Institution
University of Geneva
Recent research
- BiologyOpen access
The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis
Abstract Malaria blood-stage parasites digest ~80% of host cell hemoglobin within a degradative vacuole, releasing heme that is detoxified by sequestration into hemozoin crystals. Although essential for survival and a validated drug target, the mechanisms of heme biomineralizatio...
- Engineering & TechnologyOpen access
Rational Molecular Design to Improve Digital Polymer Readout in Aerolysin‐Based Nanopore Sequencing
ABSTRACT Nanopore sequencing is a promising method for decoding synthetic digital polymers, but translocation signals are often complex. This study examines the influence of macromolecular design on the accuracy of nanopore sequencing. Nine phosphoramidite monomers were synthesiz...
- Climate & EnvironmentOpen access
The Lemba petroleum sub-basin in the western Democratic Republic of the Congo was investigated to assess the composition of soils and riverbed sediments, the concentrations of contaminants and the environmental pollution hazards derived from the ongoing oil exploration and other...
- BiologyOpen access
Abstract High mobility group box protein 1 (HMGB1) is a ubiquitous protein that has multiple functions in the nucleus and cytosol. Following release into the extracellular space, HMGB1 acts as a mediator of inflammation. HMGB1 is overexpressed in many cancers and has both oncogen...
- BiologyOpen access
Autism is a highly heterogenous neurodevelopmental condition that can significantly compromise the quality of life. For children showing atypical trajectories of development in their early years, early and intensive intervention has shown promise in enhancing the development of l...
- Health & Medicine
Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...
- Climate & EnvironmentOpen access
Psychological barriers to improving carbon competence
Abstract To effectively contribute to the mitigation of climate change, individuals require accurate representations of the greenhouse gas emissions related to climate actions across life domains. Although this carbon competence is generally low, the related psychological barrier...
- Health & MedicineOpen access
The prospective longitudinal study compared muscle growth in children with spastic cerebral palsy (CP) with typically developing (TD) peers and across Gross Motor Function Classification System (GMFCS)-groups, and investigated muscle deficit trajectories across GMFCS-groups. Thre...
- Health & MedicineOpen access
Background Dementia is a leading cause of disability and mortality in Europe, yet no recent harmonised assessment has described its impact across the European Union (EU-27) and the WHO European Region. Methods We used data from the Global Burden of Disease Study 2023 (GBD 2023) t...