University of Groningen

SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA

RNA-targeting small molecules are emerging as promising therapeutic modalities, but their development requires methods that define binding sites and evaluate RNA target selectivity. Existing approaches for detecting ligand-RNA interactions have provided powerful foundations, yet...

From fragmentation to facilitation? Governing port-led metropolitan growth in West Java through Metropolitan by Design

Ports increasingly shape metropolitan development, yet governments often struggle to coordinate land use, infrastructure, and investment decisions related to port expansion. Fragmented authority and overlapping mandates limit planning authorities’ ability to coordinate developmen...

Turning ecology into economy: who provides biodiversity knowledge for institutional investors?

Biodiversity is emerging as a material issue for institutional investors, driven by a growing concern for nature-related risks. This presents a challenge to the financial sector as institutional investors require metrics and tools to develop their investment strategies. Yet, biod...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...

Mucosal melanoma in 1481 patients in the Netherlands. An overview of metastatic patterns, main driver mutations and the efficacy of therapeutic strategies

Mucosal melanomas are a rare melanoma subtype with poor prognosis. This project aimed to identify the main driver mutations of the different mucosal melanomas and to evaluate the efficacy of targeted/immunotherapies in patients with metastatic disease in current practice. In addi...

The hunger games: procurement strategies under unmitigable supplier dominance

Purpose Most procurement research assumes that buyers possess negotiation power and viable alternatives. However, such assumptions do not hold in practice, as buyers in many industries operate under unmitigable supplier dominance. Against this backdrop, we examine how weaker buye...

Early Radiographic Changes Predict Radiographic Stability in Distal Radius Fractures: Development and Validation of an Explainable Predictive Model

Purpose To determine whether early radiographic trajectory data can predict the timing of stability in conservatively managed distal radius fractures (DRFs) and to identify which clinical and radiographic features most influence stabilization timing. Methods This retrospective co...

Public responses to jihadist terrorism on social media

In recent years, several major terror attacks in the name of political Islam have shaken Europe. This study analyzes public responses after such attacks to explore their impact on public views of immigration and intergroup relations. In particular, the study examines how public r...

Categorizing race profiles in professional men’s and women’s road cycling races using clustering

Abstract Background Professional road cycling races differ in physiological demands because race profiles vary. Yet no standardized method exists to categorize race profiles across professional road cycling races. Organizer labels are inconsistent or missing. Systematic categoriz...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

The physicochemical design, structure and permeability of the JCVI-syn3A minimal cell membrane

Abstract Minimal cells offer a platform to uncover the fundamental physicochemical principles of cellular life. While genomes, proteomes and metabolic networks of cells have been elucidated, the lipidome, which determines the physicochemical identity of the membrane, remains larg...

Functional mapping and engineering of the Sec translocon unlocked by a cell-free system

Abstract Almost all proteins are inserted or translocated across membranes by the universally conserved Sec translocon. Despite its central role, experimental access to Sec function has remained limited. Here, we present a cell-free protein synthesis platform that inserts SecYEG...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Developing an interprofessional self-reflection logbook in reproductive health in low-middle income countries: educational design research

PURPOSE: Remoteness from institutions challenges supervision in interprofessional education (IPE) in a community setting in reproductive health in low- and middle-income countries (LMIC). In this setting, IPE would benefit from an instrument that supports self-reflection. The use...

Ligand binding free energy landscapes at the tubulin colchicine site from coarse-grained metadynamics

Accessing deeply buried binding sites remains a major challenge in structure-based drug discovery, where accurate description of both protein dynamics and ligand binding pathways is required. All-atom funnel metadynamics (AA-FMD) enables simulation of complete binding processes b...

Interprofessional identity development: awareness as the beginning of change

Abstract Background: Developing an interprofessional identity (IPI) generates an intrinsic motivation for interprofessional collaboration owing to pro-diversity beliefs that mitigate identity threat within dynamic teams. However, personal experiences and contextual changes such a...

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer

Abstract Identifying pathogenic germline variants in men with metastatic prostate cancer is important for therapeutic options and for identifying relatives who may have a high cancer risk. To keep genetic testing costs manageable, it is important to identify which patients should...

Long-term outcomes of childhood ADHD stimulant use trajectories

Background. Stimulant medication is the first-line pharmacological treatment option for children with attention-deficit/hyperactivity disorder (ADHD). However, long-term effects remain unclear. Therefore, we explored long-term (>12 years) outcomes of childhood stimulant medicatio...

Long-Term Clinical Outcomes of Symptom Overreporting and Cognitive Underperformance in Adult ADHD Assessments

Abstract Invalid responding can bias clinical judgement, particularly in adult attention-deficit/hyperactivity disorder (ADHD), where rates of symptom overreporting and cognitive underperformance are elevated. Performance validity tests (PVTs) and symptom validity tests (SVTs) ar...