University of Groningen

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...

An ecosyndemic framework for understanding obesity: Spatial clustering of health, environmental and socioeconomic disadvantage in the Netherlands

Abstract Introduction Obesity and related health conditions are unevenly distributed across neighborhoods, often co-occuring with multiple health challenges and socioeconomic disadvantages. Using an ecosyndemic framework, which integrates ecological and social dimensions that con...

An Alternative Approach to Compute the Likelihood for the DAISIE (Dynamic Assembly of Island Biota Through Speciation, Immigration, and Extinction) Model

Abstract Understanding island biodiversity requires studying the processes driving its assembly and examining how these processes vary over time, across lineages, and across different islands. The DAISIE (Dynamic Assembly of Island biota through Speciation, Immigration, and Extin...

Neutron elastic scattering at $$\varvec{30.8}$$ MeV on $$\varvec{^{\text {nat}}\textrm{Ce}}$$

Abstract Elastic scattering of fast neutrons at an incident energy of 30.8 MeV on a natural cerium target was measured during an experiment conducted at the Neutrons For Science facility at GANIL-SPIRAL2. This is the first measurement on cerium using incident neutron energy above...

Spatial qubit entanglement witness for quantum natured gravity

Abstract Witnessing the quantum nature of gravity through the entanglement of two masses has recently been proposed. Both non-Gaussian and Gaussian protocols have been shown to be useful for this purpose. In non-Gaussian protocols the complete 1/r gravitational interaction can in...

Long‐Term Persistence and Treatment Changes of Antihypertensive Therapy: A 5‐Year Cohort Study

ABSTRACT Aim To estimate persistence with antihypertensive therapy (AHT) and describe treatment changes and associated factors among persistent patients over 5 years. Methods We conducted a longitudinal cohort study using the IADB.nl pharmacy database in the Netherlands, includin...

Cardiovascular Risk Prediction with the Kidney Failure Risk Equation in the Chronic Renal Insufficiency Study

Background: The Kidney Failure Risk Equation (KFRE) is an established tool to predict the risk of kidney failure among patients with CKD. Patients with CKD more often die from cardiovascular (CV) causes than renal causes, and more often experience a non-fatal CV event than progre...

Beyond Branching: Unlocking the Catalytic Versatility of Branching Enzymes for the Design of Diverse α-Glucan Structures

Starch-modifying glycoside hydrolases (GHs) typically operate via a retaining double-displacement mechanism, involving formation of a covalent glycosyl–enzyme intermediate. This intermediate can be resolved either by water, resulting in hydrolysis, or by a glucan acceptor, leadin...

Liver-directed gene therapy results in amelioration of progressive familial intrahepatic cholestasis type 2 in mice

Background: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare disease affecting the ABCB11 gene, encoding the bile salt export pump (BSEP). BSEP dysfunction impairs bile acid (BA) secretion, causing hepatic damage and leading to pruritus, cholestasis, hepatom...

The impact of nephrectomy on liver and contralateral kidney volume in patients with ADPKD; a case series

A substantial number of patients with autosomal dominant polycystic kidney disease (ADPKD) undergo nephrectomy. A decrease in intra-abdominal pressure after nephrectomy might hypothetically accelerate the growth of other polycystic organs and accelerate the rate of eGFR decline o...

The Dutch cardiomyopathy registry (DCR); rationale and registry design

BACKGROUND: Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-q...

Recovery trajectories and predictors of symptom resolution in post-COVID-19 condition: a population-based cohort study

Background SARS-CoV-2 infection can lead to persistent symptoms, known as Post-COVID-19 Condition (PCC). Previous studies on PCC prognosis mainly looked at severe cases in rehabilitation settings and without knowledge about pre-infection symptom levels. Uncertainty remains about...

Planetesimal Formation Across the Stellar Mass Spectrum and its Influence on Exoplanet-Inherited Volatile Budgets

Abstract Protoplanetary discs emerging from collapsing molecular clouds are capable of forming planetesimals at the water snowline during both the cloud collapse and Class II disc phases; such a scenario could be responsible for creating the carbonaceous/non-carbonaceous (CC/NC)...

Using the Interpersonal Theory of Suicide to Inform Our Understanding of Suicide Risk in Autism Spectrum Disorder: A Scoping Review

Abstract This scoping review is the first to systematically map the literature on suicidality in autistic adults through the lens of Joiner’s Interpersonal Theory of Suicide (ITS). Reviewing 51 studies and distinguishing between those directly assessing ITS constructs and those c...

Effect of genetic factors on [18F]FDG PET metabolic phenotypes in dementia with Lewy bodies

BACKGROUND: F]FDG PET can support the diagnosis of Dementia with Lewy Bodies (DLB), but it remains unclear how genetic factors influence metabolic phenotypes. OBJECTIVES: F]FDG PET metabolic patterns in DLB. METHODS: F]FDG PET scans from 43 patients with DLB stratified by GBA1 an...

Visual strategies in influencer marketing campaigns: The role of consistency

Abstract This research analyzes the role of visual features in influencer marketing campaigns, focusing on visual consistency within campaigns. Using 707 posts and 1,105 stories from 182 campaigns, we extract 47 visual and consistency features along four fundamental visual dimens...

Community engagement in epidemics – experiences from the SoNAR-Global COVID-19 vulnerability assessment

Since the largest outbreak of Ebola Virus Disease 2014–2016, the concept of community engagement (CE) gained popularity in global frameworks and strategies to tackle infectious disease. Recent studies suggest that CE might be a useful approach to understand and resolve vulnerabil...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

A proposed approach for involving general practice in integrated oncological decision-making for frail patients

As populations age, the number of older adults (≥70 years) diagnosed with cancer is increasing, now accounting for the majority of new cancer diagnoses and experiencing the highest treatment burden. Treatment decision-making in this population is often complex, as multimorbidity,...

Deep learning for assessing corneal endothelial cell density in patients after descemet membrane endothelial keratoplasty: towards improved evaluation

Descemet membrane endothelial keratoplasty (DMEK) represents a pivotal advance in corneal transplantation, specifically targeting cases of endothelial dysfunction. Postoperative monitoring of endothelial cell density (ECD) is critical for graft health and patient outcomes. Theref...