University of Colorado System

Development of a Computational Histology Artificial Intelligence-Powered Prognostic Biomarker in Colorectal Cancer in The Cancer Genome Atlas

Background: Risk stratification in colorectal cancer (CRC) plays an important role in treatment decision-making. As such, prognostic biomarkers that can augment risk stratification have clinical value. Quantitative histologic features from routine hematoxylin and eosin (H&E)-stai...

Reformulating Time-Cure Superposition to Describe the Phase Transition in Rearranging Gel Networks

Abstract Rearranging hydrogels are used for applications that require tailored control of solid- and liquid-like properties. These applications necessitate pinpointing the phase transition, where a sample-spanning structure is formed or broken. To characterize the mechanical prop...

Socioeconomic, psychological distress, and social norm correlates of youth smoking and vaping: a multilevel pooled cross-sectional analysis

Abstract Introduction Cigarette smoking among youth has continued to decline in recent years as vaping product use has become increasingly popular. Lower socioeconomic status (SES), psychological distress, and exposure to more permissive smoking norms are associated with higher r...

Semantic Impedance Matching in Multi-Agent Language Model Pipelines: Measuring, predicting, and correcting information loss at agent boundaries

When a signal crosses a boundary between transmission media of mismatched impedance, part of it reflects and transmitted power is lost, the phenomenon the Smith Chart was created to tame in 1936. This study tests whether an analogous framework describes information loss when cont...

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function

Abstract Background Protein quality control (PQC) is critical for maintaining sarcomere structure and function in cardiac myocytes, and mutations in PQC pathway proteins, such as CRYAB (arginine to glycine at position 120, R120G) and BAG3 (proline to lysine at position 209, P209L...

How Much is Too Much? Examining the Ethical Boundaries of Exposure from Production to Editing in Photojournalism

This study seeks to examine the perceptions of practitioners in the field of photojournalism regarding ethical exposure in photojournalism in both the production and editing phases. The ethical considerations range from exposing for the highlight, or the brightest part of a frame...

Distance-spectral classification of twelve-point kissing shells in three dimensions

Let D={1,2,8/3,3,11/3,4}, the set of squared distances realised between two points of one twelve-neighbour shell of a Barlow (close-packed) structure. Call a twelve-point subset of the unit sphere distance-spectral if all of its pairwise squared distances lie in D. We prove that...

Distance-spectral classification of twelve-point kissing shells in three dimensions

Let D={1,2,8/3,3,11/3,4}, the set of squared distances realised between two points of one twelve-neighbour shell of a Barlow (close-packed) structure. Call a twelve-point subset of the unit sphere distance-spectral if all of its pairwise squared distances lie in D. We prove that...

Streamlining analysis and design of two-dimensional electronic spectroscopy using machine learning

Two-dimensional electronic spectroscopy (2DES) offers unique insights into the coupling between electronic and nuclear motion and dynamics, making it a key technique in diverse fields, including materials science and biology. Obtaining 2DES data requires a series of measurements...

Aggregation behavior and intraspecific interactions among ring-necked snakes

Sociality, broadly defined as the property or tendency of a species to live in groups with conspecifics for at least part of their life cycle, has convergently evolved multiple times. While there has historically been a dearth of research on sociality in squamate reptiles, recent...

What Should We Listen for in Social Studies Discussions?

Built around four social studies-specific dimensions—content, source scrutiny, empathic imagination, and ethical action—the Social Studies Discourse Instrument gives teachers a fresh, nonevaluative lens on classroom discussion.

Module for Event-Driven Operations on Spacecraft (MEDOS)

The Module for Event-Driven Operations on Spacecraft (MEDOS) is a framework for making real-time operational decisions based on detected events from onboard measurements. MEDOS calculates derived parameters, which are physically meaningful and relevant to a mission planner. MEDOS...

Vibrational Spectraof Anionic Polycyclic AromaticHydrocarbons in the CH Stretching Region: Anthracene, Pyrene, Perylene,and Fluoranthene

Abstract The CH stretching region of the infrared spectra of polycyclic aromatic hydrocarbon radical anions (2700–3100 cm–1) is characterized by complicated band patterns that defy straightforward assignments from harmonic calculations. We compare experimental infrared photodisso...

From Posts to Perceptions: How Reddit Users Feel About Phalloplasty and Metoidioplasty

Abstract Gender-affirming surgery, including phalloplasty and metoidioplasty, has demonstrated efficacy in alleviating gender dysphoria in appropriately selected patients. This study aims to better describe the needs and priorities of patients undergoing these procedures by using...

Understandingthe Electronic Structure of RutheniumOxides during Redox Cycling with High Energy Resolution X-rayAbsorption Spectroscopy

Abstract Ruthenium oxides are essential catalysts and charge storage materials whose performance across reactions, from the oxygen evolution reaction to the chlor-alkali process, depends critically on reversible Ru redox cycling and the associated electronic structure changes. Al...

Longitudinal changes in gut microbiota across reproductive states in wild baboons

Background: In humans and other mammals, female reproduction is linked to extensive changes in physiology, immunity, hormones, and behavior. These changes likely shape, and may be shaped by, the composition of gut microbial communities. Characterizing the dynamics of gut microbia...

Regional FireworksPollution over East and SoutheastAsia from Airborne Observations around the Spring Festival Period

Abstract Fireworks are spectacular, but they also pollute the atmosphere. While fireworks are known to rapidly increase local pollution levels, the regional influences and nanosized appearance of fireworks-related particles are poorly understood. This study collected aerosol part...

Trions as Fundamental Species in Chemically Doped Polymer Semiconductors

Doping is a cornerstone strategy for enhancing charge transport in semiconducting polymers, important for their application in, for example, semi-transparent electrode materials, thermoelectric devices, and antistatic coatings. Both chemical and electrochemical doping have, for t...

How AI induces professional identity threats: A survey study with public relations professionals

The transformative force of AI is largely redefining how public relations professionals approach their work, understand their responsibilities, and make sense of the meaning and value associated with being a PR practitioner. While research in other disciplines have increasingly r...

The Fertility Reduction Effects of the Colorado Family Planning Initiative by Age and Parity

ABSTRACT We use restricted‐access birth records from the National Vital Statistics System (NVSS) to document the full age and parity fertility effects of the Colorado Family Planning Initiative (CFPI). The CFPI provided access to every FDA approved method of contraception for fre...