University of Health Science

Incremental Anatomical Value of CT Angiography Beyond Echocardiography in the Preoperative Assessment of Pediatric Conotruncal Anomalies: A Surgical Correlation Study

Background: Conotruncal anomalies frequently involve extracardiac vascular structures that are critical for surgical planning yet incompletely assessed by transthoracic echocardiography (TTE). We evaluated the incremental diagnostic value of CT angiography (CTA) beyond TTE using...

Evaluation of the pSOFA Score in a Pediatric Intensive Care Unit and Its Discriminative Performance Compared with PRISM 4 and PIM 3

Objectives: We aimed to evaluate the performance of the age-adapted Pediatric Sequential Organ Failure Assessment (pSOFA) score, as a predictor of mortality in patients admitted to pediatric intensive care units (PICUs), and to compare it with the Pediatric Risk of Mortality 4 (P...

Effectiveness of vestibular electrical stimulation combined with vestibular rehabilitation in chronic unilateral vestibular hypofunction: A randomized controlled trial

Objectives: To evaluate the effectiveness of vestibular electrical stimulation (VES) combined with vestibular rehabilitation (VR) in patients with chronic unilateral vestibular hypofunction (UVH). Patients and Methods: Forty patients aged 18-65 years, diagnosed with UVH, were ran...

Depression, anxiety and stress symptoms in women with polycystic ovary syndrome with and without fertility treatment and in non-PCOS controls: a cross-sectional comparative study

Abstract Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder of reproductive-aged women that has been linked to psychological difficulties such as depressive and anxiety symptoms. We compared Depression Anxiety Stress Scale-21 (DASS-21) scores between women...

Clinical Outcomes in Initial Hirudotherapy versus Standard Treatment in Idiopathic Granulomatous Mastitis: A Comparative Cohort Study

Objective: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disease characterized by a high risk of recurrence and fistula formation. Spontaneous remission has been reported in up to 50% of cases, particularly in mild forms, within 6-24 months without interventio...

Evaluation of the accuracy and reproducibility of large language models (ChatGPT, DeepSeek, Gemini) in responding to patient-centered lipedema questions

Background Lipedema is a frequently misdiagnosed chronic condition that significantly impacts patients’ quality of life. As artificial intelligence (AI)-based large language models (LLMs) become increasingly integrated into healthcare communication, their accuracy and consistency...

Machine Learning and MILP for Capacity Optimization and Educational Workload in Academic Endodontics

ABSTRACT Objectives Appointment scheduling in endodontic clinics is challenging due to heterogeneous treatment durations and varying practitioner competencies. Conventional scheduling methods frequently overlook these complexities, leading to underutilized unit capacity, extended...

The Frontal QRS-T Angle and Cardiovascular Disease: A Narrative Review of Electrophysiological Basis, Measurement, and Clinical Utility

The QRS-T angle quantifies the divergence between the vectors of ventricular depolarization and repolarization and is regarded as a surrogate for global heterogeneity of ventricular repolarization. Its frontal-plane variant, calculated as the absolute difference between the autom...

Association of Monocyte Subsets with Carotid Artery Stenosis Severity

Background and Objectives: This study aimed to investigate the association between circulating monocyte subset profiles and carotid artery stenosis (CAS) severity and to examine their relationships with inflammatory and atherosclerosis-related parameters. Materials and Methods: T...

Serum CXCL-10 and CTLA-4 levels in treatment-naive chronic hepatitis B: associations with EASL-based clinical phenotypes, histological inflammatory activity, and non-invasive fibrosis indices

Chronic hepatitis B (CHB) is a major global health issue, as ongoing viral replication can drive hepatic inflammation and immune dysregulation, increasing the risk of cirrhosis and hepatocellular carcinoma. CXCL-10, a proinflammatory chemokine, and CTLA-4, an inhibitory immune ch...

Clinical Utility of the Atherogenic Plasma Index for Identifying Atherogenic Dyslipidemia: A Large Cross-Sectional Analysis Stratified by Sex and Thyroid Status

Background: The atherogenic plasma index (AIP) has emerged as a promising marker reflecting the balance between triglyceride (TG)-rich lipoproteins and high-density lipoprotein cholesterol (HDL-C). However, its clinical utility in identifying atherogenic dyslipidemia (AD), partic...

Performance-based functional assessment in ankylosing spondylitis: Clinical utility and validation of the Back Performance Scale (BPS-TR)

Background Self-report questionnaires are commonly used to assess functional status in patients with ankylosing spondylitis (AS). However, these instruments may not fully reflect patients’ actual physical performance. The Back Performance Scale (BPS-TR) may provide a more objecti...

From Metabolism to Molecular Phenotype: Carbonic Anhydrase IX–Targeted [ 68 Ga]Ga-DPI-4452 PET/CT in Renal Cell Carcinoma: A Prospective Multicenter Comparison with [ 18 F]FDG PET/CT

The objective of this study was to prospectively compare the diagnostic performance, lesion detection capability, and clinical staging impact of [68Ga]Ga-DPI-4452 PET/CT with that of [18F]FDG PET/CT in renal cell carcinoma (RCC) using a multicenter design. Methods: Sixty-eight pa...

Microbiological monitoring of scuba cylinders under routine filling and seasonal diving conditions

Introduction: The aim of this study was to monitor the microbiological status of the inner surfaces of scuba cylinders under routine air filling conditions and to assess whether microbiological contamination emerges or persists over time. Methods: A prospective longitudinal micro...

Investigation of functional independence and developmental areas in preschool children with quadriplegic cerebral palsy and cortical visual impairment

Cerebral palsy (CP) is a neurodevelopmental condition that affects areas of development and functional independence. Cortical Visual Impairment (CVI) is an important problem frequently observed in children with CP. This study was planned to compare the functional independence and...

Engineering Red Blood Cell Membrane-Coated PLGA Nanoparticles for Kahweol Delivery: Formulation Development and Pharmacokinetic Assessment

Kahweol is an active diterpene with anti-inflammatory, antioxidant, and anticancer properties; however, its use may be limited by unfavorable pharmacokinetic characteristics. This study aimed to develop kahweol-loaded poly(lactic-co-glycolic acid) (PLGA) and red blood cell membra...

Comparing clinicopathological factors and quantitative background parenchymal enhancement to predict pathological complete response after neoadjuvant chemotherapy in breast cancer

PURPOSE: To investigate the predictive value of deep learning (nnU-Net)-based fully automated quantitative background parenchymal enhancement (BPE) metrics and clinicopathological factors for pathological complete response (pCR) in patients with breast cancer receiving neoadjuvan...

Arthroscopic Free Bone Block Transfer Technique Using Iliac Crest Autograft With Anchor‐Button Fixation for Glenohumeral Instability and Glenoid Bone Loss

Abstract Bone block transfer for the treatment of glenohumeral instability with severe glenoid bone loss or multiple recurrences has grown in popularity in recent years. In this technical note, we described an arthroscopic‐assisted free bone block transfer technique, using a spec...

Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report

This article presents a case demonstrating that valproic acid, which is widely used in the treatment of bipolar disorder, can lead to hyperammonemic encephalopathy, a rare but potentially serious adverse effect.

Water Dissociation on Molybdenum and Tungsten Oxide Trimers: Roles of Oxidation State, Structure, and Microsolvation

Abstract Here we present results of a density functional theory based systematic investigation of water adsorption and dissociation on Mo3O9/Mo3O8 and W3O9/W3O8 clusters. For fully oxidized Mo3O9 and W3O9, adsorption of a single water molecule is strongly exothermic (−0.81 and −0...