University of Cincinnati Medical Center

Clinical characteristics and outcome of a cohort of CLL patients with BTK T474 gatekeeper mutation

BTK T474 gatekeeper mutations confer resistance to both commercially approved covalent and non-covalent BTK inhibitors (BTKis) in chronic lymphocytic leukemia (CLL), yet their clinical implications remain poorly characterized. While pirtobrutinib was developed to overcome resista...

A scoping literature review of factors associated with burnout among student pharmacists in the United States

Objectives Burnout is an increasing challenge among student pharmacists. Individual studies have examined burnout among student pharmacists; however, faculty and college administrators lack a consolidated understanding of the educational, personal, and contextual factors associat...

A self‐retaining mouth prop for intraoral access during periodontal surgery in rat models: A technical note

Abstract Background Rodent models are widely used in oral health research; however, maintaining stable and effective intraoral retraction in the small oral cavity is challenging. Manual retraction methods often lead to procedural instability, operator fatigue, and increased tissu...

Glucocorticoid exposure disrupts vascular-immune interactions and impairs steroidogenesis in the fetal mouse testis

Abstract Antenatal corticosteroid (ACS) therapy, typically using dexamethasone (Dex), is a cornerstone of improving preterm infant survival by accelerating lung maturation. However, its systemic effects on other developing organs remain poorly understood. Here, we reveal a previo...

Understanding Remote Monitoring within an Outpatient Setting

Date presented: April 25, 2026 Primary Author and Speaker: Kelly M. Farrell, kelly.farrell2@cchmc.org

Analysis of brain iron deposition in an in vivo model of pediatric autosomal dominant polycystic kidney disease

Polycystic kidney disease (PKD) represents one form of chronic kidney disease (CKD) affecting the pediatric population. CKD in early life has been associated with neurocognitive deficits and disturbances in iron metabolism. Excess iron accumulation may exacerbate inflammatory and...

Occupational and Environmental Hazards in Pediatric Home Healthcare: A Cross-Sectional Study

Background: Home healthcare workers (HHCWs) face challenges related to hazard exposure and disease prevention. The Home Healthcare Environmental Assessment Survey (HHEAS) was developed as a mobile-friendly version of the Home Healthcare Observation tool (HHCWO) to assess occupati...

Comparison of prenatal self-report of tobacco use to direct measurement of umbilical cord cotinine

Abstract Objective This study compared maternal self-reports of prenatal tobacco product use with biochemically confirmed cotinine in umbilical cord tissue in newborns exposed to opioids in utero and unexposed controls. Study design Secondary data analysis on 179 pregnant women a...

Impact of SGA, AGA, and LGA birthweight subclassification on NICU mortality risk identification: a cohort study

Abstract Objective To assess whether subdividing small (SGA, <10th), appropriate (AGA, 10th–90th), and large (LGA, >90th percentile) for gestational age (GA) birthweight classifications improves mortality risk estimation among preterm infants in neonatal intensive care units (NIC...

From timekeeping to divisions—Molecular links between circadian rhythms and cell cycle

Circadian rhythms and the cell cycle are two fundamental biological oscillators. They are linked through molecular mechanisms creating coupled oscillators where the outcomes of this coupling depend on numerous factors, such as the directionality of coupling (i.e., unidirectional...

Long-Term Follow-Up of Checkpoint Inhibitor-Associated Uveitis Treated with Fluocinolone Acetonide Intravitreal Implant in a Pediatric Patient

Purpose To describe the clinical course and 2-year follow-up of a pediatric patient treated with 0.18 mg fluocinolone acetonide intravitreal implants (Yutiq, EyePoint Pharmaceuticals) for chronic, bilateral immune checkpoint inhibitor (ICI)-associated uveitis.Methods Retrospectiv...

Trends in Regionalization of Pediatric Inpatient and Critical Care by Medical Complexity

BACKGROUND AND OBJECTIVES: Pediatric inpatient and critical care services are increasingly regionalizing: shifting from smaller hospitals to larger specialty centers. Children with medical complexity (CMC) and with technology dependence (TD) account for a disproportionate share o...

Spinal interoceptive pathways as therapeutic targets in depression

Interoception is commonly defined as the process by which the nervous system senses, interprets and integrates signals from the body. Converging theoretical frameworks propose that signals about bodily states are conveyed by spinal interoceptive pathways (SIPs) to a distributed i...

Fundamentals of Arthroscopic Surgery Training Program Shows Transfer Validity Through Enhanced Operative Arthroscopic Performance

PURPOSE: To evaluate the content, construct, concurrent, and transfer validity of the Fundamentals of Arthroscopic Surgery Training (FAST) program and to determine whether FAST testing performance correlated with arthroscopic performance in the operating room. METHODS: Participan...

Training imaging professionals on transgender-inclusive breast cancer screening practices

Abstract Purpose Transgender/gender diverse (TGD) people are underscreened for breast cancer. A barrier to screening is anticipated discrimination during screening encounters. This pilot study evaluates a training session for breast imaging professionals (clinical support special...

Moebius‐Plus Phenotype With Positive RCEM Episignature May Indicate Broader Embryologic Malformation Spectrum Detectable by Methylation Profiling

ABSTRACT Moebius syndrome (OMIM #157900) is a rare congenital cranial dysinnervation disorder characterized by abducens (CN VI) and facial (CN VII) nerve palsies with variable craniofacial and limb anomalies. Despite advances in genomic testing, the majority of patients remain ge...

Interplay between fibroblast growth factor 9 (FGF9) and CD44 underlies 46,XY disorders of sex development in Kruppel‐like factor 1 (KLF‐1)‐E325K‐associated congenital dyserythropoietic anaemia (CDA‐IV)

Summary A heterozygous Kruppel‐like factor 1 (KLF1) E325K mutation causes a severe form of congenital dyserythropoietic anaemia (CDA), designated CDA‐IV (Online Mendelian Inheritence in Man, OMIM 613673), a rare disease with only 15 cases known. In addition to haemolytic anaemia,...

A County-Level Collaboration to Reduce Infant Mortality: Cradle Cincinnati

OBJECTIVE: We sought to implement and determine the efficacy of Cradle Cincinnati-a county-level collective impact collaborative established to reduce the infant mortality rate (IMR) of Hamilton County, Ohio. We hypothesized that the reduction in the IMR of Hamilton County was at...

Response to Vibration‐controlled transient elastography in pediatric metabolic dysfunction‐associated steatotic liver disease: Considerations for risk stratification and clinical use

The authors declare no conflict of interest. Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

In Situ Multiscale Imaging Reveals Cellular Selection and Remodeling of Peptide Assemblies from Membrane Perturbation to Actin Dysregulation

Abstract Enzyme-responsive peptide nanomaterials can induce non-apoptotic cancer cell death, yet the supramolecular states that mediate activity in cellular environments are usually inferred rather than directly resolved. Here, we integrate multiscale in situ imaging with biochem...