University of Liverpool

45 Predicting sites of tumour progression in the invasive margin of glioblastomas (PRaM-GBM Study): a multicentre imaging study

Abstract Introduction Despite advances in surgery and radiotherapy, glioblastoma patients often experience progression within a year, adjacent to the resection cavity. Conventional imaging techniques are not sensitive enough to detect invasive tumour, leaving occult tumour undete...

Virus-like particle display of consensus α-neurotoxins does not enhance neutralising antibody responses against elapid venoms

Snakebite envenoming is a neglected tropical disease, with neurotoxic elapid venoms in particular posing a major therapeutic challenge due to the rapid action and inter-species diversity of α-neurotoxins. Consensus toxin approaches have emerged as a promising strategy for generat...

LDL-C–stratified residual lipoprotein(a) and inflammatory risk after acute myocardial infarction among patients with prior statin use

Abstract Background Patients can experience acute myocardial infarction (AMI) despite documented prior statin exposure, indicating persistent residual cardiovascular risk. The prognostic relevance of lipoprotein(a) [Lp(a)] and residual inflammation in this setting remains unclear...

Has the situation changed? Spatio-temporal analysis of green spaces change and socioeconomic status in Liverpool, UK

Although the benefits of green space to residents’ wellbeing are well documented, more evidence is needed to track socio-spatial inequalities. This paper applied exploratory spatial data analysis and multiscale geographically weighted regression (MGWR) to analyse the relationship...

Resolving the Abstract–Concrete Paradox in the Angular Gyrus:A Multimethod Investigation

Abstract Despite its well-established role in memory-guided cognition, whether and how the angular gyrus (AG) contributes to semantic processing remains unresolved. Connectomic work links the AG to abstract mentation, yet neuroimaging studies paradoxically show greater AG engagem...

Transcending the Space‐Bandwidth and Lighting Trade‐Offs: A Programmable Self‐Mixing Interferometry Imager for Cross‐Scale Surface Inspection

ABSTRACT Industrial optical inspection is fundamentally limited by the trade‐off between spatial bandwidth (field‐of‐view vs. resolution) and vulnerability to ambient lighting. This work addresses these challenges by proposing a programmable imager based on amplitude‐modulated la...

Implementing telemedicine under polycrisis: a mixed-methods case study from Myanmar using the RE-AIM framework

Myanmar’s March 2025 7.7-magnitude earthquake intersected with conflict, governance breakdown, and economic collapse, leaving 12.9 million people needing health assistance, yet evidence on how telemedicine functions under such polycrisis conditions remains limited. We conducted a...

Spliceosome gene mutations synergize with anthracyclines to amplify atrial fibrillation risk in hematologic malignancies: a multicenter cohort study with discovery and validation

Abstract Background Atrial fibrillation (AF) is a life‑threatening complication in patients with hematologic malignancies, yet personalized risk stratification remains challenging. Spliceosome gene mutations are key drivers of these malignancies, but their specific role in AF pat...

Risk of protein intake deficiency during treatment with GLP-1 and GIP/GLP-1 receptor agonists: considerations for secondary sarcopenia

Sarcopenia, characterized by the age-related decline in muscle mass and strength, increases the risk of falls, fractures, disability, and mortality. Type 2 diabetes and obesity frequently coexist with sarcopenia, contributing to the growing clinical challenge of sarcopenic obesit...

A lattice Boltzmann method for floating oscillating water column WECs

In this study, a hierarchical multi-fidelity modelling framework, combining the lattice Boltzmann method (LBM) and potential-flow approach, is developed to investigate the two-dimensional floating oscillating water column (OWC) wave energy converters (WEC). The framework is built...

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

Making hidden biases visible in population location data from mobile phones

Abstract Traditional sources of population data, such as censuses and surveys, are costly, infrequent and often unavailable in crisis-affected regions. Mobile phone data (MPD) offer near-real-time, high-resolution insights into population distribution, but their utility is underm...

Acceptability of advanced Controlled Human Infection Models: The case of a pneumococcal challenge in people living with HIV and mycobacterial challenge with Bacillus Calmette Guerin in Malawi

Abstract Background Controlled Human Infection Models (CHIM) in which volunteers are experimentally exposed to pathogens are used to study pathogenesis and down select among treatment and vaccine candidates. Scientifically, CHIM studies are best conducted among at-risk population...

Shared and Distinct T-Cell Receptor Characteristics of CD4+ and CD8+ Drug-Specific T-Cells In Vitro Generated from Healthy Donors and Hypersensitive Patients

Abstract The initiation of T-cell-mediated drug hypersensitivity reaction requires the formation of a human leukocyte antigen (HLA)-peptide-drug-T-cell receptor (TCR) complex. While specific interactions between HLA molecules and drug antigens are well-defined, the characteristic...

When indemnity insurance fails: Parametric coverage under binding budget and risk constraints

Abstract In high‐risk environments, traditional indemnity insurance is often unaffordable or ineffective, despite its well‐known optimality under expected utility. We compare excess‐of‐loss indemnity insurance with parametric insurance within a common mean‐variance framework, all...

Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI): an international study

Juvenile localised scleroderma (jLS) is a rare disease which impacts negatively on health-related quality of life (HRQoL). We aimed to undertake the cross-cultural adaptation and validation of a novel disease-specific HRQoL measure, the Localised Scleroderma Quality of Life Instr...

Insights Into Public Attitudes for Effective First Responder Communication During a Simulated Mass Casualty Incident

ABSTRACT Effective public communication during Mass Casualty Incidents (MCI) is essential for safeguarding life, maintaining order, and sustaining trust in emergency responders. Yet, high‐pressure, information‐scarce environments make this communication challenging. This mixed‐me...

Role of Life’s Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants

Background: Night shift work is linked to higher risks of cardiovascular disease (CVD) and mortality, but mechanisms remain unclear. Lifestyle, captured by the American Heart Association's Life's Essential 8 (LE8), may act as a modifiable mediator. We aimed to examine the associa...

Does plastic waste present an infection hazard? Current evidence, surveillance challenges and research priorities

Abstract Unmanaged plastic waste is widespread in settings with limited waste collection, yet its contribution to infectious disease risk remains poorly understood. In this review, we synthesise current evidence on the human health implications of plastic waste, with a specific f...