University of Health Science

The “Lock‐and‐Key” Advantage: Molecularly Imprinted Polymers in Modern Electrophoresis in Drug Assay

Molecularly imprinted polymers (MIPs) have gained increasing attention as synthetic recognition materials that mimic biological binding sites while offering greater stability and lower cost. In recent years, their combination with electrophoretic techniques has opened new possibi...

Posterior mediastinal unicentric Castleman disease treated by video-assisted thoracoscopic surgery

Castleman disease (CD) represents an uncommon lymphoproliferative condition that can manifest as a mediastinal mass and resemble other thoracic pathologies. Establishing a definitive diagnosis before surgery is often difficult, making histopathological analysis crucial. We presen...

Clinical Impact of Fingolimod-Associated Lymphopenia in Multiple Sclerosis: A Real-World Cohort Study

Background and Objectives: Fingolimod, a sphingosine-1-phosphate receptor modulator, is an effective disease-modifying therapy for relapsing forms of multiple sclerosis (MS). Although lymphopenia is a well-recognized pharmacological effect, its clinical significance remains uncer...

Effective Protection Against Alcohol-Related Cardiac Damage: Dapagliflozin

Chronic alcohol consumption causes serious damage to the liver and cardiovascular system and leads to neoplastic lesions in various organs such as the esophagus, liver, and breast. In our study, we evaluated the protective effects of standard and high doses of dapagliflozin again...

External Validation of Clinical Risk Scores and Machine Learning Models for Predicting 30-Day Cardiovascular Risk After Noncardiac Surgery: The PERICARE Study

Background: Machine learning (ML) has emerged as a promising approach for preoperative cardiovascular risk prediction; however, the generalizability of ML models across institutions remains uncertain. Moreover, comprehensive head-to-head comparisons between ML algorithms and esta...

Performance of large language models and pediatricians in complex pediatric scenarios: a prospective, randomized comparative study of clinical task accuracy and decision support

To compare response accuracy between contemporary large language models (LLMs) and pediatricians across difficulty-stratified pediatric clinical vignettes, characterize LLM response times, and quantify the effect of AI-generated outputs on pediatrician decisions. In a prospective...

Prevalence and prognostic significance of obstructive sleep apnea in patients with idiopathic pulmonary fibrosis: A prospective cohort study

ABSTRACT BACKGROUND: Obstructive sleep apnea (OSA) is a recognized comorbidity in idiopathic pulmonary fibrosis (IPF); however, its true prevalence remains uncertain, and its prognostic implications have not been fully elucidated. This study aimed to determine the prevalence of a...

Biceps brachii and forearm muscle morphology related to forearm and hand deformities in spastic cerebral palsy

Introduction: Previous studies have identified morphological alterations in spastic muscles focusing predominantly on gross motor muscles, with specific emphasis on those of the lower limbs. There is minimal information on the morphology of spastic upper limb muscles in relation...

Storage symptom burden in women with obesity is associated more with age and smoking than metabolic biomarkers: prospectively collected cross-sectional data

Obesity frequently coexists with insulin resistance and lower urinary tract symptoms, but the independent contribution of metabolic abnormalities among women with obesity is uncertain. We analyzed prospectively collected cross-sectional data from 139 women with body mass index ≥...

Omphalocele with Patent Omphalomesenteric Duct and Intestinal Prolapse in a Preterm Neonate: Histopathological Evidence of Incomplete Vitelline Duct Involution

Patent omphalomesenteric duct (OMD) with intestinal prolapse coexisting with omphalocele is an exceptional ventral folding anomaly that may be misdiagnosed as gastroschisis. The vitellointestinal duct normally involutes between the seventh and ninth gestational weeks; failure of...

Intermediate-Term Oncological, Anastomotic and Nutritional Outcomes of the Sutureless L-Shaped Esophagojejunostomy with Endoscopic Assistance (SLEJ) in Totally Laparoscopic Total Gastrectomy: A Follow-Up Analysis of This Technique

Background and Objectives: Intra-corporeal esophagojejunostomy after totally laparoscopic total gastrectomy (TLTG) remains one of the most technically demanding steps of minimally invasive gastric surgery. The management of the common entry hole in linear stapler-based reconstruc...

Early mRNA expression of pro-inflammatory cytokines and ADAMTS-5 in an acute ischemia/reperfusion–induced pressure ulcer model, a pilot exploratory animal study

Objectives: This study aimed to determine the messenger ribonucleic acid (mRNA) expression levels of interleukin (IL)-1α, IL-1β, IL-6, IL-17, and A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) -5 in an acute ischemia/reperfusion (I/R)-induced pressure ulc...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

ROX index and NEWS2 for 28-day mortality prediction in emergency department patients with acute dyspnea: a prospective observational study

Acute dyspnea is a frequent and high-risk presentation in emergency departments (ED), requiring rapid identification of patients at increased risk of deterioration and mortality. This study aimed to compare the accuracy of the Respiratory Rate–Oxygenation (ROX) index and National...

Fine-needle–based localization techniques in parathyroid adenomas: a retrospective cohort study of histopathological safety and fibrosis patterns

Abstract Background This study aimed to evaluate the association between fine-needle-based interventions widely used for preoperative and intraoperative localization of parathyroid adenomas and the development of post-excision stromal fibrosis and other histopathological changes...

Shoulder MRI for Forensic Age Estimation: Ossification Staging of the Proximal Humeral Epiphysis

Background/Objectives: Magnetic resonance imaging (MRI) of the proximal humeral epiphysis offers a radiation-free alternative for forensic age estimation in living individuals. This study aimed to characterize the relationship between chronological age and epiphyseal maturation u...

Evaluation of Alexithymia Level in Children With Cystic Fibrosis

The present study sought to determine the extent of alexithymia within the cystic fibrosis (CF) population and examine how it relates to both the severity of the illness and the effectiveness of patient disease management strategies. The study sample included adolescents aged 14...

Does the mother’s cooking skills influence the school-aged child’s adherence to the Mediterranean diet in Turkiye? a cross-sectional study

This cross-sectional descriptive study was designed and conducted to assess the effect of mothers’ cooking skills on school-aged children’s adherence to the Mediterranean diet. The demographic characteristics and anthropometric measurements of 388 mothers and children were collec...

The relationship between the uric acid to prealbumin ratio and frailty, muscle strength, and malnutrition risk in older geriatric outpatients: a retrospective cross-sectional study

Frailty, sarcopenia, and malnutrition are common in older adults; however, simple biomarkers reflecting both inflammatory and nutritional status remain limited. We aimed to evaluate the relationship between the uric acid-to-prealbumin ratio (UPR) and frailty, muscle strength, and...

Comparative Evaluation of ChatGPT-5.2, Claude Sonnet 4.5, and DeepSeek for Rosacea-Related Information: Accuracy, Reliability, Readability, and Reference Hallucinations

Background/Objectives: Rosacea is a chronic inflammatory skin disease that requires long-term management and continuous patient education regarding triggers, skincare practices, and treatment adherence. In recent years, patients have increasingly turned to online platforms and ar...