University of Lisbon

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...

First record of xanthochromism in Nasua (Carnivora, Procyonidae) with notes on anomalously colored coatis

Abstract Coatis ( Nasua ) are diurnal, gregarious mesocarnivores widely distributed across the Americas. Chromatic disorders are rarely documented in this genus. Here, we report the first record of xanthochromism in Nasua , based on two individuals of N. nasua observed in Tijuca...

Exploiting Multicomponent Reactions to Drive the Development of Novel Antitubercular Agents: An Overview

Tuberculosis (TB) remains a global epidemic, and Mycobacterium tuberculosis (Mtb), its etiological agent, continues to be the deadliest single infectious agent worldwide. Our inability to eradicate TB is strongly related to Mtb's ability to alternate between an active and latent...

A compilation of global bio-optical in situ data for ocean-colour satellite applications – version four

Abstract. A global in situ dataset for validation of satellite products from the ESA Ocean Colour Climate Change Initiative (OC-CCI) is presented. This version of the compilation, with data starting in 1996, extends to 2025, which is important for the validation of recent algorit...

Slowly rotating condensate dark stars beyond the mean-field approximation

Abstract We investigate rotational properties and universal relations of slowly rotating Bose–Einstein condensate dark stars in the context of General Relativity, both at the mean-field level and when the leading beyond-mean-field Lee–Huang–Yang correction is retained self-consis...

The reproductive matrix: regulating transmasculine pregnancy and parenthood

This article develops the concept of the reproductive matrix as a material-discursive regime that regulates who can reproduce, through which bodies, and under what conditions of parental recognition. Extending Butler’s account of the heterosexual matrix, and drawing on Barad’s ma...

Revisiting the “Care Penalty” in the Portuguese Labor Market: Uncovering (Gender) Pay Differentials in Long‐Term Care

ABSTRACT Focusing on the distinctive characteristics of the highly gendered long‐term care (LTC) sector, in this study, we analyze wages and earnings within caring sectors through an integrated theoretical approach that includes theories of ageism, compensating wage differentials...

Enhancement of liquid cooling in microchannel heat sinks: numerical and experimental assessment of progressive geometric optimisation

The increasing power density of modern electronic devices and high-power energy systems requires liquid-cooling solutions capable of dissipating high heat fluxes while maintaining acceptable pressure losses and temperature non-uniformity. Microchannel heat sinks (MCHSs) are promi...

Between Individual Belief and National Context: Relative Positioning and Expectations of Collective Climate Action in Europe

Expectations regarding collective climate action are multidimensional and should be understood in relation to the social contexts in which they are embedded. This study examines whether these expectations are associated with the country-level average belief in the anthropogenic o...

Navigating Uncharted Waters: Steering the Course and Confronting Challenges of Brain Metastases in EGFR-Mutant Non-Small Cell Lung Cancer

Brain metastases represent a major clinical challenge in the management of non-small-cell lung cancer, particularly in patients with epidermal growth factor receptor mutations, constituting a leading cause of morbidity and mortality. In recent years, significant advancements have...

Hybrid flax/carbon bonded composite patches for strengthening of steel plates: layup and adhesive effect

Adhesive bonding of Fiber-Reinforced Polymer (FRP) patches is increasingly used to strengthen steel structures. Considering that carbon FRP (CFRP) and epoxy adhesives are the primary materials in industrial applications, this study explores the feasibility of hybridizing CFRPs wi...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Navigating regulatory scenarios for accelerating drug repurposing in rare diseases: a multi-stakeholder perspective on the challenges and opportunities

<title>Abstract</title> Background: The lack of treatments for patients with a rare disease calls for innovative approaches in drug development. A potential solution to accelerate therapy development is to find new therapeutic uses for existing drugs, i.e. drug repurposing. One w...

Potential of Mobile LiDAR Sensors in Hiking Trail Management

The LiDAR sensor embedded in recent iPhone Pro devices offers new opportunities for rapid, low-cost, and spatially detailed assessment of outdoor recreational infrastructure. Framed within mobile sensing and IoT-based environmental monitoring, this proof-of-concept case study eva...

Effectiveness and Safety of a Self-Management Program for Substance Addiction Consequences: A Pilot Clinical Trial

Background: Harmful substance use affects millions of people, producing health and social consequences that require both professional support and effective self-management. This study piloted a self-management program targeting the consequences of substance addiction in adults en...

Genomic analysis and clinical characteristics of a seasonal upsurge of Streptococcus pyogenes emm12

Abstract Purpose Streptococcus pyogenes cause invasive infections with variable incidence over time. In 2023, an increase in invasive S. pyogenes infections caused by emm- types 1 and 12 was reported globally. In Southern Sweden an increase in S. pyogenes emm 12 severe infections...

Long-Lived Interfacial Charge Separation in PyrenylimidazolylPhthalocyanine@Transition Metal Dichalchogenide Heterostructures

Abstract Pyrenylimidazolyl-functionalized free-base phthalocyanines (H2Pc) and their zinc complexes (ZnPc) constitute multifunctional building blocks for realizing heterostructures with liquid phase exfoliated transition-metal dichalcogenides (LPE-TMDs). Here, we report the synth...

A multiple correspondence analysis of the voluntary turnover in the Portuguese Armed Forces

Purpose This study aims to identify the primary reasons for voluntary turnover in the Portuguese Armed Forces by developing distinct leaver profiles. Design/methodology/approach Using secondary data from 835 exit records, a mixed-method approach combining content analysis and mul...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Analysing Lost Highway as a Non-deterministic Narrative Structure: Initiating Déjà Vu-like Recognition to Establish Non-causal Linkage

This article examines how repetition produces déjà vu-like recognition in non-deterministic narrative cinema. Focusing on David Lynch’s Lost Highway (1997), it argues that the film’s repetitions do not lead to conventional repetition–resolution, but instead organise an entangled...