University of Groningen

Obesity, incretin-based therapies, and cardiovascular disease in women

Abstract Obesity in women is a growing and multifaceted public health challenge, driven by complex interactions among biological, hormonal, and psychosocial factors across the life course. From menarche to menopause, hormonal fluctuations influence fat distribution, energy balanc...

XID+PRIMA, II: Stepping Through Hyperspectral Imaging to Deblend PRIMAger Beyond the Extragalactic Confusion Limit

The PRobe far-Infrared Mission for Astrophysics concept aims to map large areas with spectral coverage and sensitivities inaccessible to previous FIR space telescopes, covering 25-235um. We synthesise images representing a deep imaging survey, with realistic instrumental and conf...

The role of the third sector in China’s agri-food transitions: Integrating transformative social innovation and the state–society paradigm

The third sector is increasingly recognised as a key driver of transformative change in the agri-food system, though its potential depends largely on the institutional context. This study integrates transformative social innovation theory with a state–society framework to examine...

Seeding Norms by Making the Invisible Visible in a Field Study on Pro-Environmental Change

Most people are concerned about environmental issues, but underestimate others’ concern due to a lack of visible pro-environmental behaviour. This misperception creates a cycle of inaction, as people are less likely to act sustainably when they assume others do not share their pr...

Understanding involvement in energy communities: the role of energy citizenship and community factors

Energy communities (ECs) are collective initiatives in which citizens jointly engage in the production, distribution and storage of renewable energy. Through their involvement in ECs, citizens take responsibility for contributing to the energy transition, often conceptualised as...

An innovative two-step catalytic process for the conversion of kraft lignin to biofuels

Valorisation of lignins to biofuels and biobased chemicals is of high interest to stimulate the necessary transition from a fossil-based to a biobased economy. This study presents the experimental validation of the ABC-Salt process for the conversion of a Kraft lignin (Lignoboost...

Different strokes for different folks: Remote work, heterogeneity, and restructuring of relocation networks in the Netherlands

Remote work is relaxing conventional workplace-residence constraints, yet how it reorganizes relocation systems remains unclear. Existing studies largely focus on individual moves or place-level population change, with less attention to the direction of origin-destination structu...

Distant and Distressed: Interpersonal Problems in Anxiety and Depression

ABSTRACT Objectives Interpersonal functioning has a complex, bidirectional relationship with mental disorders such as anxiety and depression. The Inventory of Interpersonal Problems (IIP) assesses aspects of interpersonal functioning, including general interpersonal distress and...

Radium-223 decreases PD-L1 expression in bone metastases: A study with [89Zr]Zr-atezolizumab PET and immunohistological correlation

Abstract Purpose Most patients with metastatic castration-resistant prostate cancer (mCRPC) do not benefit from treatment with immune checkpoint inhibitors targeting programmed cell death (ligand) 1 (PD-(L)1). Radiation might improve response to immunotherapy by increasing the im...

Reassessment of a cosmic ray increase event in 1279/1280 CE using carbon-14 records of tree rings.

Extreme solar energetic particle events (ESPEs) rarely occur on the Sun, as known from cosmogenic isotope proxies, the primary being 14C measured in tree rings. Several such events have been identified in tree-ring 14C data as sharp spikes. The most recent spike, around 1279 CE,...

Thiophenol-Based Designer Enzymes for Asymmetric Hydrogen/Deuterium Atom Transfer

Abstract The enantioselective control of short-lived radical species in aqueous media represents a major challenge in modern catalysis. Herein, we report on the design and evolution of a designer enzyme with a genetically encoded thiophenol moiety that enables enantioselective hy...

Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health

Abstract Our Future Health is a prospective study aiming to recruit 5 million UK-resident adults to enable discovery and translation of disease prevention, detection and treatment approaches. So far, more than 2.5 million have enrolled, and baseline phenotypic data are available...

Cross-Platform Evaluation Reveals Sample Preparation-Driven Biological Biases despite Advances in Mass Spectrometry Performance in Serum Proteomics

Abstract Advances in mass spectrometry (MS) instrumentation and protein extraction technologies are reshaping proteomics; however, whether improved analytical performance alters the biological information accessible from different sample preparation strategies remains unclear. He...

A pathway towards decentralized studies of radioactive post-lead elements and their applications in beyond standard model physics

Abstract Molecules have proven to be sensitive tools for studying physics beyond the Standard Model, with heavy and deformed nuclei offering decisive sensitivity to parity- and time-reversal-violating effects. However, almost all elements beyond lead, occupying the 6p to 5f atomi...

Exploring the transcriptional crosstalk between adipose tissue and locoregional recurrence in breast cancer using independent component analysis

Locoregional recurrence (LRR) poses a persistent clinical challenge in breast cancer, with emerging evidence implicating the tumor-associated adipose tissue in modulating recurrence risk. This study investigates shared transcriptional programs between adipose tissue and breast tu...

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

Liking Fast-Food Brands Predicts Poorer Diet Quality, Independent of Perceived Healthiness

Within the theory of planned behavior, ambivalent attitudes (that are simultaneously positive and negative) can weaken the link between attitudes, intentions and behavior. This study examined whether perceived healthiness of fast-food brands would weaken the relationship between...

Gathering input for a mental health intervention based on recovery narratives: a focus group study

Recovery narratives (RNs) could potentially be beneficial for service users, leading to hope and a sense of recognition. It remains understudied how to adequately implement these in mental health treatment. To gather input for the development of a RN intervention, we organized fo...

Coupling ESPResSo and waLBerla for scalable soft matter simulations with hydrodynamic interactions

Many problems in soft matter research involve particles suspended in a solvent, where hydrodynamic interactions play a crucial role. A well-established simulation approach for such systems combines molecular dynamics for the particles with the lattice-Boltzmann method for the sol...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...