University of Bologna

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

NIR‐Light‐Activable Macrophage Polarization Orchestration Using Laser‐Structured Janus Nanoplatform Derived from Waste for Infected Wound Healing

ABSTRACT The human skin is highly susceptible to bacterial infections and inflammation when its integrity is disrupted. Treatment of infected wounds is a big challenge in modern medicine, and rising antibiotic resistance motivates the development of antibiotic‐free therapies. Her...

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcom...

Neanderthal’s heel: How the Neanderthal’s external calcaneal shape uniquely differs from that of modern humans

Neanderthals exhibit unique morphological adaptations in their calcaneus compared to Homo sapiens , shedding light on distinct evolutionary pressures and functional requirements shaping their respective foot anatomy. This study assesses which calcaneal traits represent plesiomorp...

Ecological Quality Assessment of Mediterranean Wadis in the Bizerte Lagoon Catchment (Northern Tunisia) Using Benthic Diatoms

The study presents an integrated assessment of water quality in wadis of the Bizerte Lagoon catchment (Northern Tunisia), using benthic diatom assemblages. Seasonal sampling was conducted between winter 2023 and winter 2024 in three wadis exposed to varying anthropogenic pressure...

Comparative cytoarchitectural and proteomic analysis of the primary motor cortex in pigs and wild boars reveals domestication associated changes

Background Domestication appears to modify the morphology and physiology of the central nervous system. Owing to the limited availability of proteomic and cytoarchitectural data for comparisons between wild and domesticated species, we conducted a comparative analysis of the cyto...

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

Evidence to guide the treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with...

Streamlining Habitats Directive Reporting with Open Biodiversity Data: Evidence for the Nature Directives Stress Test [Policy Brief]

Biodiversity monitoring under Article 17 of the EU Habitats Directive (Council Directive 92/43/EEC) remains inconsistent across European Member States. Although all Member States follow the same reporting framework, national assessments are based on national monitoring programmes...

Systemic explainability for autonomous driving: connecting ethics to law and society

Abstract Self-driving vehicles challenge legal, socio-technical, and ethical frameworks due to their opacity, unpredictability, and autonomous decision-making, raising concerns for safety, trustworthiness, and responsibility attribution. In response, explainable artificial intell...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

When Types Intersect and Effects Get Handled

We introduce a novel intersection type system for a λ-calculus with algebraic effects and handlers. The system, inherently behavioral in nature, enjoys the classical properties of intersection type systems, in particular subject reduction and expansion. It thus characterizes the...

Kombucha Bacterial Cellulose Obtained from Tea Fermentation for Biomedical Applications

Abstract The symbiotic culture of bacteria and yeast (SCOBY) driving kombucha tea fermentation produces a cellulose pellicle with remarkable promise for biomedical applications. Unlike well-studied bacterial cellulose (BC), which is produced by single-strain cultures, the underex...

Chronological Age and Adaptive Outcomes Following Neuropsychomotor and Aquatic Interventions in Children with Autism: A Secondary Analysis

Background: Autism Spectrum Disorder (ASD) can be conceptualized not as a static condition but as a dynamic disorder of developmental regulation, in which neuroplastic potential is translated into functional gains only through structured, experience-dependent therapeutic input. N...

Widespread thermophilization but weak link to climate warming in Europe’s summit plant communities

Abstract Recent changes in alpine vegetation are often attributed to climate warming, particularly community composition shifts towards more warmth-associated species, or thermophilization. Here we assess the link between thermophilization and warming across 53 European mountain...

The Consequences of Promoting Data Literacy among Graduate Students

Abstract We study the impact of a data literacy program on graduate students’ skills and academic outcomes at a large Italian university. The program targets students expected to have weak quantitative skills and provides 120 h of training in data interpretation and processing al...

Targeted neuromodulation of perceptual decision-making networks causally dissociates sensory and metacognitive performance

ABSTRACT Perceptual judgements and their subjective evaluation (i.e., metacognition) are considered tightly coupled aspects of decision-making. Yet, emerging evidence suggests that distinct neural mechanisms underlie these processes. In motion perception, studies have identified...

3A Cyanide‐Bridged Ru–Fe Supramolecular Photocatalyst for Efficient CO 2 Reduction

Supramolecular control over electron transfer is a key challenge in artificial photosynthesis. Here, we report a cyano‐bridged Ru–Fe supramolecular photocatalyst that self‐assembles in solution through spontaneous coordination. This preorganized architecture enables ultrafast exc...

Dimension comparison for Student's statistic under symmetric unimodality

Preprint. This manuscript has not undergone journal peer review.

Comparative Efficacy Of Different Computer-Aided Detection Products in Colonoscopy: A Network Meta-Analysis Of Randomized Controlled Trials.

Background and aims: Multiple computer-aided detection (CADe) systems have been developed to improve adenoma detection during colonoscopy, but their comparative efficacy and consistency of effect remain uncertain. This network meta-analysis aimed to compare the efficacy of differ...

Building sets, Chow rings, and their Hilbert series

Abstract We establish formulas for the Hilbert series of the Chow ring of a polymatroid using arbitrary building sets. For braid matroids and minimal building sets, our results produce new formulas for the Poincaré polynomial of the moduli space $$\overline{\mathcal {M}}_{0,n+1}$...