University of British Columbia

Development and Initial Validation of an Expressive Vocabulary Test for Movement Concepts and Skills in Adults with Down syndrome

The present study aimed to develop and psychometrically evaluate the Expressive Vocabulary Test - Movement Concepts Skills - Down syndrome (EVT-MCS-DS) and to examine possible differences in expressive vocabulary performance according to demographic characteristics, including sex...

Deletion of protein tyrosine phosphatase 1B in hepatocytes attenuates inflammation, steatosis, and fibrosis in a dietary mouse model of metabolic dysfunction-associated steatohepatitis

Abstract Background Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver-related morbidity and mortality. The current interventions are limited, underscoring the need for novel mechanism-based therapies. Protein tyrosine phosphatase 1B (PTP1B) regul...

Wasserstein mirror gradient flow as the limit of the Sinkhorn algorithm

We prove that the sequence of marginals obtained from the iterations of the Sinkhorn algorithm or the iterative proportional fitting procedure (IPFP) on joint densities, converges to an absolutely continuous curve on the 2-Wasserstein space, as the regularization parameter ε goes...

Global airport connectivity and resilience: a data-driven approach and inverse-U relationship, 1996–2024

This study analyzes the long-run evolution of global airport connectivity from 1996 to 2024 and examines how resilience to major shocks varies across the connectivity distribution. Using an extended Global Airport Connectivity Index (GACI) panel covering 101,049 airport–year obse...

Detection and Safeguarding of Chinese Toxic Content from Users and LLMs: A Survey

Abstract Toxic content detection and safeguarding have become important topics in natural language processing and affective computing, as they involve the analysis of offensive expressions and harmful attitudes in language. With the widespread adoption of social media, diverse fo...

Effect of chocolate preference and cocoa content on experimentally induced muscle pain

Abstract Objectives Chocolate consumption has been associated with pain reduction, but it remains unclear whether this effect depends on cocoa concentration or individual preference. This study aimed to investigate whether chocolate preference and/or cocoa content modulate experi...

Replication Data for: How Shocks Travel: The Cross-Border Impact of Natural Disasters in Firm Networks

Replication package for "How Shocks Travel: The Cross-Border Impact of Natural Disasters in Firm Networks" (IMF Economic Review). The package contains all programs used to construct the estimation samples and to produce every table and figure in the paper, along with documentatio...

Distortion of Multi-Winner Elections on the Line Metric: The Polar Comparison Rule

We study the problem of minimizing metric distortion in multi-winner elections, where a committee of size k is selected from a set of candidates based on voters’ ordinal preferences. We assume that voters and candidates are embedded on a line metric, and social cost is determined...

Finite-field QED corrections to vacuum birefringence and magnetar polarization transport

Abstract We study low-energy photon propagation in a constant magnetic field within the finite-field one-loop Heisenberg–Euler framework and apply the resulting mode-dependent refractive indices to magnetar polarization transport. In a centered-dipole model, the polarization-limi...

Stereotactic Prostate Cancer Ablative Re‐Irradiation: A Systematic Review and Meta‐Analysis (SPARE)

ABSTRACT Background Stereotactic ablative radiotherapy (SABR) is emerging as an alternative treatment for patients with locally recurrent prostate cancer after previous radiation. This approach allows for precise target coverage while limiting toxicity to surrounding organs. Howe...

Socio-hydrogeology: The past, present, and future of a people-centred and place-based approach to groundwater science

Groundwater systems are shaped by deeply interwoven physical processes and social dynamics, yet traditional hydrogeological approaches have often treated these domains separately. Over the past decade, socio-hydrogeology has emerged in response, offering an approach that systemat...

Occupational HPV Exposure in Otolaryngology: A Scoping Review of Detection, Risk, and Prevention

OBJECTIVES: To characterize the current evidence regarding occupational human papillomavirus (HPV) exposure in otolaryngology, including mechanistic evidence of plume contamination, clinical evidence of infection among healthcare workers, and preventive practices related to perso...

Determinants of scaled implementation for electronic laboratory information systems in 27 clinical laboratories in Côte d’Ivoire: a mixed-methods study applying the Consolidated Framework for Implementation Research (CFIR)

Abstract Background Electronic laboratory information systems (LIS) are critical for promoting data quality and improving laboratory performance, but sustained implementation following system deployment in resource-limited settings can be challenging. The OpenELIS project in Côte...

Profiles of active transportation injury survivors: findings from a British Columbia inception cohort

Active transportation (AT) uptake is increasing as a result of its beneficial effects on health and the environment. Active transport injury (ATI) events that do not involve a motor vehicle are common but go unreported in traffic injury databases. This manuscript reports sociodem...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

Granzymes in Neuroinflammation and Neurodegenerative Diseases

Abstract Neuroinflammation is a central driver of numerous neurological disorders. While granzymes have classically been studied as cytotoxic effector molecules secreted from immune cells along with the pore-forming molecule, perforin, accumulating evidence suggests that these se...

“I know how important it is”: A qualitative analysis of participants’ experiences in a vaccine safety study

Specialist immunization clinics can support vaccination counseling for individuals experiencing adverse events following immunization (AEFIs) and research into AEFIs. We sought to describe the experiences of participants from the Canadian Special Immunization Clinic Network COVID...

The distribution and origin of Mercury’s crustal magnetization

Mercury is the only planet other than Earth to possess both a global magnetic field that arises from a core dynamo, and a crustal magnetic field that arises from magnetized rocks. Crustal fields provide unique records of a planet’s interior state and evolution because magnetizati...

Toward federated large language models in medicine: a parameter-efficient framework for privacy-preserving, multi-institutional adaptation

Large language models (LLMs) are increasingly adapted for medical applications, but most are trained using data from a single institution because privacy and governance constraints prevent multi-institutional data sharing. As a result, these models often generalize poorly across...

Strategic Redirection: AI as Tool and AI as Mineral Kin in Indigenous Futures

This is the second foundational paper of the Meta-Relationality and Artificial Intelligence Research Project at the University of Victoria. This article approaches artificial intelligence from the position of an Indigenous person who engages it strategically. I do not understand...