University of Liverpool

Non-pollen palynomorphs (NPPs) and their role in reconstructing the paleoclimate of the Seki-Eceler Höyük during the Holocene in southwestern Türkiye

This study investigates non-pollen palynomorph (NPP) assemblages from the 4.7 m long JARK014-4 sediment core to reconstruct Holocene palaeoenvironmental changes at Seki-Eceler Höyük in southwestern Türkiye. During the early Holocene, the abundance of NPPs related to freshwater, i...

The Impact of Diabetes on Risk of Revision Following Anterior Cruciate Ligament Reconstruction: A Real-World Data Study

Given the increasing prevalence of diabetes mellitus (DM), understanding its impact on anterior cruciate ligament reconstruction (ACLR) revision risk is important for clinical decision-making and patient counselling. This study evaluated whether DM is associated with an increased...

Status and Challenges of Multisectoral Antimicrobial Resistance (AMR) Surveillance in Ethiopia: Leveraging TADAS.net as a Digital Tool

Abstract Antimicrobial resistance (AMR) is a major One Health challenge requiring coordinated surveillance across human, animal, and environmental sectors. Ethiopia’s Antimicrobial Resistance Prevention and Containment Strategic Plan (2021–2025) recognized this need and prioritiz...

Optimized Hemoglobin Depletion Improves Clinical Proteomics from Dried Blood Spots

Abstract Equitable access to large sample cohorts for robust, high-throughput proteomics for biomarker discovery is a major barrier to widescale clinical implementation. Dried blood spots (DBS) offer a minimally invasive alternative to venous blood draws, enabling at-home microsa...

Continuous versus intermittent, non-invasive monitoring of vital signs in hospitalised, ward based adult patients: A systematic review and narrative synthesis

Background: Intermittent monitoring (IM) of vital signs remains the standard of care for hospitalised ward patients, yet this approach creates gaps during which patient deterioration may go unrecognised. Wearable wireless devices capable of continuously measuring physiological pa...

Dialkylation of Vinyl Arenes under Cobalt Catalysis

Abstract Herein, a directing group and ligand-free cobalt-catalyzed alkene dialkylation with various alkyl halides and alkylzinc pivalates is reported. This method is distinguished by its broad scope, synthetic simplicity, and excellent regio- and chemoselectivities, thus providi...

Guidance to inform communication with bereaved relatives about patient participation in emergency and critical care trials before death

Background Research in emergency and critical care is essential to improve outcomes for critically ill patients, yet many patients lack capacity to provide informed consent at the point of enrolment. Alternative consent models, including research without prior consent, are theref...

Influence of bone-specific material properties on finite element modelling of the skull

Abstract The material properties of bone in the skull are known to be heterogeneous and orthotropic, although datasets detailing these properties on a species level are limited. Therefore, computational modelling frequently uses homogeneous, isotropic material properties to analy...

Introducing a New Dimension of Individual Differences in Existential Psychology: Development and Initial Validation of the Existential Reflection Scale

Measuring individual differences in existential psychology has traditionally been centred around two key themes: (a) the ways in which individuals seek or attain meaning and purpose in life and (b) the extent of their anxiety related to existence and mortality. We introduce a new...

Association of Long-Term Residentially Assigned Speciated Atmospheric Mercury Emission Flux with All-Cause and Cause-Specific Mortality

Abstract Mercury (Hg) is a persistent global pollutant, but population evidence on residentially assigned species-specific atmospheric Hg emission flux and mortality is limited. We analyzed UK Biobank cohorts for all-cause/other-cause (N = 322,666), cardiovascular disease (N = 34...

Left Atrial Appendage Closure Versus Oral Anticoagulation for Prevention of Stroke or Systemic Embolism in Patients With Atrial Fibrillation: An Updated Meta‐Analysis of 7004 Patients Across Six Randomized Trials

ABSTRACT Introduction Left atrial appendage closure (LAAC) is an emerging alternative for stroke prevention in patients with atrial fibrillation (AF) who are unsuitable for long‐term oral anticoagulants (OACs). However, its efficacy and safety relative to OACs remain uncertain. M...

Distinct drivers control trace metal distributions through the Atlantic Ocean

Trace metals (TMs) including iron, manganese, cobalt, nickel, copper, zinc, cadmium, and lead have important biogeochemical roles in the ocean. However, the controlling factors of TM distributions have not yet been quantified and investigated on an ocean scale. Here we take a hol...

Chronic alanine aminotransferase elevation in people with HIV : Time trends over 22 years and genetic predisposition

Abstract Introduction Chronic elevation of alanine aminotransferase (cALT) is common in people with HIV. Published reports on cALT prevalence time trends have not been uniform. It is unknown whether genetic background is associated with cALT in people with HIV. Methods cALT was d...

Is primary metatarsalgia associated with a longer 2nd metatarsal? A comparison of metatarsal lengths in individuals with and without metatarsalgia

Background Metatarsalgia is a generic term used to describe localised forefoot pain around the metatarsals. Primary metatarsalgia is thought to be caused by excessive loading over one or multiple metatarsal heads resulting in localised inflammation and painful callosities. An ide...

Why don't all birds lay early? Causes and consequences of breeding timing for a long‐lived migratory seabird

The relationship between earlier laying and higher breeding success is well-established in avian species. However, a wide distribution of breeding timings is often maintained within a population, and the causes and consequences of this variation require further exploration, parti...

Plasma Glutamine and Glutamate in Relation to Clinical Outcomes After Ischemic Stroke: A Multicenter Prospective Study

Background Glutamine (Gln) and glutamate (Glu) have been suggested to play a pivotal role in neuronal homeostasis and metabolic regulation, showing potential as prognostic biomarkers for stroke. This study aimed to evaluate the associations of plasma Gln, Glu, and glutamine‐to‐gl...

Two millennia of Caspian Sea level change and Hyrcanian forest dynamics: A multi-proxy record from the Anzali Lagoon, northern Iran

A multi-proxy study of a 5-m-long sediment core from the Anzali Lagoon (southwest Caspian coasts) was conducted to reconstruct Caspian Sea level fluctuations and concurrent vegetation history in the Hyrcanian forests over the past two millennia. The record reveals several major t...

Removing Tuition Dependency From Dental Education: Consensus Recommendations on Student Debt, Sustainability, and Pathway Reform

BACKGROUND: The current financing model for US dental education is increasingly misaligned with the goals of sustainability, equity, and workforce design. Tuition has risen substantially over time, educational debt among dental graduates remains high, and evidence suggests that p...

Survival, stigma and structural barriers: a qualitative study exploring the oral health experiences of women attending sex work support services in Liverpool

Aims Globally, sex workers experience significant oral health inequalities, including higher levels of dental decay, tooth loss, and trauma. Sex workers face intersecting challenges including homelessness, addiction, and stigma. In the UK, no qualitative research has explored the...

No Time to Dye: Portable Surface-Enhanced Raman Scattering for On-Site Detection of Sudan IV Dye in Palm Oil

Abstract The widespread use of Sudan IV dye as an adulterant in palm oil poses significant public health risks. This nonfood-grade dye, linked to carcinogenic effects, has prompted a pressing need for efficient, rapid, and reliable field-portable detection methods. This study inv...