University of Leicester

Addressing evidence gaps in haemodialysis care: a critical review of clinical trials, technological innovations, and implementation priorities

Kidney failure treated with maintenance haemodialysis (HD) carries high risks of premature mortality, hospitalisation and impaired quality of life, yet important evidence gaps persist across routine HD care. The Dialysis Research Innovation Network, part of the UK Kidney Research...

Harnessing the Joys and Mitigating the Risks of Doing Co-Research: Reflections on a Study With Survivors of Sexual Violence

Background This article is by lived experience co-researchers and an academic research team. Co-research involves those with lived experience of a topic under investigation. It is an increasingly popular participatory, beneficial form of co-production that improves the integrity...

Inside the ward round: Experiences and perspectives of autistic patients and mental health hospital staff

Autistic individuals experience disproportionately high rates of mental health conditions and hospitalisation, yet research about their perspectives within inpatient decision-making structures, such as the ward round, is limited. We address this gap by exploring how autistic adul...

Gas absorption of soft X-rays strongly impacts the redshift distribution of dark Fast X-ray Transients

Abstract The progenitors of many Fast X-ray Transients (FXTs) and those of γ-ray bursts (GRBs) are strongly linked. Given that ”dark” GRBs are typically found to be events suffering from enhanced extinction in the host galaxy, we investigate the nature of ”dark” FXTs. However, un...

Rare events algorithm study of extreme double jet summers and their connection with heatwaves over the Northern Hemisphere

Abstract Several large scale circulation patterns have been identified in relation to extreme Northern Hemisphere summer heatwaves. Three main ones are a double jet over Eurasia, a positive phase of the summer northern annular mode, and a quasi-wave-3 geopotential height anomaly....

Turning the tide: digital resource orchestration for SME turnaround

Purpose Declining small and medium-sized enterprises (SMEs) face survival-threatening vulnerability, yet limited research explains how digital resources are orchestrated for recovery. Drawing on resource orchestration theory (ROT), this study examines how SMEs reconfigure digital...

Examining the mental health support needs of NHS staff exposed to patient pregnancy and neonatal loss: A qualitative study

Background Pregnancy and neonatal loss, including miscarriage, stillbirth, termination for fetal abnormality, and neonatal death, affects a substantial proportion of pregnancies in the UK. Although the impact on patients is well documented, less attention has been paid to the exp...

Synergistic Effect of Ambient Ozone, Relative Humidity, and Temperature on Epidemic Patterns of Influenza: A Hypothesis and Its Verification

The mechanisms underlying seasonal patterns in influenza epidemics have long been an enigma. Our laboratory study revealed that ambient ozone significantly inactivates airborne influenza viruses synergistically with higher relative humidity and temperature. This led us to hypothe...

Hydrological drivers of hydrogen cyanide wildfire emissions from Indonesian peat fires during the 2015, 2019, and 2023 El Niño events

Indonesian peatlands store vast amounts of carbon that are highly vulnerable to fire during El Niño-driven droughts. When ignited, peat releases large quantities of greenhouse gases and other species with significant environmental impacts, including hydrogen cyanide (HCN), a sens...

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

Satellite DNAs in Drosophila koepferae (repleta group) reveal patterns of origin, chromosomal organization, transcription, and turnover in the buzzatii cluster

Abstract Satellite DNAs (satDNAs) are non-coding tandem repeats that can comprise more than 20% of eukaryotic genomes. They contribute to structural and regulatory processes in the genome and often evolve rapidly, shaping early stages of genetic differentiation between population...

Pain alleviation in diabetic neuropathy using hybrid closed loop insulin pumps (PAINLESS) – A randomised crossover trial protocol

Introduction Painful diabetic neuropathy (PDN) is a common complication of diabetes that leads to significant co-morbidity. Emerging evidence suggests glycaemic variability may be linked to fluctuations in pain intensity. Hybrid closed loop (HCL) systems reduce glycaemic variabil...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli

Abstract Urinary tract infection (UTI) remains a major global health burden, with frequent recurrences and rising antimicrobial resistance compromising treatment efficacy. Conventional susceptibility assays often fail to predict clinical outcomes, highlighting the need for more p...

LiteFDNet: A Lightweight Deep Network for Cardiotocography-Based Fetal Distress Detection

This retrospective single-center study developed and evaluated LiteFDNet, a lightweight deep neural network for intrapartum fetal distress detection from cardiotocography (CTG). All eligible deliveries from April 2014 to December 2024 were included under IRB approval (LGECH-2023-...

Hypertrophic cardiomyopathy: a genome-wide association meta-analysis and polygenic risk score

ABSTRACT Background Hypertrophic cardiomyopathy (HCM) is a heritable trait with marked variability in expression and outcomes. Our aims were to discover new genetic loci associated with HCM and to test the effect of a new polygenic risk score (PRS) on incidence, phenotype and out...

Exploration of the relevancy of nutritional knowledge and self‐perceived nutrition competency of the UK Optometric Workforce

Abstract Purpose This study investigated the self‐perceived competence, knowledge, confidence and attitudes of the UK optometric workforce with regard to nutritional advice for patients. Methods A validated questionnaire (NUTrition COMPetence) was used to survey the optometric wo...

Barriers and Enablers to Nurses Routinely Screening for Oropharyngeal Dysphagia in Hospitalised Older Adults: An Evidence Synthesis of Qualitative Studies

ABSTRACT Aim To identify and describe the barriers and enablers to nurses routinely screening for dysphagia in hospital and map these to domains in the Theoretical Domains Framework. Design Systematic review with meta‐ethnography. Data Base Sources CINAHL, Embase, PubMed, Scopus,...

Phase Transitions for Interacting Particle Systems on Random Graphs

Abstract. In this paper, we study weakly interacting diffusion processes on random graphs. Our main focus is on the properties of the mean-field limit and, in particular, on the nonuniqueness and bifurcation structure of stationary states. By extending classical bifurcation analy...

Global HRM and Transnational Networks: Unpacking the Micro‐Behavioral Process Supporting Global HRM Integration Using a Quantitative Multi‐Source, Multi‐Level Design

ABSTRACT Whether and why social processes support global HRM integration is an overlooked, yet increasingly relevant performance question in decentralized transnational work environments. Using social capital theory, we conceptualize the social dynamic and behaviors influencing g...