University of California System

LinkLlama: Enablinga Large Language Model for ChemicallyReasonable Linker Design

Fragment-based drug discovery (FBDD) relies heavily on the design of chemically viable linkers to connect fragments binding to different pocket regions into potent lead molecules. While recent generative models have advanced spatial fragment linking, they frequently produce linke...

Isothermal Captureand Release of Carbon Dioxide witha Porous Molecular Hexaamine

Abstract The decarbonization of fossil fuel combustion streams and air is imperative to achieve negative carbon emissions and requires discovery of new materials that exhibit high CO2 capacities, long-term stability, and minimal energy input for the release of pure CO2. Numerous...

The Star Formation History and Evolution of the Ultra-Diffuse M81 Satellite F8D1

Abstract We present deep Hubble Space Telescope (HST) imaging of one of the nearest ultra-diffuse galaxies (UDGs) outside of the Local Group: F8D1, a satellite of M81 known to be tidally disrupting. UDGs are an enigmatic and diverse population, with evolutionary pathways ranging...

Ventral cervical epidural electrical stimulation failed to increase respiratory activity in anesthetized humans during opioid-induced respiratory depression

Respiratory depression is the leading cause of death during opioid overdoses. Epidural electrical stimulation (EES) may facilitate rhythmic motor activities such as locomotion and respiration. We investigated whether tonic, submotor threshold, EES of the ventral cervical spinal c...

Leveragingthe Gut Microbiota for MechanisticallyInformed Therapeutics against Body-First Parkinson’s Disease

Abstract Although some symptoms of Parkinson’s disease can be pharmacologically alleviated, stopping disease progression is not currently possible. Motor impairment in Parkinson’s disease is associated with accumulation of aggregates of the protein α-synuclein (α-syn) in dopamine...

A Tutorialon Automated Mass Spectral Analysis Using NucleoSpec for Compositional Assignment of Nucleic Acid-SilverComplexes and Nanoclusters

Abstract Nucleic acid–metal complexes, such as DNA-stabilized silver nanoclusters (DNA-AgN) and Ag(I)-mediated DNA duplexes, show promise for applications ranging from biomedical imaging to bioelectronics and sensing. Electrospray ionization mass spectrometry (ESI-MS) is a powerf...

Regulation of DiverseEndogenous Metabolic and SignalingPathways by UDP-Glucuronosyltransferases (UGTs) Revealed by Metabolomicsof Knockout Mice

Abstract Uridine 5′-diphospho-glucuronosyltransferase (UGT) enzymes play a critical role in hepatic and other metabolism of endogenous and exogenous small molecules. The addition of glucuronic acid via UGT increases the polarity and subsequent solubility of small molecules, helpi...

Bayesian Nonlinear Structural Model Parameter Updating Using Visual Damage Indicators

Abstract Postearthquake decisions regarding the repair, retrofit, and safety of damaged infrastructure often rely on accurate estimates of structural response demands. These estimates are highly sensitive to uncertain material parameters whose true values often deviate from those...

Infrastructure-Led Tourism Development and Residents’ Quality of Life: The Mediating Role of Place Image in an Emerging Heritage Destination

While tourism infrastructure is crucial to regional development, its impact on resident well-being is still debated. This study investigates the influence of infrastructure on material and non-material quality of life, utilizing place image as a mediation, and grounded on the Tou...

Electron Shot Noise on a Current Biased Antenna

Abstract The Parker Solar Probe (PSP) Fields Experiment (FIELDS) uses Radio Frequency Spectrometer (RFS) data and Quasi‐Thermal Noise Spectroscopy (QTN) to determine the temperature and density of electrons in the heliosphere. The FIELDS antennas typically operate with a negative...

Quantitative analysis of binocular alignment by Hess screen testing in surgery for superior oblique palsy

Background/Aims: Conventional prism-cover strabismus measurement is compromised by nonstandard and poorly repeatable target locations. We developed a general method to quantify incomitant strabismus in repeatable, defined gazes and illustrate its application to commonly performed...

DESI Strong Lens Foundry. IV. Spectroscopic Confirmation of DESI Lens Candidates with VLT/MUSE

Abstract We present integral field spectroscopic observations of 76 strong gravitational lens candidates identified with a residual neural network in the DESI Legacy Imaging Surveys, obtained with the Multi Unit Spectroscopic Explorer (MUSE) on ESO’s Very Large Telescope. These o...

Threomer Inhibition of S1−ACE2 Binding

Abstract The interaction between the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S1) and human ACE2 receptor is essential for viral entry into host epithelial cells and a key target for drug discovery. Here, we describe the evolution of a threomer, a base-modif...

Lipids in endothelial-to-mesenchymal transition

Purpose of review Endothelial-to-mesenchymal transition (EndMT) has been implicated in the development of cardiovascular disease, including atherosclerosis. EndMT is a complex continuum with multiple involved pathways, each with different pathophysiologic implications depending o...

Learning to be inaccurate like an adult: Using computational cognitive modeling to investigate the acquisition of pronoun interpretation in Spanish

Abstract When children behave differently from adults in language tasks, it is often unclear if the underlying cause is non-adult-like representation of relevant information, non-adult-like deployment of adult-like representations, or both non-adult-like representations and non-a...

Source to Site: Geochemical Analysis of Obsidian Artifacts from Three Maya Sites in the Southeastern Three Rivers Adaptive Region, Belize

Abstract Linking obsidian artifacts to their original sources elucidates ancient Maya trade networks and examining changes in the frequency of source attribution through time highlights shifting social, political, and economic affiliations. This report presents geochemical data f...

Brains, Networks and Dynamics

Abstract This paper argues that when brain networks figure in explanations of cognition and behavior they often do so in conjunction with independent dynamical assumptions about signal transmission in the brain. In such cases explanation does not depend on network structure alone...

Daily Provisions: Tracing a Longue Durée of Feeding Archaeological Workers and Paths of Sustenance for the Future

Abstract Providing sustenance for archaeological workers has been a logistical and social challenge from the earliest stages of the discipline. Food preparation involved a constellation of workers, from gardeners to ingredient purchasers, and from cooks and chefs, who were often...

Electrostatically Limited PFSA Ionomer Adsorption to Catalyst Particles in Catalyst Inks

Abstract Understanding and controlling ionomer adsorption in catalyst inks is critical to optimizing catalyst-layer structure and performance in membrane-electrode assemblies. Here, we systematically quantify perfluorosulfonic-acid (PFSA) ionomer adsorption across a diverse set o...

Catalyst Control of Alkylbenzene Molecular Architecture in Tandem Catalytic Hydrogenolysis-Aromatization of Polyethylene

Abstract Upcycling of polyethylene (PE) can transform waste material into chemically valuable building blocks such as linear alkylbenzenes, with potential use in anionic surfactants. Alkylbenzenes can be formed by tandem hydrogenolysis-aromatization of PE, catalyzed by Pt nanopar...