University of Lisbon

Stability and Bifurcation of a Multi-Trait Eco-Evolutionary Logistic-Type Model

We extend a two-dimensional discrete-time eco-evolutionary logistic model to the case of finitely many quantitative traits. The original planar model couples population density to a single mean trait under stabilizing selection; the extension retains this mechanism while allowing...

Codonopsis tangshen Attenuates Age-Related Pulmonary Fibrosis through Senescence and Gut–Lung Axis Modulation

Background: Cellular senescence is a critical driver of chronic inflammation, tissue remodeling, and progressive fibrosis during the aging process. Codonopsis tangshen Oliv. is a widely used medicinal and edible homologous plant in traditional Chinese medicine; however, its pharm...

New Δ246p53 isoform responds to DNA damage to enhance p53 family functions in cellular senescence

Abstract p53 is, without a doubt, one of the most powerful genes in our genome, as it makes growth vs arrest, repair vs replacement, catabolism vs anabolism, life vs death decisions in the cell. An alteration or malfunction in p53 may lead to cancer, degeneration or premature age...

Resilient train formation control for ASVs under intermittent communication environment via actor–critic reinforcement learning

To address the train formation task of autonomous surface vehicles (ASVs) operating under intermittent communication environment, this paper investigates the problem of resilient formation robust control for ASVs. First, a resilient distributed leader predictor (RDLP) is designed...

Neurologic Stability During Tafamidis Treatment in Transthyretin Amyloidosis with a Mixed Phenotype: A Multicenter Real-World Study

Real-world evidence on the effect of tafamidis in mixed-phenotype transthyretin (TTR) amyloidosis (ATTR amyloidosis) is limited. This study assessed changes in neurologic and other measures in patients with mixed-phenotype ATTR amyloidosis treated with tafamidis free acid 61 mg f...

Wing-assisted electric catamaran designed for zero-emission operation across the Aeolian Islands

This study examines an innovative rigid wing sail incorporated into an electric catamaran with zero-emission potential in the Aeolian Islands. The catamaran has an overall length of 5 m, a breadth of 2.5 m, a draft of 0.20 m, and a displacement of 500 kg. The analysis quantifies...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Breeding bird data from the Côa River Basin (Portugal): twenty-six years of change in a Mediterranean landscape in transition

Breeding bird data from the Côa River Basin (Portugal): twenty-six years of change in a Mediterranean landscape in transition This data package brings together standardized breeding-bird transect data collected in the Côa River Basin, north-eastern Portugal, over twenty-six years...

Comment to García-Vadillo et al. (2026) on the first Large Flake Acheulean in Europe at Revilleja de Valparaíso site

This paper critiques the proposal by García-Vadillo et al. (2026) regarding the site of Revilleja de Valparaíso (Burgos, Spain), which suggests an MIS 17 (∼700 ka) chronology for the earliest Large Flake Acheulean (LFA) in the Iberian Peninsula. The study in question exhibits poo...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Pedagogical Interventions That Support Self-Regulated Learning in Secondary School Students: A Systematic Literature Review

Self-regulation of learning (SRL) is a key skill for secondary school students, placing them as active and conscious agents of their own learning. It enables learners to plan, monitor, and evaluate their progress, fostering autonomy and responsibility. Teachers play a crucial rol...

Host cell traversal by Plasmodium parasites drives sterilizing T cell-mediated immunity following immunization

Abstract The development of a vaccine capable of conferring sterile protection against Plasmodium , the causative agent of malaria, is a major priority for global eradication efforts. Whole-organism vaccines using liver-infective sporozoites provide high levels of sterile protect...

Ultrasonic Guided Wave Localization and Classification of Damage-like Perturbations in a CFRP Plate Using a PZT Network

Ultrasonic guided waves acquired using permanently bonded piezoelectric transducers enable large-area monitoring of composite structures. For practical structural health monitoring; however, both the location and the condition of a structural change are critical. This paper prese...

Chaperone-inspired nanobodies enable pathway-selective control of Tau self-assembly

Abstract Selective control of pathogenic protein self-assembly remains a major challenge for intrinsically disordered amyloid-forming proteins such as Tau. Here we show that nanobodies originally raised against the chaperone S100B unexpectedly cross-react with Tau as potential pa...

Opening Hours and Consumer Behavior: Evidence From GPS Data and Deregulation

ABSTRACT In 2019, North Dakota repealed its Sunday closing law, which had required most non‐grocery stores to close between midnight and noon. Using this policy change and consumer GPS data, we study the impact of opening hours on shopping behavior and welfare. We compare visits...

Stem-cell modeling of cerebellar dysfunction of Angelman syndrome

Angelman syndrome is a severe neurodevelopmental disorder caused by loss of function of the maternal allele of the neuron-specific imprinted gene UBE3A. Although Angelman syndrome presents with developmental delay, ataxia, epilepsy, and speech impairment, the contribution of spec...

Critical minerals and investment frameworks: Formalizing the bankability framework

Private investment in critical mineral projects is arguably not scaling at the pace required to meet projected demand, despite adequate reserves and abundant long-duration capital. The binding constraint is bankability. A recent policy framework matches mineral market structure,...

The Contribution of DAS to the Routine Monitoring of Seismicity in Oceanic Islands: The Case for Faial (Azores)

Distributed acoustic sensing (DAS) deployed on submarine telecom cables is bound to revolutionize the earthquake monitoring routine currently performed by seismic network operators, particularly in domains where most seismic activity originates offshore. In this work, we analyze...

(Mis)Classification for in‐Control/Out‐of‐Control Decisions in Statistical Quality Control: A Case Study

ABSTRACT This case study examines decision‐making processes within a potato chip production line, where controlling the frying oil temperature is vital for maintaining product quality. The process is considered in‐control (InC) when the mean frying oil temperature is 180°C, with...

Zinc dimethacrylate-modified epoxy coating for corrosion protection and self-healing

Corrosion-related asset losses and safety risks are increasing the need for smarter protective coating strategies. In this work, zinc dimethacrylate (ZDMA) was incorporated into epoxy coatings for enhanced corrosion protection for carbon steel. The successful integration of ZDMA...