University of Chieti-Pescara

Transoral robotic versus laser surgery for cT1-T3 supraglottic laryngeal cancers: a systematic review and meta-analysis of comparative and non-comparative studies

Background To compare literature findings about functional, oncological and surgical outcomes of transoral robotic (TORS) versus transoral laser microsurgery (TOLM) for supraglottic cT1-T3 laryngeal cancers. Methods Three independent investigators conducted a PubMed, Scopus, and...

Molecular evolution of oxygenated organic molecules in a cloud-influenced forested mountain environment

Abstract. Atmospheric oxygenated organic molecules (OOMs) link the oxidation of volatile organic compound to secondary organic aerosol formation, yet their molecular evolution in cloud-influenced forested mountain environments remains poorly constrained. Here, gas-phase OOMs were...

A Model of Digital Socialisation

Focusing on the portability revolution, this theoretical paper explores how smart devices and their associated visual and algorithm-driven social networks have become highly impactful socialisation agencies, especially for youth. Integrating secondary data with various mass commu...

Bilateral Internal Thoracic Artery Grafting in Coronary Surgery: A Three-Tier Decision Framework

The left internal mammary artery grafted to the left anterior descending artery (LAD) is the main determinant of survival in coronary artery bypass grafting, but the choice of the second graft remains controversial. The use of both mammary arteries offers a greater long-term surv...

ACTN3 Variants Beyond Performance: Metabolic and Inflammatory Implications

Background: Athletic performance is a result of interaction between genetic and environmental factors, including training, nutrition, rest, hormonal and psychophysiological status. Numerous genes and polymorphisms can influence key physiological processes, such as muscle contract...

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Comparative Biomechanical Evaluation of SDS and Nobel Ceramic Dental Implant Systems in Type II Artificial Bone: An In Vitro Study

Ceramic dental implants have been proposed as metal-free alternatives to titanium implants. This in vitro study compared the biomechanical measurements and drilling-related surface temperatures of two commercial ceramic implant systems with different dimensions and drilling proto...

Die Panne by Friedrich Dürrenmatt: A Trial for the Concept of Justice

This essay critically examines Friedrich Dürrenmatt’s Die Panne as a profound metaphor for the complexities and perversions of justice in modern society. Dürrenmatt constructs a narrative that subverts traditional detective story conventions, presenting a reverse trial in which t...

Detection of Cytomegalovirus in Chorionic Villi for the Prenatal Diagnosis of Congenital Infection: A Systematic Review of Diagnostic Test Accuracy

Background and Objectives: Congenital cytomegalovirus (CMV) infection following primary maternal infection in the first trimester carries the highest risk of long-term sequelae, yet prenatal diagnosis depends on amniotic fluid polymerase chain reaction (PCR), which cannot be perf...

The robotic PIANO: a critical narrative review of surgeon-controlled operative polyphony, human factors, and robotic training

Abstract Robotic surgery can concentrate control of several technical functions at the console, but such concentration does not itself confer clinical independence, reduce dependence on the perioperative team, or improve patient outcomes. We define surgeon-controlled operative po...

Conservative Management of Pediatric Mandibular Condylar Fractures: A Systematic Review

ABSTRACT Mandibular condylar fractures are common mandibular injuries in children. Conservative treatment is generally favored because of the remodeling capacity of the growing condyle, although rehabilitation protocols and the criteria for operative treatment remain variable. Th...

Everything you always wanted to know about sleep, but you were afraid to ask: expert concise guide and recommendations on assessing sleep-wake disturbances within a psychiatric context in contemporary times

OBJECTIVE: While disrupted sleep has long been linked to mental disorders there has been a notable decrease in interest and sleep-wake disorders have received low priority in psychiatric care. The aim of the paper was to present a concise guide for evaluating common sleep-wake di...

Anticancer Drugs and Cancer-Associated Thrombosis

The rapid development of novel cancer therapies has considerably improved the care of cancer patients and cancer-related survival; however, these therapies are associated with a broad range of adverse events that have become a major burden in this population. Alongside other canc...

The lived experience of trans persons: a bottom-up review co-written by experts by experience and academics.

We present here the first bottom-up review of the lived experience of trans persons, co-written by experts by experience and academics. We sourced the medical and non-medical literature, focusing on first-person narratives, and critically extracted experiential themes, which were...

Bedside HST and SVINT as Clinical Indicators Associated with Caloric DP and UW: A Retrospective Exploratory Study

Background: Caloric testing provides quantitative measures of unilateral weakness (UW) and directional preponderance (DP). By contrast, skull vibration-induced nystagmus (SVINT) and the head-shaking test (HST) are bedside procedures that use different stimuli and operate within d...

Postpandemic Trends in Pediatric Respiratory Virus Hospitalizations: A Multicenter Study, 2019–2025

ABSTRACT Background The COVID‐19 pandemic profoundly altered the circulation of respiratory viruses in children, changing the epidemiology of acute lower respiratory tract infections. In the postpandemic period, respiratory pathogens showed marked temporal variability. The 2024–2...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Graphene Oxide and Methylglyoxal: a combined strategy against chronic wound pathogens

Abstract Chronic wound infections are difficult to treat due to the polymicrobial biofilms that delay wound healing increasing antimicrobial tolerance and limiting patient compliance. To address this challenge, we developed a non-antibiotic combination of Graphene Oxide (GO) and...

Centre–periphery income bipolarization in Italy: evidence from municipal fiscal data, 2015–2022

Abstract This paper examines income bipolarization and inequality across Italian municipalities, focusing on the distributional divergence between urban centres and inner (peripheral) areas over the period 2015–2022. Using municipal-level fiscal declaration data from the Italian...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...