University of Geneva

Community-Associated Methicillin-Resistant Staphylococcus aureus Among Gay, Bisexual, and Other Men Who Have Sex with Men Living with HIV Who Engage in Chemsex in Barcelona, Spain: Epidemiological Patterns and Implications for Infection Control

Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are increasingly reported among gay, bisexual, and other men who have sex with men (GBMSM) engaging in chemsex, yet data remain limited. This ambispective cohort study conducted at H...

Surgical management and postoperative imaging assessment of hallux valgus

Abstract Hallux valgus (HV) is a common and complex three-dimensional deformity of the first ray, resulting from multifactorial interactions involving anatomical, biomechanical, ligamentous, muscular, and extrinsic factors. The absence of a single etiological mechanism explains t...

The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis

Abstract Malaria blood-stage parasites digest ~80% of host cell hemoglobin within a degradative vacuole, releasing heme that is detoxified by sequestration into hemozoin crystals. Although essential for survival and a validated drug target, the mechanisms of heme biomineralizatio...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...

Rational Molecular Design to Improve Digital Polymer Readout in Aerolysin‐Based Nanopore Sequencing

ABSTRACT Nanopore sequencing is a promising method for decoding synthetic digital polymers, but translocation signals are often complex. This study examines the influence of macromolecular design on the accuracy of nanopore sequencing. Nine phosphoramidite monomers were synthesiz...

HMGB1 expression in CT26 murine cancer cells modulates the tumor microenvironment and limits local anti-tumor immunity

Abstract High mobility group box protein 1 (HMGB1) is a ubiquitous protein that has multiple functions in the nucleus and cytosol. Following release into the extracellular space, HMGB1 acts as a mediator of inflammation. HMGB1 is overexpressed in many cancers and has both oncogen...

Geochemical assessment of metal and REE concentrations in a region with exploration of petroleum resources, Democratic Republic of the Congo

The Lemba petroleum sub-basin in the western Democratic Republic of the Congo was investigated to assess the composition of soils and riverbed sediments, the concentrations of contaminants and the environmental pollution hazards derived from the ongoing oil exploration and other...

Psychological barriers to improving carbon competence

Abstract To effectively contribute to the mitigation of climate change, individuals require accurate representations of the greenhouse gas emissions related to climate actions across life domains. Although this carbon competence is generally low, the related psychological barrier...

Heterogeneity of Response to Early Start Denver Model: Identifying Developmental Trajectories and Predictors of Cognitive Outcomes

Autism is a highly heterogenous neurodevelopmental condition that can significantly compromise the quality of life. For children showing atypical trajectories of development in their early years, early and intensive intervention has shown promise in enhancing the development of l...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Longitudinal characterization of medial gastrocnemius muscle growth deficits throughout childhood in spastic cerebral palsy

The prospective longitudinal study compared muscle growth in children with spastic cerebral palsy (CP) with typically developing (TD) peers and across Gross Motor Function Classification System (GMFCS)-groups, and investigated muscle deficit trajectories across GMFCS-groups. Thre...

Burden of Dementia in Europe, 1990–2023: a systematic analysis from the Global Burden of Disease Study 2023

Background Dementia is a leading cause of disability and mortality in Europe, yet no recent harmonised assessment has described its impact across the European Union (EU-27) and the WHO European Region. Methods We used data from the Global Burden of Disease Study 2023 (GBD 2023) t...