University of Kentucky

The CNNM-binding interface drives PRL-3-dependent tumor progression in de novo cancer models

Phosphatase of regenerating liver 3 (PRL-3) is a cancer-associated protein linked to tumor progression, metastasis, and poor patient outcomes, but the mechanism underlying its oncogenic activity remains unresolved. PRL-3 functions both as a phosphatase and as a binding partner of...

The Limited Lifetime of Self-Gravitating Accretion Disks in Galactic Centers

Globally self-gravitating accretion disks in active galactic nuclei (AGN) have been frequently discussed in the literature, but never observed. A few dozen megamasering accretion disks in AGN have been detected, which display a clear Keplerian rotation on scales of 0.1–1 pc, allo...

Ambivalent Multiculturalism in Organizations: The Case of SafeHarbor International

Multiculturalism remains a desirable, yet challenging, dream to realize in the modern workplace. Field research was conducted to investigate multicultural dynamics at a multinational, multilingual organization, headquartered in Japan. This ethnographic case study documents sensem...

Nothing new under the sun: Agentic AI and the automated, connected catalog

The emergence of agentic AI is an important technology trend, and its implications for technical services librarianship have the potential to be profound. Agentic AI is introduced and distinguished from generative AI through its capacity to pursue goals, coordinate specialized ag...

The effects of royal jelly consumption on glycemia indices, lipid profile, and blood pressure in patients with acute ischemic stroke: a randomized, triple-blind trial

Abstract Aims The effects of royal jelly (RJ) on cardiometabolic risk factors in patients with acute ischemic stroke have not been previously reported from this trial. Therefore, we conducted a secondary analysis to investigate the effects of RJ consumption on glycemic indices, l...

Student perceptions of written, AI and coached reflection

The authors declare no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

Diagnosis and management of acute hyperkalaemia

Abstract Hyperkalaemia is a common and potentially life threatening electrolyte abnormality because of its association with malignant cardiac arrhythmias and sudden cardiac arrest. This condition is frequently encountered across acute and chronic care settings and disproportionat...

Hemp-derived cannabinoid use among young adults in Lexington, Kentucky in 2024

Abstract Introduction : The availability and use of hemp-derived cannabinoids (HDCs), such as delta-8-THC and CBD, have increased rapidly due to changes in US cannabis policy and their federally legal status. The health effects of HDCs remain largely unknown. Limited data exists...

Near-Adjacent HeavyLanthanide Separation and SensingUsing Dimerizing Lanmodulins

Abstract Protein-based recovery, detection, and separation of rare earth elements (REs) have accelerated since the discovery of the lanmodulin (LanM) proteins. While exceptional at total RE recovery, prior proteins, like most ligands, exhibited limited ability to differentiate RE...

Global Prevalence and Specificity of Red Blood Cell Antibodies in Blood Donors: A Systematic Review and Meta-Analysis

Background: Red blood cell (RBC) antibody screening in blood donors is a key component of transfusion safety. However, reported prevalence and antibody specificities vary widely across studies, and a consolidated global estimate remains limited. This study aimed to quantify the p...

The Architecture of Consolidation: Nests of Corporate Control in the Agrochemical Network

ABSTRACT Research on agricultural consolidation tends to equate corporate control with the dominance of a few large firms. We take an alternative approach that examines control through the explosive growth of legally distinct firms that fragment accountability. Using a new global...

The Impact of Covid-19 on Various Offerings Within a Worksite Wellness Program

Worksite wellness programs are popular employer offerings as of the last few decades. The COVID-19 pandemic caused major shifts in behavior since these programs were implemented. The purpose of this study was to understand how the COVID-19 pandemic affected participation in a wor...

Myoglianin coordinates hormonal and nutrient signaling to control metamorphosis and tissue growth in the fall armyworm

The transition from larval to pupal stage in holometabolous insects is a critical developmental decision regulated by hormonal and nutritional cues. The studies reported here revealed a central role for the TGF-β ligand Myoglianin (Myo) in integrating these signals in a major lep...

Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice

Abstract Megakaryocytes (MKs) are large, polyploid cells that contribute to bone marrow homeostasis through the secretion of cytokines such as transforming growth factor β1 (TGFβ1). During neoplastic transformation, immature MKs accumulate in the bone marrow where they induce fib...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Enrolling middle school staff in the CSTOP Now! cRCT to prevent child sex trafficking: preliminary effectiveness of recruitment strategies

Child sex trafficking (CST) has significant, long-term health consequences for children and their families. Given higher risk of CST for middle school-aged children, the significant time spent by students in schools under staff supervision, and the opportunity to provide CST prev...

Smash powers and traces on parametrized spectra: an application of rigidity

Abstract The bicategory of parametrized spectra has a remarkably rich structure. We can take traces in this bicategory, giving classical invariants that count fixed points. We can also take $$C_n$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>C</mm...

Infective Endocarditis Hospitalizations in Kentucky, 2008-2018: Spatial and Temporal Trends

Introduction: Infective endocarditis (IE) hospitalization rates have increased significantly in the last decade, primarily due to the opioid epidemic. In 2016, Kentucky (KY) ranked among the top ten states for opioid-related overdose deaths, but limited data exist on IE trends in...

Evaluating the Feasibility and Preliminary Effectiveness of a Tailored Diabetes Education Program for Rural Residents

Introduction: Diabetes is a top ten Rural Healthy People 2030 priority for health improvement among rural Americans. Socioeconomic, environmental, geographic and political barriers contribute to the type 2 diabetes (T2D) prevalence and its disparate impact in rural communities. H...

Spin Purity andSpin Mixing in Lanthanide–CyclooctatetraeneComplexes: SO-MCQDPT2 and Axial-Field Analysis

Abstract Despite strong relativistic effects in organolanthanide systems, the origin and extent of spin-state mixing within the resulting electronic manifolds remain not fully resolved. In this article, we present a systematic analysis of Ln(COT) (Ln = Ce, Pr, Nd; COT = cycloocta...