University of California System

Evaluating large language model performance in US FDA regulatory science

Abstract Background Clinical and population decision-making relies on the systematic evaluation of extensive regulatory evidence. The FDA drug reviews provide detailed information on clinical trial design, enrollment criteria, sample size, randomization, comparators, endpoints, a...

ON THE BOUNDEDNESS OF SINGULARITIES VIA NORMALIZED VOLUME

Abstract In this article we study conjectures regarding normalized volume and boundedness of singularities. We focus on singularities with a torus action of complexity <mml:math xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mnf="http://cambridge.org/core/manifest" xmlns:cup="h...

Wh -questions and predication in Mayan

Abstract This paper examines the syntax of quantificational expressions in Chuj, a Mayan language spoken primarily in Guatemala and Mexico. Building on Royer, Buenrostro &amp; Jenks (2026), we argue that Chuj quantifiers fall into two distinct syntactic categories. Some quantifie...

Improving sepsis best practice utility and clinical acceptance using an LLM-enhanced prediction system

Early detection of sepsis is essential for reducing mortality, but diagnosis can be delayed because symptoms of sepsis are often non-specific, frequently mimic other conditions and differ between individuals. We implemented COMPOSER-LLM, an enhanced sepsis prediction system that...

Deciphering Kinetic Principles of Dual‐Anion Electrolytes for Extreme Fast‐Charging Lithium‐Ion Batteries

ABSTRACT Tailoring Li + solvation coordination has been recognized as a strategy to enhance the electrochemical performance of lithium‐ion batteries (LIBs) under extreme fast‐charging (XFC) conditions. Beyond weakening Li + solvation, increased Li–anion pairing plays a crucial ro...

Why now, why here: a conjunctural theory of socialist advance in big city America

Socialist electoral formations are advancing in large, knowledge-economy American cities while remaining absent from more peripheral economic spaces, and now, rather than two decades ago, when inequality and labor militancy were arguably more acute. This paper explains that uneve...

Exploring Middle and High School Personnel’s Definition and Knowledge of Evidence-Based Practices for Autistic Students

Background Mandates that educators use evidence-based practices (EBP) with autistic students have not led to their widespread or consistent implementation, despite their growing availability. EBP knowledge is integral to effective implementation, and prior studies have shown that...

NEW INC Y12 Creative Science: A Longitudinal Art–Science Study of the Microbiota–Gut–Brain Axis

RationaleDespite growing recognition that emotion is shaped by the whole body, research models have remained largely brain-centric, overlooking microbial and biochemical systems in the gut.The microbiota-gut-brain axis (MGBA) represents one such underexplored layer: gut microbes...