT Use of virtual health interventions has increased rapidly, with growing evidence evaluating virtual breastfeeding support. However, the effectiveness of different types of virtual breastfeeding interventions remains unclear. OBJECTIVE To examine the effects of various typ...

Rapid, low-cost, and portable molecular detection of HIV-1 subtype B and HCV 1a directly from blood

Accessible molecular diagnostics for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain constrained by the cost and infrastructure requirements of existing molecular point-of-care platforms. In this study, we describe a portable, proof-of-concept molecular...

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change

Abstract Background Identifying individuals at risk for future weight gain is challenging, partly because associations with traditional clinical risk factors may be biased by confounding and reverse causation. Polygenic risk scores (PRS) provide a stable, lifelong measure of gene...

CFD-Based Simulation and Optimization of Summer Environmental Conditions in Laying Hen Houses

To address uneven temperature and relative humidity distributions, localized heat accumulation, and insufficient air velocity in an enclosed stacked-cage laying hen house, a three-dimensional computational fluid dynamics (CFD) model of the laying hen house was developed using fie...

Clinical Joint Tenderness in First-Nations First-Degree Relatives of Rheumatoid Arthritis Patients: Examining Factors Associated with Functional Disability and Progression to RA

Objectives Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting synovial joints. Prior to the clinical onset of arthritis, autoantibodies and non-specific joint symptoms often appear in the absence of joint swelling. We previously found that functional disability...