University of Health Sciences Antigua

Development of a Plant Bioactive-Rich Tahini-Based Powder Enriched with Pea Protein and Coconut Milk Powder: Antioxidant Properties, Nutritional Characterization, In Vitro INFOGEST Static Digestion

This study aimed to develop a spray-dried tahini-based powder enriched with pea protein and coconut milk powder and to comprehensively characterize its plant bioactive composition, antioxidant potential, nutritional properties, and bioaccessibility following the standardized INFO...

Engineering Red Blood Cell Membrane-Coated PLGA Nanoparticles for Kahweol Delivery: Formulation Development and Pharmacokinetic Assessment

Kahweol is an active diterpene with anti-inflammatory, antioxidant, and anticancer properties; however, its use may be limited by unfavorable pharmacokinetic characteristics. This study aimed to develop kahweol-loaded poly(lactic-co-glycolic acid) (PLGA) and red blood cell membra...

Green-Synthesized Mesoporous Silica-Enhanced Herbal Nanofibers with Antimicrobial, Anti-Inflammatory, and Biocompatible Wound Healing Potential

Advanced wound dressings should actively promote tissue repair while preventing microbial infection and excessive inflammation. In this study, multifunctional electrospun nanofibers composed of poly(vinyl alcohol)/chitosan/gelatin were developed by incorporating green-synthesized...

Modified Endothelial Activation and Stress Index (mEASIX) Predicts Long-Term Mortality in Patients with Acute Coronary Syndromes

Endothelial dysfunction, inflammation, and microvascular injury are key mechanisms involved in the development and progression of acute coronary syndrome (ACS). The Endothelial Activation and Stress Index (EASIX) and its derivatives have emerged as readily available biomarkers of...

Therapeutic Effects of Ganoderma lucidum Against Aβ-Induced Neurotoxicity in SH-SY5Y Cells: In Vitro Evidence and Computational Validation of Human Protein Targets

The triterpenoid and polysaccharide constituents of Ganoderma lucidum (GL) are believed to influence key pathogenic pathways in Alzheimer’s disease (AD). This study first examined the molecular rationale for GL’s neuroprotective properties by subjecting its principal triterpenoid...

Water Dissociation on Molybdenum and Tungsten Oxide Trimers: Roles of Oxidation State, Structure, and Microsolvation

Abstract Here we present results of a density functional theory based systematic investigation of water adsorption and dissociation on Mo3O9/Mo3O8 and W3O9/W3O8 clusters. For fully oxidized Mo3O9 and W3O9, adsorption of a single water molecule is strongly exothermic (−0.81 and −0...

Posterior mediastinal unicentric Castleman disease treated by video-assisted thoracoscopic surgery

Castleman disease (CD) represents an uncommon lymphoproliferative condition that can manifest as a mediastinal mass and resemble other thoracic pathologies. Establishing a definitive diagnosis before surgery is often difficult, making histopathological analysis crucial. We presen...

The “Lock‐and‐Key” Advantage: Molecularly Imprinted Polymers in Modern Electrophoresis in Drug Assay

Molecularly imprinted polymers (MIPs) have gained increasing attention as synthetic recognition materials that mimic biological binding sites while offering greater stability and lower cost. In recent years, their combination with electrophoretic techniques has opened new possibi...

Clinical Impact of Fingolimod-Associated Lymphopenia in Multiple Sclerosis: A Real-World Cohort Study

Background and Objectives: Fingolimod, a sphingosine-1-phosphate receptor modulator, is an effective disease-modifying therapy for relapsing forms of multiple sclerosis (MS). Although lymphopenia is a well-recognized pharmacological effect, its clinical significance remains uncer...

Septal Perforation Repair Improves Olfaction and Mucociliary Clearance: A Prospective Study

OBJECTIVE: Nasal septal perforation (NSP) disrupts normal nasal physiology and may lead to significant functional symptoms. This study aimed to prospectively evaluate changes in olfactory function, nasal mucociliary clearance (MCC), and quality of life (QOL) following septal perf...

Meteorological factors and daily afebrile seizure counts in children: a time-series analysis

Abstract Background The relationship between meteorological factors and seizure occurrence remains controversial, particularly in pediatric populations where data are limited and may be confounded by febrile seizures. This study aimed to investigate the association between daily...

Is 400 Gy enough for every tumor? The 3 cm cutoff and a modified BCLC classification for predicting complete response after radiation segmentectomy in hepatocellular carcinoma

To evaluate the relative contribution of the 400 Gy perfused liver absorbed dose (PLAD) threshold and tumor size in predicting complete response (CR) after yttrium-90 (Y-90) radiation segmentectomy (RS) in hepatocellular carcinoma (HCC), and to investigate the prognostic discrimi...

External Validation of Clinical Risk Scores and Machine Learning Models for Predicting 30-Day Cardiovascular Risk After Noncardiac Surgery: The PERICARE Study

Background: Machine learning (ML) has emerged as a promising approach for preoperative cardiovascular risk prediction; however, the generalizability of ML models across institutions remains uncertain. Moreover, comprehensive head-to-head comparisons between ML algorithms and esta...

Increased HIF-2α and CD105 (endoglin) expression is associated with poor differentiation in pheochromocytomas and paragangliomas

Objective Reliable biomarkers reflecting tumor biology and histopathological risk status in pheochromocytomas and paragangliomas (PPGL) remain limited. In this study, the expression of biomarkers associated with hypoxia, angiogenesis, and proliferation was evaluated, and their as...

Performance of large language models and pediatricians in complex pediatric scenarios: a prospective, randomized comparative study of clinical task accuracy and decision support

To compare response accuracy between contemporary large language models (LLMs) and pediatricians across difficulty-stratified pediatric clinical vignettes, characterize LLM response times, and quantify the effect of AI-generated outputs on pediatrician decisions. In a prospective...

Development and effectiveness of a user-centered mobile application for informal caregivers of people living with dementia: randomized controlled trial

Abstract Background Dementia places substantial physical, psychological, and social demands on informal caregivers, and caregiving needs may change across the dementia trajectory as cognitive, behavioral, and functional changes alter day-to-day care demands. Digital interventions...

Effective Protection Against Alcohol-Related Cardiac Damage: Dapagliflozin

Chronic alcohol consumption causes serious damage to the liver and cardiovascular system and leads to neoplastic lesions in various organs such as the esophagus, liver, and breast. In our study, we evaluated the protective effects of standard and high doses of dapagliflozin again...

Changes in Premenstrual Syndrome Severity, Nutrition Knowledge, and Eating Attitudes Following Online Nutrition Education in Female University Students: An Uncontrolled Single-Arm Pretest–Posttest Study

Background/Objectives: This study evaluated changes in PMS severity, nutrition knowledge, and eating attitudes over a 6-week online nutrition education programme delivered to female university students. Methods: This uncontrolled single-arm pretest/posttest study included 112 fem...

Kinetics modelling of degradation process of organic pollutants in Ajali River Enugu, Nigeria

Kinetics and modelling of organic pollutants biodegradation in Ajali River was studied. Dissolved oxygen (DO) was determined using Winkler-Azide method, while biochemical oxygen demand (BOD) was determined after five days of incubation. Kinetic study was achieved using Streeter–P...

Association Between the Neutrophil-to-Lymphocyte Ratio and Recurrence in Idiopathic Granulomatous Mastitis

Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease with a relapsing course. The neutrophil-to-lymphocyte ratio (NLR) has been investigated as a potential inflammatory biomarker in various diseases. This study aimed to evaluate the association be...