University of Chieti-Pescara

Differential homeostatic reorganization during high-altitude trekking: multisystemic adaptations and organ-specific resilience

Abstract Introduction High-altitude exposure combined with physical activity triggers complex systemic adaptations. However, multidisciplinary longitudinal investigations into these multiorgan responses remain limited. This prospective observational study aimed to investigate the...

Antidiabetic medications and arterial thrombotic risk reduction: a narrative review

Abstract Diabetes mellitus is associated with a persistent prothrombotic state driven by platelet hyperreactivity, endothelial dysfunction, oxidative stress, and chronic low‑grade inflammation, all of which contribute to increased cardiovascular (CV) risk. Importantly, a substant...

Multiscale network reorganization during the multidimensional recollection of naturalistic events

Abstract The recollection of complex events is multidimensional. Recent work has gathered evidence for varying degrees of functional specialization for different memory dimensions across the main cortical networks involved in cued recollection. However, how functional brain netwo...

Antiarrhythmic Drug Therapy in Cardiomyopathies: A Comparative Synthesis of Guidelines and Consensus Documents

Abstract Purpose of Review Antiarrhythmic drug therapy in cardiomyopathies remains challenging because arrhythmic risk, drug efficacy, and pro-arrhythmic vulnerability vary substantially across phenotypes. This review summarizes contemporary guideline and consensus recommendation...

The IO PhD International Research Program 15 years later: where do we stand?

Abstract Background International doctoral research programs represent an effective model for fostering scientific collaboration and training clinician-scientists. The Italia-Olanda PhD International Research Program (IO PhD), established in 2010, was designed to promote translat...

Effectiveness of oxidative therapies in mature oral biofilms: A systematic review and meta-analysis

To evaluate the antimicrobial activity of oxidative therapies in disrupting and reducing mature oral biofilms (≥ 48 h) and to assess treatment effects across different oxidative modalities. A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. Twe...

Lung Ultrasound in Bronchopulmonary Dysplasia: Diagnostic Tool, Prognostic Marker or Monitoring Strategy?

Bronchopulmonary dysplasia (BPD) remains one of the leading chronic respiratory complications of extreme prematurity despite major advances in neonatal intensive care. Current diagnostic definitions are primarily based on respiratory support requirements and provide limited infor...

Comparative cytoarchitectural and proteomic analysis of the primary motor cortex in pigs and wild boars reveals domestication associated changes

Background Domestication appears to modify the morphology and physiology of the central nervous system. Owing to the limited availability of proteomic and cytoarchitectural data for comparisons between wild and domesticated species, we conducted a comparative analysis of the cyto...

Pyrroloquinoline Quinone and NAD+ Metabolism in Glaucoma: A Molecular Rationale for Combined Neuroprotection

Glaucoma is the leading cause of irreversible blindness worldwide and a paradigmatic age-related neurodegenerative disease in which retinal ganglion cells (RGCs) are selectively lost through mechanisms that extend beyond intraocular pressure. Age-dependent NAD+ depletion in RGCs,...

Perineal Care Strategies and Perineal Outcomes in Primiparous Women: A Prospective Observational Pilot Study

Background: Pregnancy and childbirth expose the pelvic floor and perineal tissues to substantial biomechanical stress, increasing the risk of obstetric perineal trauma and subsequent maternal morbidity. Objectives: This prospective observational pilot study aimed to explore the a...

Virtual Reality for the Assessment of Visual Capacities: A Systematic Review

Objectives: Virtual reality (VR) enables controlled, interactive, and ecologically valid visual tasks, offering potential advantages over static clinical tests. This systematic review synthesized current evidence on the use of VR technologies for assessing visual capacities acros...

Phacoemulsification surgery: stepping into the mixed reality era

PURPOSE: To test the applicability of a mixed reality headset in cataract surgery. METHODS: Patients scheduled for phacoemulsification and intraocular lens implantation surgery were enrolled in our prospective interventional study. All patients underwent complete baseline ophthal...

Potential Anticancer Activity of Donkey Milk in Human Gastric Adenocarcinoma (AGS) Cell Line

Gastric cancer (GC) remains a major global health challenge, ranking among the most lethal malignancies due to late diagnosis, high tumor heterogeneity, and limited treatment efficacy. The search for safer, nutritionally based adjuncts to conventional therapies is therefore a res...

Semi-supervised evaluation of University quality: from structured measures to student voices

Abstract Understanding student satisfaction in higher education requires more than standardized survey scores alone. While structured survey responses provide standardized and comparable measures of satisfaction, they often fail to capture the heterogeneity of students’ experienc...

Quantitative Evaluation of Geographic Atrophy Progression Using Geographic Atrophy Lesion Front Displacement

Purpose: To evaluate the temporal behavior and relative variability of a margin-based metric, lesion front displacement, for quantifying geographic atrophy (GA) progression secondary to age-related macular degeneration and to compare its performance with conventional metrics. Met...