University of Hong Kong

HER2-low metastatic breast cancers: clinic-pathological characteristics, metastatic sites, and survival impact on biomarker discordance

Abstract Trastuzumab Deruxtecan has shown promising results in patients with HER2-low and -ultralow (UL) metastatic breast cancers, attracting extensive research on these tumors. While most studies focus on primary tumors, there is limited data on metastatic disease. Here, we aim...

Understanding the pathways for scaling rural innovations: Insights from 34 rural revitalization cases in Asia

Despite a growing number of innovative rural revitalization practices in Asia, the patterns and mechanisms through which such innovations are scaled have not been thoroughly explored. This study distinguishes three forms of rural innovation scaling, namely expansion, replication,...

Automated Multimodal Correlative Registration for Organelle-Specific Elemental and Isotopic Imaging

Abstract Mapping the subcellular partitioning of therapeutics is important for understanding their trafficking, mechanisms of action, and off-target effects. NanoSIMS provides chemical images of labeled therapeutics, but assigning these signals to cellular structures requires cor...

Gap-tuned exceptional skin effect in non-Hermitian flat bands

Flat-band states in Hermitian systems exhibit compact localization in the bulk due to geometric or symmetry constraints, while non-Hermitian skin effects drive state accumulation at boundaries via asymmetric lattice hoppings. Despite extensive efforts devoted to studying these tw...

The parent bodies of Ryugu and Ivuna formed before those of other carbonaceous chondrites

Most carbonaceous chondrite (CC) meteorites contain abundant chondrules, millimeter-scale spherical inclusions of previously molten material. Ivuna-type carbonaceous chondrites (CIs) do not contain chondrules, nor do samples of the carbonaceous asteroid Ryugu. CIs and Ryugu share...

Executive functions in Cantonese-English bilingual autistic and neurotypical children: The role of first and second language exposure across different communicative contexts

This study investigated the impact of first language (L1) and second language (L2) exposure on working memory and inhibitory control in 6- to 10-year-old Cantonese-English bilingual autistic children (N = 36, mean age = 8;05, SD = 1.02) and bilingual neurotypical children (N = 40...

Vanadium‐Vacancy‐Induced Atomically Polarized Heterojunctions for Synergistic Bioenergetic Pathogen Disruption and Peripheral Nerve Regeneration

ABSTRACT Drug‐resistant bacterial infections and persistent oxidative stress severely impair nerve endings in burn wounds, presenting a formidable clinical challenge. Current treatment modalities generally fail to achieve simultaneous pathogenic eradication and neuro‐regeneration...

Generative AI in Clinical Dental Education: Balancing Innovation With Academic Integrity Through Teacher‐Centric Implementation

Generative artificial intelligence (AI) is transforming dental education, presenting simultaneous opportunities and challenges to academic integrity, assessment validity and clinical competency development. Faculty perspectives, the most critical yet understudied determinant of s...

Unraveling the Importance of Carboxyl Groups in Photochemically Excited Triplet Formation of Chromophoric Dissolved Organic Matter

Abstract Carboxylation and decarboxylation are among the most ubiquitous processes in chromophoric dissolved organic matter (CDOM) transformation, occurring during humification, photooxidation, and microbial activity. However, their impacts on the formation of excited triplet-sta...

Electronic Structure Modulation of NiCo 2 S 4 Hollow Dodecahedrons by In Situ Compositing MoS 2 for Boosted Reaction Kinetics in Li–O 2 Batteries

ABSTRACT Rechargeable Li–O 2 batteries have attracted significant attention as a next‐generation energy storage technology because of their extremely high theoretical energy density. However, practical implementation remains hindered by limited energy density, poor cycling stabil...

Nanomedicines for resistant tumours in the central nervous system: novel materials and mechanisms of action

Central nervous system (CNS) tumours have a dismal prognosis, primarily due to the systemic therapeutic resistance that tumours develop through complex multidimensional networks. Factors related to therapeutic efficacy include: (i) natural physical barriers (e.g., the blood–brain...

Percolation transition of K -destinations reveals universal backbone of urban mobility networks

Abstract Cities are held together by a small subset of recurrent origin–destination ties, but extracting this backbone from noisy mobility data remains difficult, and most models still prioritize distance over connectivity. We build directed mobility networks from 48 months of mo...

Bis-Nitrene Prevails: Ligand-Controlled Divergence from the Conventional Mononitrene Pathway in Dirhodium Catalysis

Abstract Dirhodium paddlewheel complexes are widely used in C–H amination, yet whether bis-nitrene intermediates participate in catalysis remains an open question. Through systematic DFT calculations at the M06L/dgdzvp/SMD level, we show that both axial and bridging ligands exert...

Computer-Assisted Workflow for DNA Origami-Engineered Triangular Nanopores

Abstract Synthetic nanopores engineered by DNA origami provide a highly biocompatible and structurally programmable platform for elucidating the transmembrane mechanisms of functional macromolecules. However, engineering large DNA nanopores exceeding 30 nm in width remains a sign...

Operator Inference for Elliptic Eigenvalue Problems

Efficient computation of elliptic eigenvalue problems is critical in science and engineering. In this paper, we propose a novel operator learning framework that directly maps arbitrary domains to their associated eigenvalues and eigenfunctions. Our approach employs a hybrid archi...

Anion‐Transferring Electrolyte Enables In Situ Construction of Uniform LiF‐Rich Interphases for Long‐Cycling Lithium–Sulfur Batteries

ABSTRACT Stabilizing electrode/electrolyte interphases is crucial for high‐performance lithium–sulfur batteries; however, simultaneously fabricating robust interphases on both the lithium anode and sulfur cathode is challenging. Here, we report an anion‐transferring functional el...

Depth-dependent response of a liquefiable sand deposit to repeated electrolysis-induced desaturation

Introducing a discrete gas phase into saturated sand reduces the bulk modulus of the pore fluid, but the response of deep deposits to repeated electrolysis-induced desaturation (EID) has received limited field evaluation. A field trial lasting 45 days comprised three energisation...

Oxytocin modulates white matter functional connectivity tensor dynamics and circuit-targeted reconfiguration in depressive symptoms

Major depressive disorder involves disrupted neural circuit dynamics. While oxytocin has demonstrated modulatory effects on functional connectivity, its therapeutic potential for depression, particularly through white matter circuit modulation, remains poorly understood. Here we...

Decoupled Synthesis Pathway via Precursor Functionalization Stabilizes High‐Voltage Nickel‐Based Cathodes

ABSTRACT Nickel‐based layered cathodes are promising candidates for high‐performance, high‐energy lithium‐ion batteries, yet their high‐voltage application is jointly limited by synthesis‐inherited structural defects and an unstable lattice oxygen framework. Here, we show that bo...

Prioritizing key performance indicators for maintenance management in public hospitals: a hybrid SEM–machine learning approach

Purpose Public hospital maintenance operates under growing service pressure, yet existing frameworks often rely on data-intensive systems or broader facility outcomes, offering limited guidance on which maintenance key performance indicators (KPIs) should be prioritized under res...