University of California System

Recruitment and Engagement in Care to Impact Practice Enhancement for Patients with Sickle Cell Disease: Study Protocol

Abstract Objectives To adapt an evidence-based linkage coordinator model used in HIV care to identify, engage, and link adults with sickle cell disease (SCD) who are unaffiliated from specialty care to SCD specialists, and to assess implementation readiness, processes, outcomes,...

Fatty Acid and Oxylipin Metabolism Differentiate Isolated Postcapillary From Combined Pre- and Postcapillary Pulmonary Hypertension

BACKGROUND: Pulmonary hypertension (PH) due to left-sided heart disease (Group 2 PH) is the most common type of PH and comprises 2 subtypes with distinct clinical profiles and outcomes: isolated postcapillary PH and combined pre- and postcapillary PH (Cpc-PH). Bioactive lipid der...

HIV and anticholinergic burden: Towards a pragmatic stewardship algorithm

Abstract Background Multimorbidity and polypharmacy increase exposure to medications with anticholinergic properties in people with HIV. In elderly people, higher anticholinergic burden (ACB) is linked to cognitive impairment, falls, functional decline and mortality, whose risk i...

Cu-Catalyzed Funneling Oxidation Enables C–C Bond Cleavage in Lignin-derived Compounds

Abstract The structural complexity and chemical heterogeneity of lignin present a formidable barrier to its use as a sustainable replacement for petroleum-derived aromatics. Here, we report a robust, earth-abundant copper/nitroxyl catalytic system that achieves the aerobic oxidat...

Single‐cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti‐SSA antibodies and aberrant B cell populations

OBJECTIVES: Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes. The objective o...

MIR192 upregulates GLP-1 receptor and rescues statin-induced impairment of insulin secretion

Abstract Background Statins are a commonly prescribed cholesterol-lowering drug class that can increase the risk of new-onset diabetes (NOD). The underlying molecular mechanisms have yet to be fully elucidated. We aimed to identify molecular factors associated with differential s...

Through the Eyes of Psychiatrists: Mental Health Services in Iraq– A Qualitative Study

Background: Iraq has considerable challenges in delivering mental health services. The country has been in years of conflict and war. These events have taken a severe toll on the mental health of its people. Aims: This study aimed to explore psychiatrists' views on public mental...

A stakeholder-engaged process to design and implement the Assessment of Cognitive Complaints Toolkit for Alzheimer’s Disease (ACCT-AD) in primary care

Background: Dementia is underdiagnosed, particularly in primary care settings where most people receive their healthcare. These is a need for tools to assist with the diagnosis of dementia by primary care clinicians, who greatly outnumber specialists. Objective: To describe the c...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

Quantum Light Spectroscopy

Abstract Spectroscopy based on individual-photon-level light sources brings new variables to both spectroscopy and imaging. We refer to this approach as quantum-light spectroscopy (QLS). The photon statistics of different types of photon sources and photon entanglements are brief...

Metagenome-scale modeling to assess microbiome metabolic complementarity for precision microbiota transplantation therapies

Fecal microbiota transplantation (FMT) holds therapeutic promise beyond recurrent Clostridioides difficile infection, but clinical outcomes remain unpredictable, in part because existing computational models do not fully capture the metabolic compatibility between donor and recip...

Centrifuge Modeling of Variable-Rate Cone Penetration Testing in Fly Ash and Its Implications for State Interpretation

Abstract Analysis of cone penetration tests (CPTs) typically is used to assess the stability of waste storage facilities (WSFs) to prevent failures. Materials in WSFs, such as fly ash, often contain a significant proportion of silt-sized particles, making them susceptible to part...

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

ABSTRACT Synaptic dysfunction is a major driver of cognitive decline in Alzheimer's disease (AD), yet its extent and molecular basis in the retina remain poorly defined. We integrated postmortem retinal and matched brain histopathology with ultrastructural, proteomic, biochemical...

Understanding the Research Needs and Educational Methods of Surgeons to Help Guide Future Spine Deformity Research: A Survey of AO Spine Members

Study Design Cross-sectional survey. Objective Outcomes research has significantly shaped patient management in spine deformity care, while the dissemination of research remains a challenge. To guide future research directions, this study surveyed AO Spine members to identify the...

The importance of classifying central hypopneas: a call to action

Obstructive and central sleep apnea share pathophysiologic features and often coexist within individual patients. There is general agreement on the criteria for scoring obstructive and central apneas but less guidance and clarity on how and when to classify obstructive and centra...

Proteomic Immune Signatures of Severe HIV-Associated Tuberculosis in Sub-Saharan Africa: A Prospective, Multicenter Analysis From Uganda

Abstract Objective Severe tuberculosis (TB) is a major cause of critical illness and death in people living with HIV (PLWH) worldwide. Despite this, the immunopathology of severe HIV-associated TB (HIV/TB) is poorly understood. We aimed to identify an immunopathologic signature o...

Effect of electron cyclotron waves on plasma with runaway electrons

Abstract Runaway electrons generated during tokamak disruptions are a major concern for the safe operation of future fusion devices. The interaction of runaway electrons with waves has been proposed as a potential mechanism for their mitigation. This study investigates the effect...

The Pediatric Hospitalist: A Survey of What We Do and Where We Are Going

BACKGROUND: Pediatric hospital medicine (PHM) is undergoing structural transitions, including the discontinuation of the practice pathway to board certification and changes to pediatric resident training, decreasing inpatient exposure. In this context, understanding the compositi...

The Pediatric Hospitalist: A Survey of How We Are Doing

Physician well-being has important implications for clinicians, patients, and health care organizations. Burnout not only takes a human toll but is also associated with reduction in work hours, attrition, and medical errors.1 Conversely, career satisfaction is linked to improved...

LinkLlama: Enablinga Large Language Model for ChemicallyReasonable Linker Design

Fragment-based drug discovery (FBDD) relies heavily on the design of chemically viable linkers to connect fragments binding to different pocket regions into potent lead molecules. While recent generative models have advanced spatial fragment linking, they frequently produce linke...