University of Liverpool

Socioeconomic conditions and children’s out-of-home care in high-income countries: a systematic review and meta-analysis

Background Socioeconomic inequalities in children’s out-of-home care (OHC) are a major public health problem. Though widely documented, no review has systematically synthesised evidence across high-income countries. We aimed to compare the risk of OHC for children experiencing di...

Cost-effectiveness of screening for developmental dysplasia of the hip in children born in England and Wales

Aims: The aim of this study was to evaluate the cost-effectiveness of screening programmes for identifying developmental hip dysplasia (DDH) in children born in England and Wales. Methods: The costs and quality-adjusted life-years (QALYs) associated with DDH screening programmes...

Drug stock-outs in HIV, tuberculosis, and malaria programs: a systematic review

Background Stock-outs of antiretroviral, anti-tuberculosis, and anti-malarial medicines remain a major challenge in low- and middle-income countries, affecting both health systems and patient outcomes. This systematic review aimed to synthesize evidence on the causes, consequence...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...

RAS inhibition limits oncogenic signaling and tumorigenesis in neuroblastoma regardless of RAS mutational status

Abstract Neuroblastoma (NBL) is a rare and aggressive pediatric malignancy with a 5-year survival rate of 40–50% for patients diagnosed with high-risk disease. NBLs arise in the sympathetic nervous system and causes 11% of all pediatric cancer deaths. MYCN amplification or overex...

Pricing Trust: How Privacy Shapes the Demand for Central Bank Digital Currencies

Abstract Debates over central bank digital currencies (CBDCs) often emphasise efficiency, innovation and anti-money laundering compliance, while neglecting privacy as a determinant of their viability. This article argues that privacy is not merely a rights-based concern but also...