University of Bologna

Real-world adjunctive use of an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes in drug-resistant epilepsy: the multicentre retrospective ARMILLA study

The purpose of this study was to describe real-world adjunctive use, tolerability, and hypothesis-generating seizure and multidomain outcomes of LALBAAY, an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes (FSMP), in patients with drug-resistant epilepsy (DRE)....

Non-compliance at work: Workarounds and inefficiencies in the ‘smart’ factory

Drawing on 68 semi-structured interviews with assembly-line workers and other informants, this article examines workers’ non-compliant behaviour in an Italian manufacturing company. Our research underscores that workers engage in non-compliance not to defy managerial authority, b...

What Drives the Selectivity of 5-(Hydroxymethyl)furfural Electroreduction over Copper in Mildly Basic Medium?

Abstract 2,5-Bishydroxymethylfuran (BHMF) is an important bio-based monomer that can be produced via the electrochemical reduction of 5-(hydroxymethyl)furfural (HMF) on Cu electrocatalysts. Under mildly alkaline conditions, however, BHMF formation competes with hydrodimerization...

Lantern bearers and beavers: ecosystem engineers foster abundance of fireflies along European rivers

Abstract Insect declines are among the most pressing biodiversity issues of our time, with consequences for ecosystem functioning and human well-being. Fireflies (Coleoptera: Lampyridae) are emblematic insects, whose populations are declining worldwide due to habitat alteration,...

Polar and e-Radical Strain-Release Strategies for Accessing Functionalized 2-Oxabicyclo[2.1.1]hexan-3-ones from Bicyclo[1.1.0]butanes

Abstract 2-Oxabicyclo[2.1.1]hexanes (OBHs) have emerged as valuable saturated aromatic replacements, whereas their lactone analogues, 2-oxabicyclo[2.1.1]hexan-3-ones (OBHOs) remain underexplored, because of limited synthetic access. Herein, we report complementary polar and elect...

Real-world Italian experience with asciminib in chronic myeloid leukaemia–chronic phase: case series and drug profile overview

Abstract Asciminib selectively targets the myristoyl pocket of ABL1, offering high specificity and a potentially improved safety profile. Its efficacy has been demonstrated in both clinical trials and real-world settings, including heavily pretreated patients and those with T315I...

Barycentric Stability of Nonlocal Perimeters: the Convex Case

We establish a sharp form of a nonlocal quantitative isoperimetric inequality involving the barycentric asymmetry for convex sets. This result can be seen as the nonlocal analogue of the one obtained by B. Fuglede [Lower estimate of the isoperimetric deficit of convex domains in...

Variational inequalities and smooth-fit principle for singular stochastic control problems in Hilbert spaces

We consider a class of infinite-dimensional singular stochastic control problems. These can be thought of as spatial monotone follower problems and find applications in spatial models of production and climate transition. Let (D,M,μ) be a finite measure space and consider the Hil...

Bittersweet dynamics from flowers to fruits: chemometric molecular networking reveals metabolic changes towards reduced toxicity over ontogeny in above-ground Solanum dulcamara chemotypes

Poisonous plants frequently deploy toxic metabolites in an organ- and ontogenetic-specific manner, yet the developmental dynamics of these plant specialised metabolites remain poorly understood. In the Solanaceae, steroidal glycosides (SGs), including steroidal glycoalkaloids (SG...

Off-label prescribing in pediatrics: between regulatory gaps and clinical evidence

Despite important regulatory progress, evidence supporting the use of medicines in children remains limited, and off-label prescribing continues to be common in pediatric practice. Regulatory initiatives such as the United States Pediatric Research Equity Act (PREA) and the Europ...

What are the knowledge, use, and perceived benefits and limitations of artificial intelligence chatbots among Italian nursing students? A cross-sectional multicentre study

Exploring students’ knowledge, use, and perceptions of Artificial Intelligence (AI) chatbots may inform strategies in the educational context. However, limited evidence is available on Italian nursing students, leaving this field largely unexplored. A cross-sectional online surve...

Epidemiology, impact on oncologic treatments, and management of community-acquired respiratory virus (CARV) infections in pediatric onco-hematology patients: a survey among Italian pediatric oncology hematology centres (AIEOP)

Abstract A survey was conducted across Italian Pediatric Onco‑Hematology centres to assess epidemiology of community‑acquired respiratory virus (CARV) infections, chemotherapy management, Oseltamivir use and vaccination policies. Most reported infections were mild and managed out...

Bioinspired CNNs for border completion in occluded images

Abstract We exploit the mathematical modeling of the border completion problem in the visual cortex to design convolutional neural network (CNN) filters that enhance robustness to image occlusions. We evaluate our CNN architecture, BorderNet, on three occluded datasets–MNIST, Fas...

Laying the Groundwork for Moveable Heritage Disaster Risk Management: A Database-Driven Evacuation Tool at the Musée d’Archéologie Nationale

This paper presents a case study conducted at the Musée d’Archéologie Nationale (National Archaeology Museum) in France, to develop a dedicated database application to safeguard its moveable heritage from risks, as a foundational component of the museum’s wider Disaster Risk Mana...

Skills and far-right support: how education and training systems moderate voting behaviour in the knowledge economy

Technological change has reshaped labour-market risks for non-tertiary educated workers, but these risks vary across educational tracks and institutional contexts. This article connects comparative political economy research on skill formation with scholarship on far-right voting...

Deterrence or prevention? The challenges of algorithmic crime prediction in urban spaces

Predictive policing emerged as a promise to prevent crime before it occurs. Despite the waning hype, predictive policing remains an active practice, especially in urban contexts. Drawing on ethnographic research on a predictive policing system of a German state police force, this...

How does adding PD-(L)1 inhibitors to platinum-etoposide treatment of small cell lung cancer improve survival outcomes?

1. The introduction of immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis has improved survival outcomes in patients with both extensive stage (ES, 60-70% of cases) and limited stage...

How conformational dynamics shape hydrogen–deuterium exchange isotopic envelopes

Hydrogen-deuterium exchange mass spectrometry (HDX-MS) measures peptide-level mass distributions, whereas exchange is controlled microscopically by fluctuations in the exposure of individual backbone amides. In this work, exchange is represented in terms of integrated conformatio...

Autologous Collagen-Induced Chondrogenesis (ACIC) for Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis

Background and Objectives: Autologous Collagen-Induced Chondrogenesis (ACIC) is a regenerative technique for treating osteochondral lesions that combines microfracture with the application of an injectable atelocollagen scaffold over the defect. This scaffold stabilizes the marro...

Construction and characterisation of the DarkSide-20k veto silicon photo-multiplier tiles

Abstract Silicon photo-multipliers (SiPMs) are state-of-the-art sensors capable of detecting a single photoelectron under cryogenic conditions, with potentially lower radioactivity than widely used photomultiplier tubes. The DarkSide-20k experiment, designed to perform direct dar...